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Items: 1 to 20 of 279

1.

Inhibition of Dopamine Receptor D4 Impedes Autophagic Flux, Proliferation, and Survival of Glioblastoma Stem Cells.

Dolma S, Selvadurai HJ, Lan X, Lee L, Kushida M, Voisin V, Whetstone H, So M, Aviv T, Park N, Zhu X, Xu C, Head R, Rowland KJ, Bernstein M, Clarke ID, Bader G, Harrington L, Brumell JH, Tyers M, Dirks PB.

Cancer Cell. 2016 Jun 13;29(6):859-73. doi: 10.1016/j.ccell.2016.05.002.

PMID:
27300435
2.

Prediction of Synergism from Chemical-Genetic Interactions by Machine Learning.

Wildenhain J, Spitzer M, Dolma S, Jarvik N, White R, Roy M, Griffiths E, Bellows DS, Wright GD, Tyers M.

Cell Syst. 2015 Dec 23;1(6):383-95. doi: 10.1016/j.cels.2015.12.003. Epub 2015 Dec 23.

PMID:
27136353
3.

Data Independent Acquisition analysis in ProHits 4.0.

Liu G, Knight JD, Zhang JP, Tsou CC, Wang J, Lambert JP, Larsen B, Tyers M, Raught B, Bandeira N, Nesvizhskii AI, Choi H, Gingras AC.

J Proteomics. 2016 Apr 29. pii: S1874-3919(16)30174-9. doi: 10.1016/j.jprot.2016.04.042. [Epub ahead of print]

PMID:
27132685
4.

Inhibition of SCF ubiquitin ligases by engineered ubiquitin variants that target the Cul1 binding site on the Skp1-F-box interface.

Gorelik M, Orlicky S, Sartori MA, Tang X, Marcon E, Kurinov I, Greenblatt JF, Tyers M, Moffat J, Sicheri F, Sidhu SS.

Proc Natl Acad Sci U S A. 2016 Mar 29;113(13):3527-32. doi: 10.1073/pnas.1519389113. Epub 2016 Mar 14.

5.

BioGRID: A Resource for Studying Biological Interactions in Yeast.

Oughtred R, Chatr-aryamontri A, Breitkreutz BJ, Chang CS, Rust JM, Theesfeld CL, Heinicke S, Breitkreutz A, Chen D, Hirschman J, Kolas N, Livstone MS, Nixon J, O'Donnell L, Ramage L, Winter A, Reguly T, Sellam A, Stark C, Boucher L, Dolinski K, Tyers M.

Cold Spring Harb Protoc. 2016 Jan 4;2016(1):pdb.top080754. doi: 10.1101/pdb.top080754.

PMID:
26729913
6.

Use of the BioGRID Database for Analysis of Yeast Protein and Genetic Interactions.

Oughtred R, Chatr-aryamontri A, Breitkreutz BJ, Chang CS, Rust JM, Theesfeld CL, Heinicke S, Breitkreutz A, Chen D, Hirschman J, Kolas N, Livstone MS, Nixon J, O'Donnell L, Ramage L, Winter A, Reguly T, Sellam A, Stark C, Boucher L, Dolinski K, Tyers M.

Cold Spring Harb Protoc. 2016 Jan 4;2016(1):pdb.prot088880. doi: 10.1101/pdb.prot088880.

PMID:
26729909
7.

An Antifungal Combination Matrix Identifies a Rich Pool of Adjuvant Molecules that Enhance Drug Activity against Diverse Fungal Pathogens.

Robbins N, Spitzer M, Yu T, Cerone RP, Averette AK, Bahn YS, Heitman J, Sheppard DC, Tyers M, Wright GD.

Cell Rep. 2015 Nov 17;13(7):1481-92. doi: 10.1016/j.celrep.2015.10.018. Epub 2015 Nov 5.

8.

Caenorhabditis elegans is a useful model for anthelmintic discovery.

Burns AR, Luciani GM, Musso G, Bagg R, Yeo M, Zhang Y, Rajendran L, Glavin J, Hunter R, Redman E, Stasiuk S, Schertzberg M, Angus McQuibban G, Caffrey CR, Cutler SR, Tyers M, Giaever G, Nislow C, Fraser AG, MacRae CA, Gilleard J, Roy PJ.

Nat Commun. 2015 Jun 25;6:7485. doi: 10.1038/ncomms8485.

9.

Sample Collection Method Bias Effects in Quantitative Phosphoproteomics.

Kanshin E, Tyers M, Thibault P.

J Proteome Res. 2015 Jul 2;14(7):2998-3004. doi: 10.1021/acs.jproteome.5b00404. Epub 2015 Jun 16.

PMID:
26040406
10.

Panspecies small-molecule disruptors of heterochromatin-mediated transcriptional gene silencing.

Castonguay E, White SA, Kagansky A, St-Cyr DJ, Castillo AG, Brugger C, White R, Bonilla C, Spitzer M, Earnshaw WC, Schalch T, Ekwall K, Tyers M, Allshire RC.

Mol Cell Biol. 2015 Feb;35(4):662-74. doi: 10.1128/MCB.01102-14. Epub 2014 Dec 8.

11.

The BioGRID interaction database: 2015 update.

Chatr-Aryamontri A, Breitkreutz BJ, Oughtred R, Boucher L, Heinicke S, Chen D, Stark C, Breitkreutz A, Kolas N, O'Donnell L, Reguly T, Nixon J, Ramage L, Winter A, Sellam A, Chang C, Hirschman J, Theesfeld C, Rust J, Livstone MS, Dolinski K, Tyers M.

Nucleic Acids Res. 2015 Jan;43(Database issue):D470-8. doi: 10.1093/nar/gku1204. Epub 2014 Nov 26.

12.

Targeting the INCENP IN-box-Aurora B interaction to inhibit CPC activity in vivo.

Gohard FH, St-Cyr DJ, Tyers M, Earnshaw WC.

Open Biol. 2014 Nov;4(11):140163. doi: 10.1098/rsob.140163.

13.

Structural basis for the recruitment of glycogen synthase by glycogenin.

Zeqiraj E, Tang X, Hunter RW, GarcĂ­a-Rocha M, Judd A, Deak M, von Wilamowitz-Moellendorff A, Kurinov I, Guinovart JJ, Tyers M, Sakamoto K, Sicheri F.

Proc Natl Acad Sci U S A. 2014 Jul 15;111(28):E2831-40. doi: 10.1073/pnas.1402926111. Epub 2014 Jun 30.

14.

A loss of function analysis of host factors influencing Vaccinia virus replication by RNA interference.

Beard PM, Griffiths SJ, Gonzalez O, Haga IR, Pechenick Jowers T, Reynolds DK, Wildenhain J, Tekotte H, Auer M, Tyers M, Ghazal P, Zimmer R, Haas J.

PLoS One. 2014 Jun 5;9(6):e98431. doi: 10.1371/journal.pone.0098431. eCollection 2014.

15.

Regulation of the histone deacetylase Hst3 by cyclin-dependent kinases and the ubiquitin ligase SCFCdc4.

Delgoshaie N, Tang X, Kanshin ED, Williams EC, Rudner AD, Thibault P, Tyers M, Verreault A.

J Biol Chem. 2014 May 9;289(19):13186-96. doi: 10.1074/jbc.M113.523530. Epub 2014 Mar 19.

16.

BoxPlotR: a web tool for generation of box plots.

Spitzer M, Wildenhain J, Rappsilber J, Tyers M.

Nat Methods. 2014 Feb;11(2):121-2. doi: 10.1038/nmeth.2811. No abstract available.

17.

E2 enzyme inhibition by stabilization of a low-affinity interface with ubiquitin.

Huang H, Ceccarelli DF, Orlicky S, St-Cyr DJ, Ziemba A, Garg P, Plamondon S, Auer M, Sidhu S, Marinier A, Kleiger G, Tyers M, Sicheri F.

Nat Chem Biol. 2014 Feb;10(2):156-63. doi: 10.1038/nchembio.1412. Epub 2013 Dec 15.

18.

Structure of an SspH1-PKN1 complex reveals the basis for host substrate recognition and mechanism of activation for a bacterial E3 ubiquitin ligase.

Keszei AF, Tang X, McCormick C, Zeqiraj E, Rohde JR, Tyers M, Sicheri F.

Mol Cell Biol. 2014 Feb;34(3):362-73. doi: 10.1128/MCB.01360-13. Epub 2013 Nov 18.

19.

The PhosphoGRID Saccharomyces cerevisiae protein phosphorylation site database: version 2.0 update.

Sadowski I, Breitkreutz BJ, Stark C, Su TC, Dahabieh M, Raithatha S, Bernhard W, Oughtred R, Dolinski K, Barreto K, Tyers M.

Database (Oxford). 2013 May 13;2013:bat026. doi: 10.1093/database/bat026. Print 2013.

20.

Systematic curation of protein and genetic interaction data for computable biology.

Dolinski K, Chatr-Aryamontri A, Tyers M.

BMC Biol. 2013 Apr 15;11:43. doi: 10.1186/1741-7007-11-43. Review. No abstract available.

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