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Prion strains and amyloid polymorphism influence phenotypic variation.

Stein KC, True HL.

PLoS Pathog. 2014 Sep 4;10(9):e1004328. doi: 10.1371/journal.ppat.1004328. eCollection 2014 Sep. No abstract available.


Structural variants of yeast prions show conformer-specific requirements for chaperone activity.

Stein KC, True HL.

Mol Microbiol. 2014 Sep;93(6):1156-71. doi: 10.1111/mmi.12725. Epub 2014 Aug 21.


Myopathy-causing mutations in an HSP40 chaperone disrupt processing of specific client conformers.

Stein KC, Bengoechea R, Harms MB, Weihl CC, True HL.

J Biol Chem. 2014 Jul 25;289(30):21120-30.


Extensive diversity of prion strains is defined by differential chaperone interactions and distinct amyloidogenic regions.

Stein KC, True HL.

PLoS Genet. 2014 May 8;10(5):e1004337. doi: 10.1371/journal.pgen.1004337. eCollection 2014 May.


Wild yeast harbour a variety of distinct amyloid structures with strong prion-inducing capabilities.

Westergard L, True HL.

Mol Microbiol. 2014 Apr;92(1):183-93. doi: 10.1111/mmi.12543. Epub 2014 Mar 7.


Extracellular environment modulates the formation and propagation of particular amyloid structures.

Westergard L, True HL.

Mol Microbiol. 2014 May;92(4):698-715. doi: 10.1111/mmi.12579. Epub 2014 Apr 9.


Regulation of the Hsp104 middle domain activity is critical for yeast prion propagation.

Dulle JE, Stein KC, True HL.

PLoS One. 2014 Jan 23;9(1):e87521. doi: 10.1371/journal.pone.0087521. eCollection 2014.


Spontaneous variants of the [RNQ+] prion in yeast demonstrate the extensive conformational diversity possible with prion proteins.

Huang VJ, Stein KC, True HL.

PLoS One. 2013 Oct 25;8(10):e79582. doi: 10.1371/journal.pone.0079582. eCollection 2013.


Soluble oligomers are sufficient for transmission of a yeast prion but do not confer phenotype.

Dulle JE, Bouttenot RE, Underwood LA, True HL.

J Cell Biol. 2013 Oct 28;203(2):197-204. doi: 10.1083/jcb.201307040. Epub 2013 Oct 21.


Low activity of select Hsp104 mutants is sufficient to propagate unstable prion variants.

Dulle JE, True HL.

Prion. 2013 Sep-Oct;7(5):394-403. doi: 10.4161/pri.26547. Epub 2013 Sep 24.


Prion-like nuclear aggregation of TDP-43 during heat shock is regulated by HSP40/70 chaperones.

Udan-Johns M, Bengoechea R, Bell S, Shao J, Diamond MI, True HL, Weihl CC, Baloh RH.

Hum Mol Genet. 2014 Jan 1;23(1):157-70. doi: 10.1093/hmg/ddt408. Epub 2013 Aug 19.


The [RNQ+] prion: a model of both functional and pathological amyloid.

Stein KC, True HL.

Prion. 2011 Oct-Dec;5(4):291-8. doi: 10.4161/pri.18213. Epub 2011 Oct 1. Review.


Analysis of the [RNQ+] prion reveals stability of amyloid fibers as the key determinant of yeast prion variant propagation.

Kalastavadi T, True HL.

J Biol Chem. 2010 Jul 2;285(27):20748-55. doi: 10.1074/jbc.M110.115303. Epub 2010 May 4.


The spontaneous appearance rate of the yeast prion [PSI+] and its implications for the evolution of the evolvability properties of the [PSI+] system.

Lancaster AK, Bardill JP, True HL, Masel J.

Genetics. 2010 Feb;184(2):393-400. doi: 10.1534/genetics.109.110213. Epub 2009 Nov 16.


The Sua5 protein is essential for normal translational regulation in yeast.

Lin CA, Ellis SR, True HL.

Mol Cell Biol. 2010 Jan;30(1):354-63. doi: 10.1128/MCB.00754-09. Epub .


Requirements of Hsp104p activity and Sis1p binding for propagation of the [RNQ(+)] prion.

Bardill JP, Dulle JE, Fisher JR, True HL.

Prion. 2009 Jul-Sep;3(3):151-60. Epub 2009 Jul 30.


Heterologous prion interactions are altered by mutations in the prion protein Rnq1p.

Bardill JP, True HL.

J Mol Biol. 2009 May 8;388(3):583-96. doi: 10.1016/j.jmb.2009.03.036. Epub 2009 Mar 24.


Mutants of the Paf1 complex alter phenotypic expression of the yeast prion [PSI+].

Strawn LA, Lin CA, Tank EM, Osman MM, Simpson SA, True HL.

Mol Biol Cell. 2009 Apr;20(8):2229-41. doi: 10.1091/mbc.E08-08-0813. Epub 2009 Feb 18.


Disease-associated mutant ubiquitin causes proteasomal impairment and enhances the toxicity of protein aggregates.

Tank EM, True HL.

PLoS Genet. 2009 Feb;5(2):e1000382. doi: 10.1371/journal.pgen.1000382. Epub 2009 Feb 13.


Insights into intragenic and extragenic effectors of prion propagation using chimeric prion proteins.

True HL, Kalastavadi T, Tank EM.

Prion. 2008 Apr-Jun;2(2):45-7. Epub 2008 Apr 17. Review.

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