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Results: 1 to 20 of 75

1.

Knowledge sharing to facilitate regulatory decision-making in regard to alternatives to animal testing: Report of an EPAA workshop.

Ramirez T, Beken S, Chlebus M, Ellis G, Griesinger C, De Jonghe S, Manou I, Mehling A, Reisinger K, Rossi LH, van Benthem J, van der Laan JW, Weissenhorn R, Sauer UG.

Regul Toxicol Pharmacol. 2015 Jul 15;73(1):210-226. doi: 10.1016/j.yrtph.2015.07.007. [Epub ahead of print]

PMID:
26188116
2.

Alternative signaling network activation through different insulin receptor family members caused by pro-mitogenic antidiabetic insulin analogues in human mammary epithelial cells.

Ter Braak B, Wink S, Koedoot E, Pont C, Siezen C, van der Laan JW, van de Water B.

Breast Cancer Res. 2015 Jul 19;17:97. doi: 10.1186/s13058-015-0600-5.

3.

Mammary gland tumor promotion by chronic administration of IGF1 and the insulin analogue AspB10 in the p53R270H/⁺WAPCre mouse model.

ter Braak B, Siezen C, Speksnijder EN, Koedoot E, van Steeg H, Salvatori DC, van de Water B, van der Laan JW.

Breast Cancer Res. 2015 Feb 18;17:14. doi: 10.1186/s13058-015-0518-y.

4.

Safety of vaccine adjuvants: focus on autoimmunity.

van der Laan JW, Gould S, Tanir JY; ILSI HESI Vaccines and Adjuvants Safety Project Committee.

Vaccine. 2015 Mar 24;33(13):1507-14. doi: 10.1016/j.vaccine.2015.01.073. Epub 2015 Feb 7.

5.

Biosimilars entering the clinic without animal studies. A paradigm shift in the European Union.

van Aerts LA, De Smet K, Reichmann G, van der Laan JW, Schneider CK.

MAbs. 2014;6(5):1155-62. doi: 10.4161/mabs.29848.

PMID:
25517301
6.

Toward a comparative retrospective analysis of rat and rabbit developmental toxicity studies for pharmaceutical compounds.

Theunissen PT, Beken S, Cappon GD, Chen C, Hoberman AM, van der Laan JW, Stewart J, Piersma AH.

Reprod Toxicol. 2014 Aug;47:27-32.

PMID:
25517003
7.

Advancing the 3Rs in regulatory toxicology - Carcinogenicity testing: Scope for harmonisation and advancing the 3Rs in regulated sectors of the European Union.

Annys E, Billington R, Clayton R, Bremm KD, Graziano M, McKelvie J, Ragan I, Schwarz M, van der Laan JW, Wood C, Öberg M, Wester P, Woodward KN.

Regul Toxicol Pharmacol. 2014 Jul;69(2):234-42. doi: 10.1016/j.yrtph.2014.04.009. Epub 2014 Apr 24.

PMID:
24768934
8.

Classifying the adverse mitogenic mode of action of insulin analogues using a novel mechanism-based genetically engineered human breast cancer cell panel.

ter Braak B, Siezen CL, Kannegieter N, Koedoot E, van de Water B, van der Laan JW.

Arch Toxicol. 2014 Apr;88(4):953-66. doi: 10.1007/s00204-014-1201-2. Epub 2014 Jan 25.

PMID:
24464500
9.

Approaches and considerations for the assessment of immunotoxicity for environmental chemicals: a workshop summary.

Boverhof DR, Ladics G, Luebke B, Botham J, Corsini E, Evans E, Germolec D, Holsapple M, Loveless SE, Lu H, van der Laan JW, White KL Jr, Yang Y.

Regul Toxicol Pharmacol. 2014 Feb;68(1):96-107. doi: 10.1016/j.yrtph.2013.11.012. Epub 2013 Nov 23.

10.

The value of non-human primates in the development of monoclonal antibodies.

van Meer PJ, Kooijman M, van der Laan JW, Moors EH, Schellekens H.

Nat Biotechnol. 2013 Oct;31(10):882-3. doi: 10.1038/nbt.2709. No abstract available.

PMID:
24104750
11.

Challenges and approaches for the development of safer immunomodulatory biologics.

Sathish JG, Sethu S, Bielsky MC, de Haan L, French NS, Govindappa K, Green J, Griffiths CE, Holgate S, Jones D, Kimber I, Moggs J, Naisbitt DJ, Pirmohamed M, Reichmann G, Sims J, Subramanyam M, Todd MD, Van Der Laan JW, Weaver RJ, Park BK.

Nat Rev Drug Discov. 2013 Apr;12(4):306-24. doi: 10.1038/nrd3974. Review.

PMID:
23535934
12.

Response to 'Statins accelerate the onset of collagen type II-induced arthritis in mice'-authors' reply.

Vandebriel RJ, De Jong HJ, Gremmer ER, Klungel OH, Tervaert JW, Slob W, Van Der Laan JW, Van Loveren H.

Arthritis Res Ther. 2013 Mar 8;15(2):403. doi: 10.1186/ar4170. No abstract available.

13.

Statins accelerate the onset of collagen type II-induced arthritis in mice.

Vandebriel RJ, De Jong HJ, Gremmer ER, Klungel OH, Tervaert JW, Slob W, Van Der Laan JW, Van Loveren H.

Arthritis Res Ther. 2012 Apr 26;14(2):R90. doi: 10.1186/ar3814.

14.

Testing strategies for embryo-fetal toxicity of human pharmaceuticals. Animal models vs. in vitro approaches: a workshop report.

van der Laan JW, Chapin RE, Haenen B, Jacobs AC, Piersma A.

Regul Toxicol Pharmacol. 2012 Jun;63(1):115-23. doi: 10.1016/j.yrtph.2012.03.009. Epub 2012 Mar 16.

PMID:
22449444
15.

What it means to be global.

Roberts RA, Wallis R, Ren J, van der Laan JW, Sausen PJ, Slikker W Jr.

Toxicol Sci. 2012 May;127(1):313-4. doi: 10.1093/toxsci/kfs079. Epub 2012 Feb 14. No abstract available.

16.

Use of statins is associated with an increased risk of rheumatoid arthritis.

de Jong HJ, Klungel OH, van Dijk L, Vandebriel RJ, Leufkens HG, van der Laan JW, Cohen Tervaert JW, van Loveren H.

Ann Rheum Dis. 2012 May;71(5):648-54. doi: 10.1136/ard.2011.155622. Epub 2011 Oct 6.

PMID:
21979000
17.

New adjuvanted vaccines in pregnancy: what is known about their safety?

Herberts C, Melgert B, van der Laan JW, Faas M.

Expert Rev Vaccines. 2010 Dec;9(12):1411-22. doi: 10.1586/erv.10.133. Review.

PMID:
21105777
18.

Human and environmental health challenges for the next decade (2010–2020).

Bonnefoi MS, Belanger SE, Devlin DJ, Doerrer NG, Embry MR, Fukushima S, Harpur ES, Hines RN, Holsapple MP, Kim JH, MacDonald JS, O'Lone R, Pettit SD, Stevens JL, Takei AS, Tinkle SS, van der Laan JW.

Crit Rev Toxicol. 2010 Nov;40(10):893-911. doi: 10.3109/10408444.2010.506640. Review.

PMID:
20854192
19.

The RETHINK project--minipigs as models for the toxicity testing of new medicines and chemicals: an impact assessment.

Forster R, Bode G, Ellegaard L, van der Laan JW; Steering Group of the RETHINK Project.

J Pharmacol Toxicol Methods. 2010 Nov-Dec;62(3):158-9. doi: 10.1016/j.vascn.2010.05.003. Epub 2010 Jun 1.

PMID:
20685395
20.

The RETHINK project on minipigs in the toxicity testing of new medicines and chemicals: conclusions and recommendations.

Forster R, Bode G, Ellegaard L, van der Laan JW.

J Pharmacol Toxicol Methods. 2010 Nov-Dec;62(3):236-42. doi: 10.1016/j.vascn.2010.05.008. Epub 2010 May 31. Review.

PMID:
20685309
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