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Results: 1 to 20 of 166

1.

ELQ-300 Prodrugs for Enhanced Delivery and Single-Dose Cure of Malaria.

Miley GP, Pou S, Winter R, Nilsen A, Li Y, Kelly JX, Stickles AM, Mather MW, Forquer IP, Pershing AM, White K, Shackleford D, Saunders J, Chen G, Ting LM, Kim K, Zakharov LN, Donini C, Burrows JN, Vaidya AB, Charman SA, Riscoe MK.

Antimicrob Agents Chemother. 2015 Sep;59(9):5555-60. doi: 10.1128/AAC.01183-15. Epub 2015 Jun 29.

PMID:
26124159
2.

Inhibition of cytochrome bc1 as a strategy for single-dose, multi-stage antimalarial therapy.

Stickles AM, Ting LM, Morrisey JM, Li Y, Mather MW, Meermeier E, Pershing AM, Forquer IP, Miley GP, Pou S, Winter RW, Hinrichs DJ, Kelly JX, Kim K, Vaidya AB, Riscoe MK, Nilsen A.

Am J Trop Med Hyg. 2015 Jun;92(6):1195-201. doi: 10.4269/ajtmh.14-0553. Epub 2015 Apr 27.

PMID:
25918204
3.

Genetic investigation of tricarboxylic acid metabolism during the Plasmodium falciparum life cycle.

Ke H, Lewis IA, Morrisey JM, McLean KJ, Ganesan SM, Painter HJ, Mather MW, Jacobs-Lorena M, Llinás M, Vaidya AB.

Cell Rep. 2015 Apr 7;11(1):164-74. doi: 10.1016/j.celrep.2015.03.011. Epub 2015 Apr 2.

4.

Host erythrocyte environment influences the localization of exported protein 2, an essential component of the Plasmodium translocon.

Meibalan E, Comunale MA, Lopez AM, Bergman LW, Mehta A, Vaidya AB, Burns JM Jr.

Eukaryot Cell. 2015 Apr;14(4):371-84. doi: 10.1128/EC.00228-14. Epub 2015 Feb 6.

PMID:
25662767
5.

Subtle changes in endochin-like quinolone structure alter the site of inhibition within the cytochrome bc1 complex of Plasmodium falciparum.

Stickles AM, de Almeida MJ, Morrisey JM, Sheridan KA, Forquer IP, Nilsen A, Winter RW, Burrows JN, Fidock DA, Vaidya AB, Riscoe MK.

Antimicrob Agents Chemother. 2015 Apr;59(4):1977-82. doi: 10.1128/AAC.04149-14. Epub 2015 Jan 20.

PMID:
25605352
6.

Pyrazoleamide compounds are potent antimalarials that target Na+ homeostasis in intraerythrocytic Plasmodium falciparum.

Vaidya AB, Morrisey JM, Zhang Z, Das S, Daly TM, Otto TD, Spillman NJ, Wyvratt M, Siegl P, Marfurt J, Wirjanata G, Sebayang BF, Price RN, Chatterjee A, Nagle A, Stasiak M, Charman SA, Angulo-Barturen I, Ferrer S, Belén Jiménez-Díaz M, Martínez MS, Gamo FJ, Avery VM, Ruecker A, Delves M, Kirk K, Berriman M, Kortagere S, Burrows J, Fan E, Bergman LW.

Nat Commun. 2014 Nov 25;5:5521. doi: 10.1038/ncomms6521.

7.

The heme biosynthesis pathway is essential for Plasmodium falciparum development in mosquito stage but not in blood stages.

Ke H, Sigala PA, Miura K, Morrisey JM, Mather MW, Crowley JR, Henderson JP, Goldberg DE, Long CA, Vaidya AB.

J Biol Chem. 2014 Dec 12;289(50):34827-37. doi: 10.1074/jbc.M114.615831. Epub 2014 Oct 28.

PMID:
25352601
8.

Antirelapse Efficacy of Various Primaquine Regimens for Plasmodium vivax.

Rajgor DD, Gogtay NJ, Kadam VS, Kocharekar MM, Parulekar MS, Dalvi SS, Vaidya AB, Kshirsagar NA.

Malar Res Treat. 2014;2014:347018. doi: 10.1155/2014/347018. Epub 2014 Sep 10.

9.

Discovery, synthesis, and optimization of antimalarial 4(1H)-quinolone-3-diarylethers.

Nilsen A, Miley GP, Forquer IP, Mather MW, Katneni K, Li Y, Pou S, Pershing AM, Stickles AM, Ryan E, Kelly JX, Doggett JS, White KL, Hinrichs DJ, Winter RW, Charman SA, Zakharov LN, Bathurst I, Burrows JN, Vaidya AB, Riscoe MK.

J Med Chem. 2014 May 8;57(9):3818-34. doi: 10.1021/jm500147k. Epub 2014 Apr 18.

10.

The metabolic roles of the endosymbiotic organelles of Toxoplasma and Plasmodium spp.

Sheiner L, Vaidya AB, McFadden GI.

Curr Opin Microbiol. 2013 Aug;16(4):452-8. doi: 10.1016/j.mib.2013.07.003. Epub 2013 Aug 5. Review.

11.

Shirodhara: A psycho-physiological profile in healthy volunteers.

Dhuri KD, Bodhe PV, Vaidya AB.

J Ayurveda Integr Med. 2013 Jan;4(1):40-4. doi: 10.4103/0975-9476.109550.

12.

Retraction: Branched tricarboxylic acid metabolism in Plasmodium falciparum.

Olszewski KL, Mather MW, Morrisey JM, Garcia BA, Vaidya AB, Rabinowitz JD, Llinás M.

Nature. 2013 May 30;497(7451):652. doi: 10.1038/nature12164. Epub 2013 Apr 24. No abstract available.

13.

Quinolone-3-diarylethers: a new class of antimalarial drug.

Nilsen A, LaCrue AN, White KL, Forquer IP, Cross RM, Marfurt J, Mather MW, Delves MJ, Shackleford DM, Saenz FE, Morrisey JM, Steuten J, Mutka T, Li Y, Wirjanata G, Ryan E, Duffy S, Kelly JX, Sebayang BF, Zeeman AM, Noviyanti R, Sinden RE, Kocken CH, Price RN, Avery VM, Angulo-Barturen I, Jiménez-Díaz MB, Ferrer S, Herreros E, Sanz LM, Gamo FJ, Bathurst I, Burrows JN, Siegl P, Guy RK, Winter RW, Vaidya AB, Charman SA, Kyle DE, Manetsch R, Riscoe MK.

Sci Transl Med. 2013 Mar 20;5(177):177ra37. doi: 10.1126/scitranslmed.3005029.

14.

The antimalarial activities of methylene blue and the 1,4-naphthoquinone 3-[4-(trifluoromethyl)benzyl]-menadione are not due to inhibition of the mitochondrial electron transport chain.

Ehrhardt K, Davioud-Charvet E, Ke H, Vaidya AB, Lanzer M, Deponte M.

Antimicrob Agents Chemother. 2013 May;57(5):2114-20. doi: 10.1128/AAC.02248-12. Epub 2013 Feb 25.

15.

Exploratory study to evaluate tolerability, safety, and activity of Ashwagandha (Withania somnifera) in healthy volunteers.

Raut AA, Rege NN, Tadvi FM, Solanki PV, Kene KR, Shirolkar SG, Pandey SN, Vaidya RA, Vaidya AB.

J Ayurveda Integr Med. 2012 Jul;3(3):111-4. doi: 10.4103/0975-9476.100168.

16.

Remarkable stability in patterns of blood-stage gene expression during episodes of non-lethal Plasmodium yoelii malaria.

Cernetich-Ott A, Daly TM, Vaidya AB, Bergman LW, Burns JM Jr.

Malar J. 2012 Aug 6;11:265. doi: 10.1186/1475-2875-11-265.

17.

Mitochondrial RNA polymerase is an essential enzyme in erythrocytic stages of Plasmodium falciparum.

Ke H, Morrisey JM, Ganesan SM, Mather MW, Vaidya AB.

Mol Biochem Parasitol. 2012 Sep;185(1):48-51. doi: 10.1016/j.molbiopara.2012.05.001. Epub 2012 May 26.

18.

Crystal structure of GAP50, the anchor of the invasion machinery in the inner membrane complex of Plasmodium falciparum.

Bosch J, Paige MH, Vaidya AB, Bergman LW, Hol WG.

J Struct Biol. 2012 Apr;178(1):61-73. doi: 10.1016/j.jsb.2012.02.009. Epub 2012 Feb 22.

19.

Comparative genomics of the pathogenic ciliate Ichthyophthirius multifiliis, its free-living relatives and a host species provide insights into adoption of a parasitic lifestyle and prospects for disease control.

Coyne RS, Hannick L, Shanmugam D, Hostetler JB, Brami D, Joardar VS, Johnson J, Radune D, Singh I, Badger JH, Kumar U, Saier M, Wang Y, Cai H, Gu J, Mather MW, Vaidya AB, Wilkes DE, Rajagopalan V, Asai DJ, Pearson CG, Findly RC, Dickerson HW, Wu M, Martens C, Van de Peer Y, Roos DS, Cassidy-Hanley DM, Clark TG.

Genome Biol. 2011 Oct 17;12(10):R100. doi: 10.1186/gb-2011-12-10-r100.

20.

ATP synthase complex of Plasmodium falciparum: dimeric assembly in mitochondrial membranes and resistance to genetic disruption.

Balabaskaran Nina P, Morrisey JM, Ganesan SM, Ke H, Pershing AM, Mather MW, Vaidya AB.

J Biol Chem. 2011 Dec 2;286(48):41312-22. doi: 10.1074/jbc.M111.290973. Epub 2011 Oct 7.

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