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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1953 2
1954 4
1955 10
1956 4
1957 2
1958 5
1959 3
1960 3
1961 5
1962 5
1963 4
1964 6
1965 2
1967 1
1968 1
1975 3
1977 1
1979 2
1980 9
1981 22
1982 18
1983 7
1984 11
1985 10
1986 15
1987 9
1988 8
1989 6
1990 10
1991 17
1992 35
1993 26
1994 29
1995 43
1996 33
1997 17
1998 20
1999 20
2000 17
2001 13
2002 14
2003 16
2004 13
2005 7
2006 15
2007 18
2008 15
2009 15
2010 11
2011 12
2012 19
2013 25
2014 17
2015 14
2016 15
2017 14
2018 14
2019 12
2020 14
2021 6
2022 10
2023 11
2024 3

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727 results

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Page 1
Tyloxapol inhibits RANKL-stimulated osteoclastogenesis and ovariectomized-induced bone loss by restraining NF-kappaB and MAPK activation.
Guo W, Li H, Lou Y, Zhang Y, Wang J, Qian M, Wei H, Xiao J, Xu Y. Guo W, et al. J Orthop Translat. 2021 Apr 10;28:148-158. doi: 10.1016/j.jot.2021.01.005. eCollection 2021 May. J Orthop Translat. 2021. PMID: 33981577 Free PMC article.
However, the effect of tyloxapol on osteoclastogenesis has not been elucidated. In this study, we intended to clarify the effect of tyloxapol on RANKL-stimulated osteoclastogenesis and the molecular mechanism both ex vivo and in vivo. ...Our study may also extend th …
However, the effect of tyloxapol on osteoclastogenesis has not been elucidated. In this study, we intended to clarify the effect of …
Lipopolysaccharide and tyloxapol accelerate the development of atherosclerosis in mice.
Jin M, Zhang D, Zheng L, Wei Y, Yan S, Qin H, Wang Q, Zhao L, Feng H. Jin M, et al. Lipids. 2022 Mar;57(2):83-90. doi: 10.1002/lipd.12331. Epub 2021 Dec 7. Lipids. 2022. PMID: 34875723
It has been found that lipopolysaccharide (LPS) could induce inflammation, and tyloxapol (Ty) could induce hyperlipidemia. However, the effects of LPS and Ty on the development and mechanism of atherosclerosis have not been investigated thoroughly. ...
It has been found that lipopolysaccharide (LPS) could induce inflammation, and tyloxapol (Ty) could induce hyperlipidemia. However, t …
Cytotoxic properties of tyloxapol.
Kuo JH, Jan MS, Chiu HW. Kuo JH, et al. Pharm Res. 2006 Jul;23(7):1509-16. doi: 10.1007/s11095-006-0281-y. Epub 2006 Jun 21. Pharm Res. 2006. PMID: 16779702
Hence, the objective of this study was to determine whether tyloxapol causes apoptosis or necrosis. These data could be helpful for a better understanding of the action of tyloxapol in cellular systems. ...Tyloxapol treatment damaged RAW 264.7 cells more than …
Hence, the objective of this study was to determine whether tyloxapol causes apoptosis or necrosis. These data could be helpful for a …
Pterostilbene alleviated NAFLD via AMPK/mTOR signaling pathways and autophagy by promoting Nrf2.
Shen B, Wang Y, Cheng J, Peng Y, Zhang Q, Li Z, Zhao L, Deng X, Feng H. Shen B, et al. Phytomedicine. 2023 Jan;109:154561. doi: 10.1016/j.phymed.2022.154561. Epub 2022 Nov 21. Phytomedicine. 2023. PMID: 36610156
PURPOSE: This study provides a mechanism of PTE affecting on oxidative stress and autophagy in NAFLD mice. Tyloxapol, oil acid (OA) and palmitic acid (PA) were used to induce lipid accumulation in mice and HepG2 cells. ...RESULTS: PTE pretreatment effectively reduced the l …
PURPOSE: This study provides a mechanism of PTE affecting on oxidative stress and autophagy in NAFLD mice. Tyloxapol, oil acid (OA) a …
Aucubin inhibited lipid accumulation and oxidative stress via Nrf2/HO-1 and AMPK signalling pathways.
Shen B, Zhao C, Wang Y, Peng Y, Cheng J, Li Z, Wu L, Jin M, Feng H. Shen B, et al. J Cell Mol Med. 2019 Jun;23(6):4063-4075. doi: 10.1111/jcmm.14293. Epub 2019 Apr 4. J Cell Mol Med. 2019. PMID: 30950217 Free PMC article.
Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease. In this research, we explored the effects of AU on the tyloxapol-induced NAFLD in mice and apolipoprotein C-III (apoC-III) induced-3T3L1 cells. Tyloxapol (300 mg/kg) was inj …
Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease. In this research, we explored the effects of AU …
Tyloxapol attenuates the pathologic effects of endotoxin in rabbits and mortality following cecal ligation and puncture in rats by blockade of endotoxin receptor-ligand interactions.
Serikov VB, Glazanova TV, Jerome EH, Fleming NW, Higashimori H, Staub NC Sr. Serikov VB, et al. Inflammation. 2003 Aug;27(4):175-90. doi: 10.1023/a:1025108207661. Inflammation. 2003. PMID: 14527171
We have previously demonstrated that the detergent Tyloxapol is effective in preventing reactions to endotoxin. We studied the effects of Tyloxapol on the morbidity and mortality from endotoxemia in rabbits and on the mortality in rats with sepsis. ...Tyloxapol …
We have previously demonstrated that the detergent Tyloxapol is effective in preventing reactions to endotoxin. We studied the effect …
Geniposide alleviates non-alcohol fatty liver disease via regulating Nrf2/AMPK/mTOR signalling pathways.
Shen B, Feng H, Cheng J, Li Z, Jin M, Zhao L, Wang Q, Qin H, Liu G. Shen B, et al. J Cell Mol Med. 2020 May;24(9):5097-5108. doi: 10.1111/jcmm.15139. Epub 2020 Apr 15. J Cell Mol Med. 2020. PMID: 32293113 Free PMC article.
Geniposide (GEN), a kind of iridoid glycoside extracted from Gardenia jasminoides fruit, has many biological effects, such as resistance to cell damage and anti-neurodegenerative disorder. Lipid accumulation was obvious in tyloxapol-induced liver and oil acid (OA) with pal …
Geniposide (GEN), a kind of iridoid glycoside extracted from Gardenia jasminoides fruit, has many biological effects, such as resistance to …
Tyloxapol niosomes as prospective drug delivery module for antiretroviral drug nevirapine.
Mehta SK, Jindal N. Mehta SK, et al. AAPS PharmSciTech. 2015 Feb;16(1):67-75. doi: 10.1208/s12249-014-0183-y. Epub 2014 Sep 3. AAPS PharmSciTech. 2015. PMID: 25182386 Free PMC article.
Biocompatible niosomes were fabricated using a biological surfactant, tyloxapol, with variable cholesterol concentrations. Formulation with surfactant/cholesterol molar ratio 1:0.1 exhibits maximum stability and optimum hydrophobicity. ...
Biocompatible niosomes were fabricated using a biological surfactant, tyloxapol, with variable cholesterol concentrations. Formulatio …
Digeda-4 decoction and its disassembled prescriptions improve dyslipidemia and apoptosis by regulating AMPK/SIRT1 pathway on tyloxapol-induced nonalcoholic fatty liver disease in mice.
Ji X, Ma Q, Wang X, Ming H, Bao G, Fu M, Wei C. Ji X, et al. J Ethnopharmacol. 2023 Dec 5;317:116827. doi: 10.1016/j.jep.2023.116827. Epub 2023 Jun 20. J Ethnopharmacol. 2023. PMID: 37348794
AIM OF THIS STUDY: To study whether DGD-4 and its disassembled prescriptions have protective effects against tyloxapol (TY)-induced NAFLD and to explore the underlying mechanisms of action and compatibility of prescriptions. ...
AIM OF THIS STUDY: To study whether DGD-4 and its disassembled prescriptions have protective effects against tyloxapol (TY)-induced N …
Mucolytic Effectiveness of Tyloxapol in Chronic Obstructive Pulmonary Disease - A Double-Blind, Randomized Controlled Trial.
Koppitz M, Eschenburg C, Salzmann E, Rosewich M, Schubert R, Zielen S. Koppitz M, et al. PLoS One. 2016 Jun 16;11(6):e0156999. doi: 10.1371/journal.pone.0156999. eCollection 2016. PLoS One. 2016. PMID: 27308826 Free PMC article. Clinical Trial.
The p-value at three weeks of treatment was 0.041 between treatment arms. Sputum cells decreased during the Tyloxapol treatment after 3 weeks, indicating that Tyloxapol might have some anti-neutrophilic properties. ...Eleven patients experienced AEs under Tyloxap …
The p-value at three weeks of treatment was 0.041 between treatment arms. Sputum cells decreased during the Tyloxapol treatment after …
727 results