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Results: 1 to 20 of 158

1.

Discovery, synthesis, and optimization of antimalarial 4(1H)-quinolone-3-diarylethers.

Nilsen A, Miley GP, Forquer IP, Mather MW, Katneni K, Li Y, Pou S, Pershing AM, Stickles AM, Ryan E, Kelly JX, Doggett JS, White KL, Hinrichs DJ, Winter RW, Charman SA, Zakharov LN, Bathurst I, Burrows JN, Vaidya AB, Riscoe MK.

J Med Chem. 2014 May 8;57(9):3818-34. doi: 10.1021/jm500147k. Epub 2014 Apr 18.

PMID:
24720377
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

The metabolic roles of the endosymbiotic organelles of Toxoplasma and Plasmodium spp.

Sheiner L, Vaidya AB, McFadden GI.

Curr Opin Microbiol. 2013 Aug;16(4):452-8. doi: 10.1016/j.mib.2013.07.003. Epub 2013 Aug 5. Review.

PMID:
23927894
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Shirodhara: A psycho-physiological profile in healthy volunteers.

Dhuri KD, Bodhe PV, Vaidya AB.

J Ayurveda Integr Med. 2013 Jan;4(1):40-4. doi: 10.4103/0975-9476.109550.

PMID:
23741161
[PubMed]
Free PMC Article
4.

Retraction: Branched tricarboxylic acid metabolism in Plasmodium falciparum.

Olszewski KL, Mather MW, Morrisey JM, Garcia BA, Vaidya AB, Rabinowitz JD, Llinás M.

Nature. 2013 May 30;497(7451):652. doi: 10.1038/nature12164. Epub 2013 Apr 24. No abstract available.

PMID:
23615611
[PubMed - indexed for MEDLINE]
5.

Quinolone-3-diarylethers: a new class of antimalarial drug.

Nilsen A, LaCrue AN, White KL, Forquer IP, Cross RM, Marfurt J, Mather MW, Delves MJ, Shackleford DM, Saenz FE, Morrisey JM, Steuten J, Mutka T, Li Y, Wirjanata G, Ryan E, Duffy S, Kelly JX, Sebayang BF, Zeeman AM, Noviyanti R, Sinden RE, Kocken CH, Price RN, Avery VM, Angulo-Barturen I, Jiménez-Díaz MB, Ferrer S, Herreros E, Sanz LM, Gamo FJ, Bathurst I, Burrows JN, Siegl P, Guy RK, Winter RW, Vaidya AB, Charman SA, Kyle DE, Manetsch R, Riscoe MK.

Sci Transl Med. 2013 Mar 20;5(177):177ra37. doi: 10.1126/scitranslmed.3005029.

PMID:
23515079
[PubMed - indexed for MEDLINE]
Free Article
6.

The antimalarial activities of methylene blue and the 1,4-naphthoquinone 3-[4-(trifluoromethyl)benzyl]-menadione are not due to inhibition of the mitochondrial electron transport chain.

Ehrhardt K, Davioud-Charvet E, Ke H, Vaidya AB, Lanzer M, Deponte M.

Antimicrob Agents Chemother. 2013 May;57(5):2114-20. doi: 10.1128/AAC.02248-12. Epub 2013 Feb 25.

PMID:
23439633
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Exploratory study to evaluate tolerability, safety, and activity of Ashwagandha (Withania somnifera) in healthy volunteers.

Raut AA, Rege NN, Tadvi FM, Solanki PV, Kene KR, Shirolkar SG, Pandey SN, Vaidya RA, Vaidya AB.

J Ayurveda Integr Med. 2012 Jul;3(3):111-4. doi: 10.4103/0975-9476.100168.

PMID:
23125505
[PubMed]
Free PMC Article
8.

Remarkable stability in patterns of blood-stage gene expression during episodes of non-lethal Plasmodium yoelii malaria.

Cernetich-Ott A, Daly TM, Vaidya AB, Bergman LW, Burns JM Jr.

Malar J. 2012 Aug 6;11:265. doi: 10.1186/1475-2875-11-265.

PMID:
22866913
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Mitochondrial RNA polymerase is an essential enzyme in erythrocytic stages of Plasmodium falciparum.

Ke H, Morrisey JM, Ganesan SM, Mather MW, Vaidya AB.

Mol Biochem Parasitol. 2012 Sep;185(1):48-51. doi: 10.1016/j.molbiopara.2012.05.001. Epub 2012 May 26.

PMID:
22640832
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Crystal structure of GAP50, the anchor of the invasion machinery in the inner membrane complex of Plasmodium falciparum.

Bosch J, Paige MH, Vaidya AB, Bergman LW, Hol WG.

J Struct Biol. 2012 Apr;178(1):61-73. doi: 10.1016/j.jsb.2012.02.009. Epub 2012 Feb 22.

PMID:
22387043
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Comparative genomics of the pathogenic ciliate Ichthyophthirius multifiliis, its free-living relatives and a host species provide insights into adoption of a parasitic lifestyle and prospects for disease control.

Coyne RS, Hannick L, Shanmugam D, Hostetler JB, Brami D, Joardar VS, Johnson J, Radune D, Singh I, Badger JH, Kumar U, Saier M, Wang Y, Cai H, Gu J, Mather MW, Vaidya AB, Wilkes DE, Rajagopalan V, Asai DJ, Pearson CG, Findly RC, Dickerson HW, Wu M, Martens C, Van de Peer Y, Roos DS, Cassidy-Hanley DM, Clark TG.

Genome Biol. 2011 Oct 17;12(10):R100. doi: 10.1186/gb-2011-12-10-r100.

PMID:
22004680
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

ATP synthase complex of Plasmodium falciparum: dimeric assembly in mitochondrial membranes and resistance to genetic disruption.

Balabaskaran Nina P, Morrisey JM, Ganesan SM, Ke H, Pershing AM, Mather MW, Vaidya AB.

J Biol Chem. 2011 Dec 2;286(48):41312-22. doi: 10.1074/jbc.M111.290973. Epub 2011 Oct 7.

PMID:
21984828
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

A chemical genomic analysis of decoquinate, a Plasmodium falciparum cytochrome b inhibitor.

Nam TG, McNamara CW, Bopp S, Dharia NV, Meister S, Bonamy GM, Plouffe DM, Kato N, McCormack S, Bursulaya B, Ke H, Vaidya AB, Schultz PG, Winzeler EA.

ACS Chem Biol. 2011 Nov 18;6(11):1214-22. doi: 10.1021/cb200105d. Epub 2011 Sep 8.

PMID:
21866942
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Variation among Plasmodium falciparum strains in their reliance on mitochondrial electron transport chain function.

Ke H, Morrisey JM, Ganesan SM, Painter HJ, Mather MW, Vaidya AB.

Eukaryot Cell. 2011 Aug;10(8):1053-61. doi: 10.1128/EC.05049-11. Epub 2011 Jun 17.

PMID:
21685321
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Yeast dihydroorotate dehydrogenase as a new selectable marker for Plasmodium falciparum transfection.

Ganesan SM, Morrisey JM, Ke H, Painter HJ, Laroiya K, Phillips MA, Rathod PK, Mather MW, Vaidya AB.

Mol Biochem Parasitol. 2011 May;177(1):29-34. doi: 10.1016/j.molbiopara.2011.01.004. Epub 2011 Jan 18.

PMID:
21251930
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Chemopreventive potential and safety profile of a Curcuma longa extract in women with cervical low-grade squamous intraepithelial neoplasia.

Joshi JV, Paradkar PH, Jagtap SS, Agashe SV, Soman G, Vaidya AB.

Asian Pac J Cancer Prev. 2011;12(12):3305-11.

PMID:
22471471
[PubMed - indexed for MEDLINE]
Free Article
17.

Mitochondrial electron transport inhibition and viability of intraerythrocytic Plasmodium falciparum.

Painter HJ, Morrisey JM, Vaidya AB.

Antimicrob Agents Chemother. 2010 Dec;54(12):5281-7. doi: 10.1128/AAC.00937-10. Epub 2010 Sep 20.

PMID:
20855748
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Branched tricarboxylic acid metabolism in Plasmodium falciparum.

Olszewski KL, Mather MW, Morrisey JM, Garcia BA, Vaidya AB, Rabinowitz JD, Llinás M.

Nature. 2010 Aug 5;466(7307):774-8. doi: 10.1038/nature09301. Erratum in: Nature. 2011 Jan 20;469(7330):432. Retraction in: Olszewski KL, Mather MW, Morrisey JM, Garcia BA, Vaidya AB, Rabinowitz JD, Llinás M. Nature. 2013 May 30;497(7451):652.

PMID:
20686576
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Hemozoin-free Plasmodium falciparum mitochondria for physiological and drug susceptibility studies.

Mather MW, Morrisey JM, Vaidya AB.

Mol Biochem Parasitol. 2010 Dec;174(2):150-3. doi: 10.1016/j.molbiopara.2010.07.006. Epub 2010 Jul 30.

PMID:
20674615
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Highly divergent mitochondrial ATP synthase complexes in Tetrahymena thermophila.

Balabaskaran Nina P, Dudkina NV, Kane LA, van Eyk JE, Boekema EJ, Mather MW, Vaidya AB.

PLoS Biol. 2010 Jul 13;8(7):e1000418. doi: 10.1371/journal.pbio.1000418.

PMID:
20644710
[PubMed - indexed for MEDLINE]
Free PMC Article

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