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Results: 1 to 20 of 81

1.

Elevation of circulating branched-chain amino acids is an early event in human pancreatic adenocarcinoma development.

Mayers JR, Wu C, Clish CB, Kraft P, Torrence ME, Fiske BP, Yuan C, Bao Y, Townsend MK, Tworoger SS, Davidson SM, Papagiannakopoulos T, Yang A, Dayton TL, Ogino S, Stampfer MJ, Giovannucci EL, Qian ZR, Rubinson DA, Ma J, Sesso HD, Gaziano JM, Cochrane BB, Liu S, Wactawski-Wende J, Manson JE, Pollak MN, Kimmelman AC, Souza A, Pierce K, Wang TJ, Gerszten RE, Fuchs CS, Vander Heiden MG, Wolpin BM.

Nat Med. 2014 Oct;20(10):1193-8. doi: 10.1038/nm.3686. Epub 2014 Sep 28.

PMID:
25261994
[PubMed - in process]
2.

Cell-state-specific metabolic dependency in hematopoiesis and leukemogenesis.

Wang YH, Israelsen WJ, Lee D, Yu VW, Jeanson NT, Clish CB, Cantley LC, Vander Heiden MG, Scadden DT.

Cell. 2014 Sep 11;158(6):1309-23. doi: 10.1016/j.cell.2014.07.048.

PMID:
25215489
[PubMed - in process]
3.

Tracing compartmentalized NADPH metabolism in the cytosol and mitochondria of mammalian cells.

Lewis CA, Parker SJ, Fiske BP, McCloskey D, Gui DY, Green CR, Vokes NI, Feist AM, Vander Heiden MG, Metallo CM.

Mol Cell. 2014 Jul 17;55(2):253-63. doi: 10.1016/j.molcel.2014.05.008. Epub 2014 May 29.

PMID:
24882210
[PubMed - indexed for MEDLINE]
4.

IDH1 mutations alter citric acid cycle metabolism and increase dependence on oxidative mitochondrial metabolism.

Grassian AR, Parker SJ, Davidson SM, Divakaruni AS, Green CR, Zhang X, Slocum KL, Pu M, Lin F, Vickers C, Joud-Caldwell C, Chung F, Yin H, Handly ED, Straub C, Growney JD, Vander Heiden MG, Murphy AN, Pagliarini R, Metallo CM.

Cancer Res. 2014 Jun 15;74(12):3317-31. doi: 10.1158/0008-5472.CAN-14-0772-T. Epub 2014 Apr 22.

PMID:
24755473
[PubMed - indexed for MEDLINE]
5.

Targetable signaling pathway mutations are associated with malignant phenotype in IDH-mutant gliomas.

Wakimoto H, Tanaka S, Curry WT, Loebel F, Zhao D, Tateishi K, Chen J, Klofas LK, Lelic N, Kim JC, Dias-Santagata D, Ellisen LW, Borger DR, Fendt SM, Vander Heiden MG, Batchelor TT, Iafrate AJ, Cahill DP, Chi AS.

Clin Cancer Res. 2014 Jun 1;20(11):2898-909. doi: 10.1158/1078-0432.CCR-13-3052. Epub 2014 Apr 8.

PMID:
24714777
[PubMed - in process]
6.

A DERL3-associated defect in the degradation of SLC2A1 mediates the Warburg effect.

Lopez-Serra P, Marcilla M, Villanueva A, Ramos-Fernandez A, Palau A, Leal L, Wahi JE, Setien-Baranda F, Szczesna K, Moutinho C, Martinez-Cardus A, Heyn H, Sandoval J, Puertas S, Vidal A, Sanjuan X, Martinez-Balibrea E, Viñals F, Perales JC, Bramsem JB, Ørntoft TF, Andersen CL, Tabernero J, McDermott U, Boxer MB, Vander Heiden MG, Albar JP, Esteller M.

Nat Commun. 2014 Apr 3;5:3608. doi: 10.1038/ncomms4608.

PMID:
24699711
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

A fundamental trade-off in covalent switching and its circumvention by enzyme bifunctionality in glucose homeostasis.

Dasgupta T, Croll DH, Owen JA, Vander Heiden MG, Locasale JW, Alon U, Cantley LC, Gunawardena J.

J Biol Chem. 2014 May 9;289(19):13010-25. doi: 10.1074/jbc.M113.546515. Epub 2014 Mar 14.

PMID:
24634222
[PubMed - indexed for MEDLINE]
8.

PKM2 isoform-specific deletion reveals a differential requirement for pyruvate kinase in tumor cells.

Israelsen WJ, Dayton TL, Davidson SM, Fiske BP, Hosios AM, Bellinger G, Li J, Yu Y, Sasaki M, Horner JW, Burga LN, Xie J, Jurczak MJ, DePinho RA, Clish CB, Jacks T, Kibbey RG, Wulf GM, Di Vizio D, Mills GB, Cantley LC, Vander Heiden MG.

Cell. 2013 Oct 10;155(2):397-409. doi: 10.1016/j.cell.2013.09.025.

PMID:
24120138
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Metabolic targets for cancer therapy.

Galluzzi L, Kepp O, Vander Heiden MG, Kroemer G.

Nat Rev Drug Discov. 2013 Nov;12(11):829-46. doi: 10.1038/nrd4145. Epub 2013 Oct 11. Erratum in: Nat Rev Drug Discov. 2013 Dec;12(12):963.

PMID:
24113830
[PubMed - indexed for MEDLINE]
10.

Global transcriptional and translational repression in human-embryonic-stem-cell-derived Rett syndrome neurons.

Li Y, Wang H, Muffat J, Cheng AW, Orlando DA, Lovén J, Kwok SM, Feldman DA, Bateup HS, Gao Q, Hockemeyer D, Mitalipova M, Lewis CA, Vander Heiden MG, Sur M, Young RA, Jaenisch R.

Cell Stem Cell. 2013 Oct 3;13(4):446-58. doi: 10.1016/j.stem.2013.09.001.

PMID:
24094325
[PubMed - in process]
Free PMC Article
11.

Exploiting tumor metabolism: challenges for clinical translation.

Vander Heiden MG.

J Clin Invest. 2013 Sep 3;123(9):3648-51. doi: 10.1172/JCI72391. Epub 2013 Sep 3.

PMID:
23999437
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

ML265: A potent PKM2 activator induces tetramerization and reduces tumor formation and size in a mouse xenograft model.

Walsh MJ, Brimacombe KR, Anastasiou D, Yu Y, Israelsen WJ, Hong BS, Tempel W, Dimov S, Veith H, Yang H, Kung C, Yen KE, Dang L, Salituro F, Auld DS, Park HW, Vander Heiden MG, Thomas CJ, Shen M, Boxer MB.

Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
2012 Mar 16 [updated 2013 May 8].

PMID:
23905203
[PubMed]
Books & Documents
13.

Reductive glutamine metabolism is a function of the α-ketoglutarate to citrate ratio in cells.

Fendt SM, Bell EL, Keibler MA, Olenchock BA, Mayers JR, Wasylenko TM, Vokes NI, Guarente L, Vander Heiden MG, Stephanopoulos G.

Nat Commun. 2013;4:2236. doi: 10.1038/ncomms3236.

PMID:
23900562
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

ML285 affects reactive oxygen species’ inhibition of pyruvate kinase M2.

Brimacombe KR, Anastasiou D, Hong BS, Tempel W, Dimov S, Veith H, Auld DS, Vander Heiden MG, Thomas CJ, Park HW, Shen M, Cantley LC, Boxer MB.

Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
2012 Aug 3 [updated 2013 May 8].

PMID:
23885364
[PubMed]
Books & Documents
15.

BCAT1 defines gliomas by IDH status.

Mayers JR, Vander Heiden MG.

Nat Med. 2013 Jul;19(7):816-7. doi: 10.1038/nm.3263. No abstract available.

PMID:
23836221
[PubMed - indexed for MEDLINE]
16.

Pyruvate as a pivot point for oncogene-induced senescence.

Olenchock BA, Vander Heiden MG.

Cell. 2013 Jun 20;153(7):1429-30. doi: 10.1016/j.cell.2013.06.001.

PMID:
23791173
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Metformin decreases glucose oxidation and increases the dependency of prostate cancer cells on reductive glutamine metabolism.

Fendt SM, Bell EL, Keibler MA, Davidson SM, Wirth GJ, Fiske B, Mayers JR, Schwab M, Bellinger G, Csibi A, Patnaik A, Blouin MJ, Cantley LC, Guarente L, Blenis J, Pollak MN, Olumi AF, Vander Heiden MG, Stephanopoulos G.

Cancer Res. 2013 Jul 15;73(14):4429-38. doi: 10.1158/0008-5472.CAN-13-0080. Epub 2013 May 17.

PMID:
23687346
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells.

Commisso C, Davidson SM, Soydaner-Azeloglu RG, Parker SJ, Kamphorst JJ, Hackett S, Grabocka E, Nofal M, Drebin JA, Thompson CB, Rabinowitz JD, Metallo CM, Vander Heiden MG, Bar-Sagi D.

Nature. 2013 May 30;497(7451):633-7. doi: 10.1038/nature12138. Epub 2013 May 12.

PMID:
23665962
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Heterogeneity of tumor-induced gene expression changes in the human metabolic network.

Hu J, Locasale JW, Bielas JH, O'Sullivan J, Sheahan K, Cantley LC, Vander Heiden MG, Vitkup D.

Nat Biotechnol. 2013 Jun;31(6):522-9. doi: 10.1038/nbt.2530. Epub 2013 Apr 21.

PMID:
23604282
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Allosteric regulation of PKM2 allows cellular adaptation to different physiological states.

Gui DY, Lewis CA, Vander Heiden MG.

Sci Signal. 2013 Feb 19;6(263):pe7. doi: 10.1126/scisignal.2003925.

PMID:
23423437
[PubMed - indexed for MEDLINE]

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