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Results: 1 to 20 of 90

1.

An epitope tag alters phosphoglycerate dehydrogenase structure and impairs ability to support cell proliferation.

Mattaini KR, Brignole EJ, Kini M, Davidson SM, Fiske BP, Drennan CL, Vander Heiden MG.

Cancer Metab. 2015 Apr 29;3:5. doi: 10.1186/s40170-015-0131-7. eCollection 2015.

2.

Antibody-Mediated Neutralization of Perfringolysin O for Intracellular Protein Delivery.

Yang NJ, Liu DV, Sklaviadis D, Gui DY, Vander Heiden MG, Wittrup KD.

Mol Pharm. 2015 May 4. [Epub ahead of print]

PMID:
25881713
3.

SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance.

Kim D, Fiske BP, Birsoy K, Freinkman E, Kami K, Possemato RL, Chudnovsky Y, Pacold ME, Chen WW, Cantor JR, Shelton LM, Gui DY, Kwon M, Ramkissoon SH, Ligon KL, Kang SW, Snuderl M, Vander Heiden MG, Sabatini DM.

Nature. 2015 Apr 16;520(7547):363-7. doi: 10.1038/nature14363. Epub 2015 Apr 8.

PMID:
25855294
4.

A roadmap for interpreting 13C metabolite labeling patterns from cells.

Buescher JM, Antoniewicz MR, Boros LG, Burgess SC, Brunengraber H, Clish CB, DeBerardinis RJ, Feron O, Frezza C, Ghesquiere B, Gottlieb E, Hiller K, Jones RG, Kamphorst JJ, Kibbey RG, Kimmelman AC, Locasale JW, Lunt SY, Maddocks OD, Malloy C, Metallo CM, Meuillet EJ, Munger J, Nöh K, Rabinowitz JD, Ralser M, Sauer U, Stephanopoulos G, St-Pierre J, Tennant DA, Wittmann C, Vander Heiden MG, Vazquez A, Vousden K, Young JD, Zamboni N, Fendt SM.

Curr Opin Biotechnol. 2015 Feb 28;34:189-201. doi: 10.1016/j.copbio.2015.02.003. [Epub ahead of print] Review.

PMID:
25731751
5.

Human pancreatic cancer tumors are nutrient poor and tumor cells actively scavenge extracellular protein.

Kamphorst JJ, Nofal M, Commisso C, Hackett SR, Lu W, Grabocka E, Vander Heiden MG, Miller G, Drebin JA, Bar-Sagi D, Thompson CB, Rabinowitz JD.

Cancer Res. 2015 Feb 1;75(3):544-53. doi: 10.1158/0008-5472.CAN-14-2211.

PMID:
25644265
6.

Famine versus feast: understanding the metabolism of tumors in vivo.

Mayers JR, Vander Heiden MG.

Trends Biochem Sci. 2015 Mar;40(3):130-40. doi: 10.1016/j.tibs.2015.01.004. Epub 2015 Jan 29. Review.

PMID:
25639751
7.

Acetate metabolism in cancer cells.

Hosios AM, Vander Heiden MG.

Cancer Metab. 2014 Dec 11;2(1):27. doi: 10.1186/s40170-014-0027-y. eCollection 2014. No abstract available.

8.

Pyruvate kinase isoform expression alters nucleotide synthesis to impact cell proliferation.

Lunt SY, Muralidhar V, Hosios AM, Israelsen WJ, Gui DY, Newhouse L, Ogrodzinski M, Hecht V, Xu K, Acevedo PN, Hollern DP, Bellinger G, Dayton TL, Christen S, Elia I, Dinh AT, Stephanopoulos G, Manalis SR, Yaffe MB, Andrechek ER, Fendt SM, Vander Heiden MG.

Mol Cell. 2015 Jan 8;57(1):95-107. doi: 10.1016/j.molcel.2014.10.027. Epub 2014 Dec 4.

PMID:
25482511
9.

Human phosphoglycerate dehydrogenase produces the oncometabolite D-2-hydroxyglutarate.

Fan J, Teng X, Liu L, Mattaini KR, Looper RE, Vander Heiden MG, Rabinowitz JD.

ACS Chem Biol. 2015 Feb 20;10(2):510-6. doi: 10.1021/cb500683c. Epub 2014 Nov 18.

PMID:
25406093
10.

Elevation of circulating branched-chain amino acids is an early event in human pancreatic adenocarcinoma development.

Mayers JR, Wu C, Clish CB, Kraft P, Torrence ME, Fiske BP, Yuan C, Bao Y, Townsend MK, Tworoger SS, Davidson SM, Papagiannakopoulos T, Yang A, Dayton TL, Ogino S, Stampfer MJ, Giovannucci EL, Qian ZR, Rubinson DA, Ma J, Sesso HD, Gaziano JM, Cochrane BB, Liu S, Wactawski-Wende J, Manson JE, Pollak MN, Kimmelman AC, Souza A, Pierce K, Wang TJ, Gerszten RE, Fuchs CS, Vander Heiden MG, Wolpin BM.

Nat Med. 2014 Oct;20(10):1193-8. doi: 10.1038/nm.3686. Epub 2014 Sep 28.

11.

Cell-state-specific metabolic dependency in hematopoiesis and leukemogenesis.

Wang YH, Israelsen WJ, Lee D, Yu VW, Jeanson NT, Clish CB, Cantley LC, Vander Heiden MG, Scadden DT.

Cell. 2014 Sep 11;158(6):1309-23. doi: 10.1016/j.cell.2014.07.048.

PMID:
25215489
12.

Tracing compartmentalized NADPH metabolism in the cytosol and mitochondria of mammalian cells.

Lewis CA, Parker SJ, Fiske BP, McCloskey D, Gui DY, Green CR, Vokes NI, Feist AM, Vander Heiden MG, Metallo CM.

Mol Cell. 2014 Jul 17;55(2):253-63. doi: 10.1016/j.molcel.2014.05.008. Epub 2014 May 29.

PMID:
24882210
13.

IDH1 mutations alter citric acid cycle metabolism and increase dependence on oxidative mitochondrial metabolism.

Grassian AR, Parker SJ, Davidson SM, Divakaruni AS, Green CR, Zhang X, Slocum KL, Pu M, Lin F, Vickers C, Joud-Caldwell C, Chung F, Yin H, Handly ED, Straub C, Growney JD, Vander Heiden MG, Murphy AN, Pagliarini R, Metallo CM.

Cancer Res. 2014 Jun 15;74(12):3317-31. doi: 10.1158/0008-5472.CAN-14-0772-T. Epub 2014 Apr 22.

PMID:
24755473
14.

Targetable signaling pathway mutations are associated with malignant phenotype in IDH-mutant gliomas.

Wakimoto H, Tanaka S, Curry WT, Loebel F, Zhao D, Tateishi K, Chen J, Klofas LK, Lelic N, Kim JC, Dias-Santagata D, Ellisen LW, Borger DR, Fendt SM, Vander Heiden MG, Batchelor TT, Iafrate AJ, Cahill DP, Chi AS.

Clin Cancer Res. 2014 Jun 1;20(11):2898-909. doi: 10.1158/1078-0432.CCR-13-3052. Epub 2014 Apr 8.

15.

A DERL3-associated defect in the degradation of SLC2A1 mediates the Warburg effect.

Lopez-Serra P, Marcilla M, Villanueva A, Ramos-Fernandez A, Palau A, Leal L, Wahi JE, Setien-Baranda F, Szczesna K, Moutinho C, Martinez-Cardus A, Heyn H, Sandoval J, Puertas S, Vidal A, Sanjuan X, Martinez-Balibrea E, Viñals F, Perales JC, Bramsem JB, Ørntoft TF, Andersen CL, Tabernero J, McDermott U, Boxer MB, Vander Heiden MG, Albar JP, Esteller M.

Nat Commun. 2014 Apr 3;5:3608. doi: 10.1038/ncomms4608.

16.

A fundamental trade-off in covalent switching and its circumvention by enzyme bifunctionality in glucose homeostasis.

Dasgupta T, Croll DH, Owen JA, Vander Heiden MG, Locasale JW, Alon U, Cantley LC, Gunawardena J.

J Biol Chem. 2014 May 9;289(19):13010-25. doi: 10.1074/jbc.M113.546515. Epub 2014 Mar 14.

17.

PKM2 isoform-specific deletion reveals a differential requirement for pyruvate kinase in tumor cells.

Israelsen WJ, Dayton TL, Davidson SM, Fiske BP, Hosios AM, Bellinger G, Li J, Yu Y, Sasaki M, Horner JW, Burga LN, Xie J, Jurczak MJ, DePinho RA, Clish CB, Jacks T, Kibbey RG, Wulf GM, Di Vizio D, Mills GB, Cantley LC, Vander Heiden MG.

Cell. 2013 Oct 10;155(2):397-409. doi: 10.1016/j.cell.2013.09.025.

18.

Metabolic targets for cancer therapy.

Galluzzi L, Kepp O, Vander Heiden MG, Kroemer G.

Nat Rev Drug Discov. 2013 Nov;12(11):829-46. doi: 10.1038/nrd4145. Epub 2013 Oct 11. Erratum in: Nat Rev Drug Discov. 2013 Dec;12(12):963.

PMID:
24113830
19.

Global transcriptional and translational repression in human-embryonic-stem-cell-derived Rett syndrome neurons.

Li Y, Wang H, Muffat J, Cheng AW, Orlando DA, Lovén J, Kwok SM, Feldman DA, Bateup HS, Gao Q, Hockemeyer D, Mitalipova M, Lewis CA, Vander Heiden MG, Sur M, Young RA, Jaenisch R.

Cell Stem Cell. 2013 Oct 3;13(4):446-58. doi: 10.1016/j.stem.2013.09.001.

20.

Exploiting tumor metabolism: challenges for clinical translation.

Vander Heiden MG.

J Clin Invest. 2013 Sep;123(9):3648-51. doi: 10.1172/JCI72391. Epub 2013 Sep 3.

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