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Results: 16

1.

Mapping the cellular response to small molecules using chemogenomic fitness signatures.

Lee AY, St Onge RP, Proctor MJ, Wallace IM, Nile AH, Spagnuolo PA, Jitkova Y, Gronda M, Wu Y, Kim MK, Cheung-Ong K, Torres NP, Spear ED, Han MK, Schlecht U, Suresh S, Duby G, Heisler LE, Surendra A, Fung E, Urbanus ML, Gebbia M, Lissina E, Miranda M, Chiang JH, Aparicio AM, Zeghouf M, Davis RW, Cherfils J, Boutry M, Kaiser CA, Cummins CL, Trimble WS, Brown GW, Schimmer AD, Bankaitis VA, Nislow C, Bader GD, Giaever G.

Science. 2014 Apr 11;344(6180):208-11. doi: 10.1126/science.1250217. Erratum in: Science. 2014 May 23;344(6186):1255771.

2.

A phenotypic screening platform to identify small molecule modulators of Chlamydomonas reinhardtii growth, motility and photosynthesis.

Alfred SE, Surendra A, Le C, Lin K, Mok A, Wallace IM, Proctor M, Urbanus ML, Giaever G, Nislow C.

Genome Biol. 2012 Nov 18;13(11):R105. doi: 10.1186/gb-2012-13-11-r105.

3.

Genome-wide analysis of intracellular pH reveals quantitative control of cell division rate by pH(c) in Saccharomyces cerevisiae.

Orij R, Urbanus ML, Vizeacoumar FJ, Giaever G, Boone C, Nislow C, Brul S, Smits GJ.

Genome Biol. 2012 Sep 10;13(9):R80. doi: 10.1186/gb-2012-13-9-r80.

4.

Dafadine inhibits DAF-9 to promote dauer formation and longevity of Caenorhabditis elegans.

Luciani GM, Magomedova L, Puckrin R, Urbanus ML, Wallace IM, Giaever G, Nislow C, Cummins CL, Roy PJ.

Nat Chem Biol. 2011 Nov 6;7(12):891-3. doi: 10.1038/nchembio.698. Erratum in: Nat Chem Biol. 2012 Mar;8(3):318.

PMID:
22057127
5.

Compound prioritization methods increase rates of chemical probe discovery in model organisms.

Wallace IM, Urbanus ML, Luciani GM, Burns AR, Han MK, Wang H, Arora K, Heisler LE, Proctor M, St Onge RP, Roemer T, Roy PJ, Cummins CL, Bader GD, Nislow C, Giaever G.

Chem Biol. 2011 Oct 28;18(10):1273-83. doi: 10.1016/j.chembiol.2011.07.018.

6.

A systems biology approach reveals the role of a novel methyltransferase in response to chemical stress and lipid homeostasis.

Lissina E, Young B, Urbanus ML, Guan XL, Lowenson J, Hoon S, Baryshnikova A, Riezman I, Michaut M, Riezman H, Cowen LE, Wenk MR, Clarke SG, Giaever G, Nislow C.

PLoS Genet. 2011 Oct;7(10):e1002332. doi: 10.1371/journal.pgen.1002332. Epub 2011 Oct 20.

7.

The automated cell: compound and environment screening system (ACCESS) for chemogenomic screening.

Proctor M, Urbanus ML, Fung EL, Jaramillo DF, Davis RW, Nislow C, Giaever G.

Methods Mol Biol. 2011;759:239-69. doi: 10.1007/978-1-61779-173-4_15.

PMID:
21863492
8.

Detection of cross-links between FtsH, YidC, HflK/C suggests a linked role for these proteins in quality control upon insertion of bacterial inner membrane proteins.

van Bloois E, Dekker HL, Fröderberg L, Houben EN, Urbanus ML, de Koster CG, de Gier JW, Luirink J.

FEBS Lett. 2008 Apr 30;582(10):1419-24. doi: 10.1016/j.febslet.2008.02.082. Epub 2008 Apr 1.

9.

A conserved function of YidC in the biogenesis of respiratory chain complexes.

van der Laan M, Urbanus ML, Ten Hagen-Jongman CM, Nouwen N, Oudega B, Harms N, Driessen AJ, Luirink J.

Proc Natl Acad Sci U S A. 2003 May 13;100(10):5801-6. Epub 2003 Apr 30.

10.

Signal recognition particle (SRP)-mediated targeting and Sec-dependent translocation of an extracellular Escherichia coli protein.

Sijbrandi R, Urbanus ML, ten Hagen-Jongman CM, Bernstein HD, Oudega B, Otto BR, Luirink J.

J Biol Chem. 2003 Feb 14;278(7):4654-9. Epub 2002 Dec 3.

11.

YidC and SecY mediate membrane insertion of a Type I transmembrane domain.

Houben EN, Urbanus ML, Van Der Laan M, Ten Hagen-Jongman CM, Driessen AJ, Brunner J, Oudega B, Luirink J.

J Biol Chem. 2002 Sep 27;277(39):35880-6. Epub 2002 Jul 9.

12.

Targeting, insertion, and localization of Escherichia coli YidC.

Urbanus ML, Fröderberg L, Drew D, Björk P, de Gier JW, Brunner J, Oudega B, Luirink J.

J Biol Chem. 2002 Apr 12;277(15):12718-23. Epub 2002 Jan 30.

13.

Sec-dependent membrane protein insertion: sequential interaction of nascent FtsQ with SecY and YidC.

Urbanus ML, Scotti PA, Froderberg L, Saaf A, de Gier JW, Brunner J, Samuelson JC, Dalbey RE, Oudega B, Luirink J.

EMBO Rep. 2001 Jun;2(6):524-9.

14.

YidC, the Escherichia coli homologue of mitochondrial Oxa1p, is a component of the Sec translocase.

Scotti PA, Urbanus ML, Brunner J, de Gier JW, von Heijne G, van der Does C, Driessen AJ, Oudega B, Luirink J.

EMBO J. 2000 Feb 15;19(4):542-9.

15.

SecA is not required for signal recognition particle-mediated targeting and initial membrane insertion of a nascent inner membrane protein.

Scotti PA, Valent QA, Manting EH, Urbanus ML, Driessen AJ, Oudega B, Luirink J.

J Biol Chem. 1999 Oct 15;274(42):29883-8.

16.

Decreasing the chlorophyll a/b ratio in reconstituted LHCII: structural and functional consequences.

Kleima FJ, Hobe S, Calkoen F, Urbanus ML, Peterman EJ, van Grondelle R, Paulsen H, van Amerongen H.

Biochemistry. 1999 May 18;38(20):6587-96.

PMID:
10350477
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