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Results: 1 to 20 of 75

1.

A fundamental trade off in covalent switching and its circumvention by enzyme bifunctionality in glucose homeostasis.

Dasgupta T, Croll DH, Owen JA, Vander Heiden MG, Locasale JW, Alon U, Cantley LC, Gunawardena J.

J Biol Chem. 2014 Mar 14. [Epub ahead of print]

PMID:
24634222
[PubMed - as supplied by publisher]
Free Article
2.

PKM2 isoform-specific deletion reveals a differential requirement for pyruvate kinase in tumor cells.

Israelsen WJ, Dayton TL, Davidson SM, Fiske BP, Hosios AM, Bellinger G, Li J, Yu Y, Sasaki M, Horner JW, Burga LN, Xie J, Jurczak MJ, DePinho RA, Clish CB, Jacks T, Kibbey RG, Wulf GM, Di Vizio D, Mills GB, Cantley LC, Vander Heiden MG.

Cell. 2013 Oct 10;155(2):397-409. doi: 10.1016/j.cell.2013.09.025.

PMID:
24120138
[PubMed - indexed for MEDLINE]
3.

Metabolic targets for cancer therapy.

Galluzzi L, Kepp O, Vander Heiden MG, Kroemer G.

Nat Rev Drug Discov. 2013 Nov;12(11):829-46. doi: 10.1038/nrd4145. Epub 2013 Oct 11. Erratum in: Nat Rev Drug Discov. 2013 Dec;12(12):963.

PMID:
24113830
[PubMed - indexed for MEDLINE]
4.

Global transcriptional and translational repression in human-embryonic-stem-cell-derived Rett syndrome neurons.

Li Y, Wang H, Muffat J, Cheng AW, Orlando DA, Lovén J, Kwok SM, Feldman DA, Bateup HS, Gao Q, Hockemeyer D, Mitalipova M, Lewis CA, Vander Heiden MG, Sur M, Young RA, Jaenisch R.

Cell Stem Cell. 2013 Oct 3;13(4):446-58. doi: 10.1016/j.stem.2013.09.001.

PMID:
24094325
[PubMed - in process]
5.

Exploiting tumor metabolism: challenges for clinical translation.

Vander Heiden MG.

J Clin Invest. 2013 Sep 3;123(9):3648-51. doi: 10.1172/JCI72391. Epub 2013 Sep 3.

PMID:
23999437
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

ML265: A potent PKM2 activator induces tetramerization and reduces tumor formation and size in a mouse xenograft model.

Walsh MJ, Brimacombe KR, Anastasiou D, Yu Y, Israelsen WJ, Hong BS, Tempel W, Dimov S, Veith H, Yang H, Kung C, Yen KE, Dang L, Salituro F, Auld DS, Park HW, Vander Heiden MG, Thomas CJ, Shen M, Boxer MB.

Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
2012 Mar 16 [updated 2013 May 8].

PMID:
23905203
[PubMed]
Books & Documents
7.

Reductive glutamine metabolism is a function of the α-ketoglutarate to citrate ratio in cells.

Fendt SM, Bell EL, Keibler MA, Olenchock BA, Mayers JR, Wasylenko TM, Vokes NI, Guarente L, Vander Heiden MG, Stephanopoulos G.

Nat Commun. 2013;4:2236. doi: 10.1038/ncomms3236.

PMID:
23900562
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

ML285 affects reactive oxygen species’ inhibition of pyruvate kinase M2.

Brimacombe KR, Anastasiou D, Hong BS, Tempel W, Dimov S, Veith H, Auld DS, Vander Heiden MG, Thomas CJ, Park HW, Shen M, Cantley LC, Boxer MB.

Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
2012 Aug 3 [updated 2013 May 8].

PMID:
23885364
[PubMed]
Books & Documents
9.

BCAT1 defines gliomas by IDH status.

Mayers JR, Vander Heiden MG.

Nat Med. 2013 Jul;19(7):816-7. doi: 10.1038/nm.3263. No abstract available.

PMID:
23836221
[PubMed - indexed for MEDLINE]
10.

Pyruvate as a pivot point for oncogene-induced senescence.

Olenchock BA, Vander Heiden MG.

Cell. 2013 Jun 20;153(7):1429-30. doi: 10.1016/j.cell.2013.06.001.

PMID:
23791173
[PubMed - indexed for MEDLINE]
11.

Metformin decreases glucose oxidation and increases the dependency of prostate cancer cells on reductive glutamine metabolism.

Fendt SM, Bell EL, Keibler MA, Davidson SM, Wirth GJ, Fiske B, Mayers JR, Schwab M, Bellinger G, Csibi A, Patnaik A, Blouin MJ, Cantley LC, Guarente L, Blenis J, Pollak MN, Olumi AF, Vander Heiden MG, Stephanopoulos G.

Cancer Res. 2013 Jul 15;73(14):4429-38. doi: 10.1158/0008-5472.CAN-13-0080. Epub 2013 May 17.

PMID:
23687346
[PubMed - indexed for MEDLINE]
12.

Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells.

Commisso C, Davidson SM, Soydaner-Azeloglu RG, Parker SJ, Kamphorst JJ, Hackett S, Grabocka E, Nofal M, Drebin JA, Thompson CB, Rabinowitz JD, Metallo CM, Vander Heiden MG, Bar-Sagi D.

Nature. 2013 May 30;497(7451):633-7. doi: 10.1038/nature12138. Epub 2013 May 12.

PMID:
23665962
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Heterogeneity of tumor-induced gene expression changes in the human metabolic network.

Hu J, Locasale JW, Bielas JH, O'Sullivan J, Sheahan K, Cantley LC, Vander Heiden MG, Vitkup D.

Nat Biotechnol. 2013 Jun;31(6):522-9. doi: 10.1038/nbt.2530. Epub 2013 Apr 21.

PMID:
23604282
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Allosteric regulation of PKM2 allows cellular adaptation to different physiological states.

Gui DY, Lewis CA, Vander Heiden MG.

Sci Signal. 2013 Feb 19;6(263):pe7. doi: 10.1126/scisignal.2003925.

PMID:
23423437
[PubMed - indexed for MEDLINE]
15.

Development of a colon cancer GEMM-derived orthotopic transplant model for drug discovery and validation.

Martin ES, Belmont PJ, Sinnamon MJ, Richard LG, Yuan J, Coffee EM, Roper J, Lee L, Heidari P, Lunt SY, Goel G, Ji X, Xie Z, Xie T, Lamb J, Weinrich SL, VanArsdale T, Bronson RT, Xavier RJ, Vander Heiden MG, Kan JL, Mahmood U, Hung KE.

Clin Cancer Res. 2013 Jun 1;19(11):2929-40. doi: 10.1158/1078-0432.CCR-12-2307. Epub 2013 Feb 12.

PMID:
23403635
[PubMed - indexed for MEDLINE]
16.

Understanding metabolic regulation and its influence on cell physiology.

Metallo CM, Vander Heiden MG.

Mol Cell. 2013 Feb 7;49(3):388-98. doi: 10.1016/j.molcel.2013.01.018. Review.

PMID:
23395269
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Glucose metabolism impacts the spatiotemporal onset and magnitude of HSC induction in vivo.

Harris JM, Esain V, Frechette GM, Harris LJ, Cox AG, Cortes M, Garnaas MK, Carroll KJ, Cutting CC, Khan T, Elks PM, Renshaw SA, Dickinson BC, Chang CJ, Murphy MP, Paw BH, Vander Heiden MG, Goessling W, North TE.

Blood. 2013 Mar 28;121(13):2483-93. doi: 10.1182/blood-2012-12-471201. Epub 2013 Jan 22.

PMID:
23341543
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Small molecule activation of PKM2 in cancer cells induces serine auxotrophy.

Kung C, Hixon J, Choe S, Marks K, Gross S, Murphy E, DeLaBarre B, Cianchetta G, Sethumadhavan S, Wang X, Yan S, Gao Y, Fang C, Wei W, Jiang F, Wang S, Qian K, Saunders J, Driggers E, Woo HK, Kunii K, Murray S, Yang H, Yen K, Liu W, Cantley LC, Vander Heiden MG, Su SM, Jin S, Salituro FG, Dang L.

Chem Biol. 2012 Sep 21;19(9):1187-98. doi: 10.1016/j.chembiol.2012.07.021.

PMID:
22999886
[PubMed - in process]
Free PMC Article
19.

Cancer. Glycosylation to adapt to stress.

Mattaini KR, Vander Heiden MG.

Science. 2012 Aug 24;337(6097):925-6. doi: 10.1126/science.1227513. No abstract available.

PMID:
22923571
[PubMed - indexed for MEDLINE]
20.

Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis.

Anastasiou D, Yu Y, Israelsen WJ, Jiang JK, Boxer MB, Hong BS, Tempel W, Dimov S, Shen M, Jha A, Yang H, Mattaini KR, Metallo CM, Fiske BP, Courtney KD, Malstrom S, Khan TM, Kung C, Skoumbourdis AP, Veith H, Southall N, Walsh MJ, Brimacombe KR, Leister W, Lunt SY, Johnson ZR, Yen KE, Kunii K, Davidson SM, Christofk HR, Austin CP, Inglese J, Harris MH, Asara JM, Stephanopoulos G, Salituro FG, Jin S, Dang L, Auld DS, Park HW, Cantley LC, Thomas CJ, Vander Heiden MG.

Nat Chem Biol. 2012 Oct;8(10):839-47. Erratum in: Nat Chem Biol. 2012 Dec;8(12):1008.

PMID:
22922757
[PubMed - indexed for MEDLINE]
Free PMC Article

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