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Year Number of Results
1970 1
1974 1
1980 2
1983 2
1984 2
1985 3
1986 2
1987 4
1989 2
1990 4
1991 2
1992 3
1993 5
1994 1
1995 6
1996 5
1997 12
1998 8
1999 6
2000 8
2001 13
2002 10
2003 14
2004 19
2005 15
2006 11
2007 15
2008 12
2009 15
2010 17
2011 23
2012 14
2013 23
2014 19
2015 18
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2017 24
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2020 26
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2023 28
2024 10

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501 results

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Page 1
VapA of Rhodococcus equi binds phosphatidic acid.
Wright LM, Carpinone EM, Bennett TL, Hondalus MK, Starai VJ. Wright LM, et al. Mol Microbiol. 2018 Feb;107(3):428-444. doi: 10.1111/mmi.13892. Epub 2017 Dec 22. Mol Microbiol. 2018. PMID: 29205554 Free PMC article.
Previous studies determined that the major virulence determinant of R. equi is the surface bound virulence associated protein A (VapA). The presence of VapA inhibits the maturation of R. equi-containing phagosomes and promotes intracellular bacterial survival, as de …
Previous studies determined that the major virulence determinant of R. equi is the surface bound virulence associated protein A (VapA …
Large Oncosome-Loaded VAPA Promotes Bone-Tropic Metastasis of Hepatocellular Carcinoma Via Formation of Osteoclastic Pre-Metastatic Niche.
Zhang S, Liao X, Chen S, Qian W, Li M, Xu Y, Yang M, Li X, Mo S, Tang M, Wu X, Hu Y, Li Z, Yu R, Abudourousuli A, Song L, Li J. Zhang S, et al. Adv Sci (Weinh). 2022 Nov;9(31):e2201974. doi: 10.1002/advs.202201974. Epub 2022 Sep 28. Adv Sci (Weinh). 2022. PMID: 36169100 Free PMC article.
VAPA-enriched LOs-induced pre-metastatic education transforms the bone into a fertile milieu, which supports the growth of metastatic HCC cells. ...Importantly, treatment with N-WASP inhibitor 187-1-packaged LOs (LOs/187-1) dramatically abolishes the inductive effect of …
VAPA-enriched LOs-induced pre-metastatic education transforms the bone into a fertile milieu, which supports the growth of metastatic …
Calcium transients on the ER surface trigger liquid-liquid phase separation of FIP200 to specify autophagosome initiation sites.
Zheng Q, Chen Y, Chen D, Zhao H, Feng Y, Meng Q, Zhao Y, Zhang H. Zheng Q, et al. Cell. 2022 Oct 27;185(22):4082-4098.e22. doi: 10.1016/j.cell.2022.09.001. Epub 2022 Oct 4. Cell. 2022. PMID: 36198318 Free article.
Multiple FIP200 puncta on the ER, whose association depends on the ER proteins VAPA/B and ATL2/3, assemble into autophagosome formation sites. Thus, Ca(2+) transients are crucial for triggering phase separation of FIP200 to specify autophagosome initiation sites in metazoa …
Multiple FIP200 puncta on the ER, whose association depends on the ER proteins VAPA/B and ATL2/3, assemble into autophagosome formati …
ER-lysosome contacts enable cholesterol sensing by mTORC1 and drive aberrant growth signalling in Niemann-Pick type C.
Lim CY, Davis OB, Shin HR, Zhang J, Berdan CA, Jiang X, Counihan JL, Ory DS, Nomura DK, Zoncu R. Lim CY, et al. Nat Cell Biol. 2019 Oct;21(10):1206-1218. doi: 10.1038/s41556-019-0391-5. Epub 2019 Sep 23. Nat Cell Biol. 2019. PMID: 31548609 Free PMC article.
Here, we show that oxysterol binding protein (OSBP) and its anchors at the endoplasmic reticulum (ER), VAPA and VAPB, deliver cholesterol across ER-lysosome contacts to activate mTORC1. ...
Here, we show that oxysterol binding protein (OSBP) and its anchors at the endoplasmic reticulum (ER), VAPA and VAPB, deliver cholest …
Cholesterol transfer via endoplasmic reticulum contacts mediates lysosome damage repair.
Radulovic M, Wenzel EM, Gilani S, Holland LK, Lystad AH, Phuyal S, Olkkonen VM, Brech A, Jäättelä M, Maeda K, Raiborg C, Stenmark H. Radulovic M, et al. EMBO J. 2022 Dec 15;41(24):e112677. doi: 10.15252/embj.2022112677. Epub 2022 Nov 21. EMBO J. 2022. PMID: 36408828 Free PMC article.
Electron microscopy demonstrated that lysosomal membrane damage is rapidly followed by the formation of contacts with the endoplasmic reticulum (ER), which depends on the ER proteins VAPA/B. The cholesterol-binding protein ORP1L was recruited to damaged lysosomes, accompan …
Electron microscopy demonstrated that lysosomal membrane damage is rapidly followed by the formation of contacts with the endoplasmic reticu …
Isolation and identification of vapA-absent Aeromonas salmonicida in diseased snakehead Channa argus in China.
Sun XN, Wang Q, Wang YF, Tao Y, Zheng CL, Wang MH, Che MY, Cui ZH, Li XL, Zhang Q, Xu MX, Wang S, Nie P, Sun YL. Sun XN, et al. Int Microbiol. 2023 Dec 8. doi: 10.1007/s10123-023-00455-w. Online ahead of print. Int Microbiol. 2023. PMID: 38062211
The Virulence array protein gene cloning' results suggested that As-s has this gene compared with the other two vapA-containing strains, despite a close relationship of these strains via phylogenetic analysis. ...In addition, As-s caused high mortality in snakehead, consis …
The Virulence array protein gene cloning' results suggested that As-s has this gene compared with the other two vapA-containing strai …
Assessment in mice of vapA-DNA vaccination against Rhodococcus equi infection.
Haghighi HR, Prescott JF. Haghighi HR, et al. Vet Immunol Immunopathol. 2005 Apr 8;104(3-4):215-25. doi: 10.1016/j.vetimm.2004.12.006. Vet Immunol Immunopathol. 2005. PMID: 15734542
To assess the potential of vapA-DNA to produce immunity, C57BL/6 and BALB/c mice were immunized with a DNA vaccine constructed from vapA incorporated into pcDNA3.1. ...This effect was more marked when pORF-IL-12, a plasmid expressing murine IL12, was included with t …
To assess the potential of vapA-DNA to produce immunity, C57BL/6 and BALB/c mice were immunized with a DNA vaccine constructed from …
CircVAPA promotes small cell lung cancer progression by modulating the miR-377-3p and miR-494-3p/IGF1R/AKT axis.
Hua J, Wang X, Ma L, Li J, Cao G, Zhang S, Lin W. Hua J, et al. Mol Cancer. 2022 Jun 6;21(1):123. doi: 10.1186/s12943-022-01595-9. Mol Cancer. 2022. PMID: 35668527 Free PMC article.
RESULTS: We revealed that circVAPA, derived from exons 2-4 of the vesicle-associated membrane protein-associated protein A (VAPA) gene, exhibited higher expression levels in SCLC cell lines, clinical tissues, and serum from SCLC patients than the controls, and facilitated …
RESULTS: We revealed that circVAPA, derived from exons 2-4 of the vesicle-associated membrane protein-associated protein A (VAPA) gen …
501 results