New methyl 5-(halomethyl)-1-aryl-1H-1,2,4-triazole-3-carboxylates as selective COX-2 inhibitors and anti-inflammatory agents: Design, synthesis, biological evaluation, and docking study.
Li SM, Tsai SE, Chiang CY, Chung CY, Chuang TJ, Tseng CC, Jiang WP, Huang GJ, Lin CY, Yang YC, Fuh MT, Wong FF.
Li SM, et al.
Bioorg Chem. 2020 Nov;104:104333. doi: 10.1016/j.bioorg.2020.104333. Epub 2020 Oct 2.
Bioorg Chem. 2020.
PMID: 33142408
Furthermore, 5 mg/kg compound 5d exhibited better in vivo anti-inflammation and gastric protection results compared to 10 mg/kg Indomethacin. Docking experiments of 5d into COX-2 binding pocket have been evaluated. Following the bioactivities experimental data, the …
Furthermore, 5 mg/kg compound 5d exhibited better in vivo anti-inflammation and gastric protection results compared to 10 mg/kg Indom …