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Results: 1 to 20 of 239

1.

A natural genetic variant of granzyme B confers lethality to a common viral infection.

Andoniou CE, Sutton VR, Wikstrom ME, Fleming P, Thia KY, Matthews AY, Kaiserman D, Schuster IS, Coudert JD, Eldi P, Chaudhri G, Karupiah G, Bird PI, Trapani JA, Degli-Esposti MA.

PLoS Pathog. 2014 Dec 11;10(12):e1004526. doi: 10.1371/journal.ppat.1004526. eCollection 2014 Dec.

PMID:
25502180
[PubMed - in process]
Free PMC Article
2.

A colorimetric assay that specifically measures Granzyme B proteolytic activity: hydrolysis of Boc-Ala-Ala-Asp-S-Bzl.

Hagn M, Sutton VR, Trapani JA.

J Vis Exp. 2014 Nov 28;(93):e52419. doi: 10.3791/52419.

PMID:
25489668
[PubMed - in process]
3.

A Radio-Resistant Perforin-Expressing Lymphoid Population Controls Allogeneic T Cell Engraftment, Activation, and Onset of Graft-versus-Host Disease in Mice.

Davis JE, Harvey M, Gherardin NA, Koldej R, Huntington N, Neeson P, Trapani JA, Ritchie DS.

Biol Blood Marrow Transplant. 2015 Feb;21(2):242-9. doi: 10.1016/j.bbmt.2014.11.003. Epub 2014 Nov 12.

PMID:
25459639
[PubMed - in process]
4.

TRAIL+ NK cells control CD4+ T cell responses during chronic viral infection to limit autoimmunity.

Schuster IS, Wikstrom ME, Brizard G, Coudert JD, Estcourt MJ, Manzur M, O'Reilly LA, Smyth MJ, Trapani JA, Hill GR, Andoniou CE, Degli-Esposti MA.

Immunity. 2014 Oct 16;41(4):646-56. doi: 10.1016/j.immuni.2014.09.013.

PMID:
25367576
[PubMed - indexed for MEDLINE]
5.

A method for detecting intracellular perforin in mouse lymphocytes.

Brennan AJ, House IG, Oliaro J, Ramsbottom KM, Hagn M, Yagita H, Trapani JA, Voskoboinik I.

J Immunol. 2014 Dec 1;193(11):5744-50. doi: 10.4049/jimmunol.1402207. Epub 2014 Oct 27.

PMID:
25348626
[PubMed - in process]
6.

Granzyme H is a novel protease expressed by human mast cells.

Rönnberg E, Calounova G, Sutton VR, Trapani JA, Rollman O, Hagforsen E, Pejler G.

Int Arch Allergy Immunol. 2014;165(1):68-74. doi: 10.1159/000368403. Epub 2014 Oct 21.

PMID:
25342632
[PubMed - in process]
7.

The preclinical pharmacokinetic disposition of a series of perforin-inhibitors as potential immunosuppressive agents.

Bull MR, Spicer JA, Huttunen KM, Denny WA, Ciccone A, Browne KA, Trapani JA, Helsby NA.

Eur J Drug Metab Pharmacokinet. 2014 Aug 26. [Epub ahead of print]

PMID:
25155444
[PubMed - as supplied by publisher]
8.

Familial haemophagocytic lymphohistiocytosis: Australian experience and perspectives.

Voskoboinik I, Thia K, Trapani JA.

Intern Med J. 2014 Aug;44(8):826-7. doi: 10.1111/imj.12493. No abstract available.

PMID:
25081055
[PubMed - in process]
9.

NK cell intrinsic regulation of MIP-1α by granzyme M.

Baschuk N, Wang N, Watt SV, Halse H, House C, Bird PI, Strugnell R, Trapani JA, Smyth MJ, Andrews DM.

Cell Death Dis. 2014 Mar 13;5:e1115. doi: 10.1038/cddis.2014.74.

PMID:
24625974
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

The perforin pore facilitates the delivery of cationic cargos.

Stewart SE, Kondos SC, Matthews AY, D'Angelo ME, Dunstone MA, Whisstock JC, Trapani JA, Bird PI.

J Biol Chem. 2014 Mar 28;289(13):9172-81. doi: 10.1074/jbc.M113.544890. Epub 2014 Feb 20.

PMID:
24558045
[PubMed - indexed for MEDLINE]
11.

B-CLL cells acquire APC- and CTL-like phenotypic characteristics after stimulation with CpG ODN and IL-21.

Hagn M, Blackwell SE, Beyer T, Ebel V, Fabricius D, Lindner S, Stilgenbauer S, Simmet T, Tam C, Neeson P, Trapani JA, Schrezenmeier H, Weiner GJ, Jahrsdörfer B.

Int Immunol. 2014 Jul;26(7):383-95. doi: 10.1093/intimm/dxu001. Epub 2014 Feb 4.

PMID:
24497611
[PubMed - in process]
12.

A functional genomics screen identifies PCAF and ADA3 as regulators of human granzyme B-mediated apoptosis and Bid cleavage.

Brasacchio D, Noori T, House C, Brennan AJ, Simpson KJ, Susanto O, Bird PI, Johnstone RW, Trapani JA.

Cell Death Differ. 2014 May;21(5):748-60. doi: 10.1038/cdd.2013.203. Epub 2014 Jan 24.

PMID:
24464226
[PubMed - indexed for MEDLINE]
13.

Perforinopathy: a spectrum of human immune disease caused by defective perforin delivery or function.

Voskoboinik I, Trapani JA.

Front Immunol. 2013 Dec 12;4:441. doi: 10.3389/fimmu.2013.00441. Review.

PMID:
24376445
[PubMed]
Free PMC Article
14.

Exploration of a series of 5-arylidene-2-thioxoimidazolidin-4-ones as inhibitors of the cytolytic protein perforin.

Spicer JA, Lena G, Lyons DM, Huttunen KM, Miller CK, O'Connor PD, Bull M, Helsby N, Jamieson SM, Denny WA, Ciccone A, Browne KA, Lopez JA, Rudd-Schmidt J, Voskoboinik I, Trapani JA.

J Med Chem. 2013 Dec 12;56(23):9542-55. doi: 10.1021/jm401604x. Epub 2013 Nov 19.

PMID:
24195776
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Defining the interaction of perforin with calcium and the phospholipid membrane.

Traore DA, Brennan AJ, Law RH, Dogovski C, Perugini MA, Lukoyanova N, Leung EW, Norton RS, Lopez JA, Browne KA, Yagita H, Lloyd GJ, Ciccone A, Verschoor S, Trapani JA, Whisstock JC, Voskoboinik I.

Biochem J. 2013 Dec 15;456(3):323-35. doi: 10.1042/BJ20130999.

PMID:
24070258
[PubMed - in process]
Free Article
16.

Rapid and unidirectional perforin pore delivery at the cytotoxic immune synapse.

Lopez JA, Jenkins MR, Rudd-Schmidt JA, Brennan AJ, Danne JC, Mannering SI, Trapani JA, Voskoboinik I.

J Immunol. 2013 Sep 1;191(5):2328-34. doi: 10.4049/jimmunol.1301205. Epub 2013 Jul 24.

PMID:
23885110
[PubMed - indexed for MEDLINE]
Free Article
17.

Persistence and efficacy of second generation CAR T cell against the LeY antigen in acute myeloid leukemia.

Ritchie DS, Neeson PJ, Khot A, Peinert S, Tai T, Tainton K, Chen K, Shin M, Wall DM, Hönemann D, Gambell P, Westerman DA, Haurat J, Westwood JA, Scott AM, Kravets L, Dickinson M, Trapani JA, Smyth MJ, Darcy PK, Kershaw MH, Prince HM.

Mol Ther. 2013 Nov;21(11):2122-9. doi: 10.1038/mt.2013.154. Epub 2013 Jul 8.

PMID:
23831595
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Mouse granzyme A induces a novel death with writhing morphology that is mechanistically distinct from granzyme B-induced apoptosis.

Susanto O, Stewart SE, Voskoboinik I, Brasacchio D, Hagn M, Ellis S, Asquith S, Sedelies KA, Bird PI, Waterhouse NJ, Trapani JA.

Cell Death Differ. 2013 Sep;20(9):1183-93. doi: 10.1038/cdd.2013.59. Epub 2013 Jun 7.

PMID:
23744295
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Human perforin mutations and susceptibility to multiple primary cancers.

Trapani JA, Thia KY, Andrews M, Davis ID, Gedye C, Parente P, Svobodova S, Chia J, Browne K, Campbell IG, Phillips WA, Voskoboinik I, Cebon JS.

Oncoimmunology. 2013 Apr 1;2(4):e24185.

PMID:
23734337
[PubMed]
Free PMC Article
20.

Cloning and characterising an unusual perforin from chicken (Gallus gallus).

D'Angelo ME, Arjomand A, Trapani JA, Bird PI.

Dev Comp Immunol. 2013 Oct;41(2):105-9. doi: 10.1016/j.dci.2013.05.003. Epub 2013 May 13.

PMID:
23680640
[PubMed - indexed for MEDLINE]
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