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Results: 1 to 20 of 209


The combination of thioxodihydroquinazolinones and platinum drugs reverses platinum resistance in tumor cells by inducing mitochondrial apoptosis independent of Bax and Bak.

Qian W, Salamoun J, Wang J, Roginskaya V, Van Houten B, Wipf P.

Bioorg Med Chem Lett. 2015 Feb 15;25(4):856-63. doi: 10.1016/j.bmcl.2014.12.072. Epub 2014 Dec 30.


Kinetic gating mechanism of DNA damage recognition by Rad4/XPC.

Chen X, Velmurugu Y, Zheng G, Park B, Shim Y, Kim Y, Liu L, Van Houten B, He C, Ansari A, Min JH.

Nat Commun. 2015 Jan 6;6:5849. doi: 10.1038/ncomms6849.


A novel strategy for targeted killing of tumor cells: Induction of multipolar acentrosomal mitotic spindles with a quinazolinone derivative mdivi-1.

Wang J, Li J, Santana-Santos L, Shuda M, Sobol RW, Van Houten B, Qian W.

Mol Oncol. 2015 Feb;9(2):488-502. doi: 10.1016/j.molonc.2014.10.002. Epub 2014 Oct 17.


Mitochondrial division inhibitor 1 (mdivi-1) enhances death receptor-mediated apoptosis in human ovarian cancer cells.

Wang J, Hansen K, Edwards R, Van Houten B, Qian W.

Biochem Biophys Res Commun. 2015 Jan 2;456(1):7-12. doi: 10.1016/j.bbrc.2014.11.010. Epub 2014 Nov 13.


TAp73 promotes cell survival upon genotoxic stress by inhibiting p53 activity.

Chen D, Ming L, Zou F, Peng Y, Van Houten B, Yu J, Zhang L.

Oncotarget. 2014 Sep 30;5(18):8107-22.


ARTD1/PARP1 negatively regulates glycolysis by inhibiting hexokinase 1 independent of NAD+ depletion.

Fouquerel E, Goellner EM, Yu Z, Gagné JP, Barbi de Moura M, Feinstein T, Wheeler D, Redpath P, Li J, Romero G, Migaud M, Van Houten B, Poirier GG, Sobol RW.

Cell Rep. 2014 Sep 25;8(6):1819-31. doi: 10.1016/j.celrep.2014.08.036. Epub 2014 Sep 15.


Overexpression of mitochondrial sirtuins alters glycolysis and mitochondrial function in HEK293 cells.

de Moura MB, Uppala R, Zhang Y, Van Houten B, Goetzman ES.

PLoS One. 2014 Aug 28;9(8):e106028. doi: 10.1371/journal.pone.0106028. eCollection 2014.


Mitochondria, energetics, epigenetics, and cellular responses to stress.

Shaughnessy DT, McAllister K, Worth L, Haugen AC, Meyer JN, Domann FE, Van Houten B, Mostoslavsky R, Bultman SJ, Baccarelli AA, Begley TJ, Sobol RW, Hirschey MD, Ideker T, Santos JH, Copeland WC, Tice RR, Balshaw DM, Tyson FL.

Environ Health Perspect. 2014 Dec;122(12):1271-8. doi: 10.1289/ehp.1408418. Epub 2014 Aug 15.


Quantifying metabolic heterogeneity in head and neck tumors in real time: 2-DG uptake is highest in hypoxic tumor regions.

Nakajima EC, Laymon C, Oborski M, Hou W, Wang L, Grandis JR, Ferris RL, Mountz JM, Van Houten B.

PLoS One. 2014 Aug 15;9(8):e102452. doi: 10.1371/journal.pone.0102452. eCollection 2014.


Single molecule approaches: watching DNA repair one molecule at a time. Preface.

Kad NM, Van Houten B.

DNA Repair (Amst). 2014 Aug;20:1. doi: 10.1016/j.dnarep.2014.06.007. No abstract available.


Mitochondrial DNA damage: molecular marker of vulnerable nigral neurons in Parkinson's disease.

Sanders LH, McCoy J, Hu X, Mastroberardino PG, Dickinson BC, Chang CJ, Chu CT, Van Houten B, Greenamyre JT.

Neurobiol Dis. 2014 Oct;70:214-23. doi: 10.1016/j.nbd.2014.06.014. Epub 2014 Jun 27.


Novel combination of mitochondrial division inhibitor 1 (mdivi-1) and platinum agents produces synergistic pro-apoptotic effect in drug resistant tumor cells.

Qian W, Wang J, Roginskaya V, McDermott LA, Edwards RP, Stolz DB, Llambi F, Green DR, Van Houten B.

Oncotarget. 2014 Jun 30;5(12):4180-94.


High mobility group box 1 (HMGB1) phenotypic role revealed with stress.

Tang D, Kang R, Van Houten B, Zeh HJ, Billiar TR, Lotze MT.

Mol Med. 2014 Aug 19;20:359-62. doi: 10.2119/molmed.2014.00063.


Single molecule techniques in DNA repair: a primer.

Hughes CD, Simons M, Mackenzie CE, Van Houten B, Kad NM.

DNA Repair (Amst). 2014 Aug;20:2-13. doi: 10.1016/j.dnarep.2014.02.003. Epub 2014 May 10. Review.


Single-molecule analysis reveals human UV-damaged DNA-binding protein (UV-DDB) dimerizes on DNA via multiple kinetic intermediates.

Ghodke H, Wang H, Hsieh CL, Woldemeskel S, Watkins SC, Rapić-Otrin V, Van Houten B.

Proc Natl Acad Sci U S A. 2014 May 6;111(18):E1862-71. doi: 10.1073/pnas.1323856111. Epub 2014 Apr 23.


Nucleotide excision repair in Trypanosoma brucei: specialization of transcription-coupled repair due to multigenic transcription.

Machado CR, Vieira-da-Rocha JP, Mendes IC, Rajão MA, Marcello L, Bitar M, Drummond MG, Grynberg P, Oliveira DA, Marques C, Van Houten B, McCulloch R.

Mol Microbiol. 2014 May;92(4):756-76. doi: 10.1111/mmi.12589. Epub 2014 Apr 24.


Bioenergetic analysis of intact mammalian cells using the Seahorse XF24 Extracellular Flux analyzer and a luciferase ATP assay.

de Moura MB, Van Houten B.

Methods Mol Biol. 2014;1105:589-602. doi: 10.1007/978-1-62703-739-6_40.


Quantitative PCR-based measurement of nuclear and mitochondrial DNA damage and repair in mammalian cells.

Furda A, Santos JH, Meyer JN, Van Houten B.

Methods Mol Biol. 2014;1105:419-37. doi: 10.1007/978-1-62703-739-6_31.


Transcriptional pausing to scout ahead for DNA damage.

Van Houten B, Kisker C.

Proc Natl Acad Sci U S A. 2014 Mar 18;111(11):3905-6. doi: 10.1073/pnas.1402020111. Epub 2014 Mar 5. No abstract available.

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