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Results: 1 to 20 of 231

1.

NK cell intrinsic regulation of MIP-1α by granzyme M.

Baschuk N, Wang N, Watt SV, Halse H, House C, Bird PI, Strugnell R, Trapani JA, Smyth MJ, Andrews DM.

Cell Death Dis. 2014 Mar 13;5:e1115. doi: 10.1038/cddis.2014.74.

PMID:
24625974
[PubMed - in process]
Free PMC Article
2.

The perforin pore facilitates the delivery of cationic cargos.

Stewart SE, Kondos SC, Matthews AY, D'Angelo ME, Dunstone MA, Whisstock JC, Trapani JA, Bird PI.

J Biol Chem. 2014 Mar 28;289(13):9172-81. doi: 10.1074/jbc.M113.544890. Epub 2014 Feb 20.

PMID:
24558045
[PubMed - indexed for MEDLINE]
3.

B-CLL cells acquire APC- and CTL-like phenotypic characteristics after stimulation with CpG ODN and IL-21.

Hagn M, Blackwell SE, Beyer T, Ebel V, Fabricius D, Lindner S, Stilgenbauer S, Simmet T, Tam C, Neeson P, Trapani JA, Schrezenmeier H, Weiner GJ, Jahrsdörfer B.

Int Immunol. 2014 Jul;26(7):383-95. doi: 10.1093/intimm/dxu001. Epub 2014 Feb 4.

PMID:
24497611
[PubMed - in process]
4.

A functional genomics screen identifies PCAF and ADA3 as regulators of human granzyme B-mediated apoptosis and Bid cleavage.

Brasacchio D, Noori T, House C, Brennan AJ, Simpson KJ, Susanto O, Bird PI, Johnstone RW, Trapani JA.

Cell Death Differ. 2014 May;21(5):748-60. doi: 10.1038/cdd.2013.203. Epub 2014 Jan 24.

PMID:
24464226
[PubMed - in process]
5.

Perforinopathy: a spectrum of human immune disease caused by defective perforin delivery or function.

Voskoboinik I, Trapani JA.

Front Immunol. 2013 Dec 12;4:441. doi: 10.3389/fimmu.2013.00441. Review.

PMID:
24376445
[PubMed]
Free PMC Article
6.

Exploration of a series of 5-arylidene-2-thioxoimidazolidin-4-ones as inhibitors of the cytolytic protein perforin.

Spicer JA, Lena G, Lyons DM, Huttunen KM, Miller CK, O'Connor PD, Bull M, Helsby N, Jamieson SM, Denny WA, Ciccone A, Browne KA, Lopez JA, Rudd-Schmidt J, Voskoboinik I, Trapani JA.

J Med Chem. 2013 Dec 12;56(23):9542-55. doi: 10.1021/jm401604x. Epub 2013 Nov 19.

PMID:
24195776
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Defining the interaction of perforin with calcium and the phospholipid membrane.

Traore DA, Brennan AJ, Law RH, Dogovski C, Perugini MA, Lukoyanova N, Leung EW, Norton RS, Lopez JA, Browne KA, Yagita H, Lloyd GJ, Ciccone A, Verschoor S, Trapani JA, Whisstock JC, Voskoboinik I.

Biochem J. 2013 Dec 15;456(3):323-35. doi: 10.1042/BJ20130999.

PMID:
24070258
[PubMed - in process]
8.

Rapid and unidirectional perforin pore delivery at the cytotoxic immune synapse.

Lopez JA, Jenkins MR, Rudd-Schmidt JA, Brennan AJ, Danne JC, Mannering SI, Trapani JA, Voskoboinik I.

J Immunol. 2013 Sep 1;191(5):2328-34. doi: 10.4049/jimmunol.1301205. Epub 2013 Jul 24.

PMID:
23885110
[PubMed - indexed for MEDLINE]
9.

Persistence and efficacy of second generation CAR T cell against the LeY antigen in acute myeloid leukemia.

Ritchie DS, Neeson PJ, Khot A, Peinert S, Tai T, Tainton K, Chen K, Shin M, Wall DM, Hönemann D, Gambell P, Westerman DA, Haurat J, Westwood JA, Scott AM, Kravets L, Dickinson M, Trapani JA, Smyth MJ, Darcy PK, Kershaw MH, Prince HM.

Mol Ther. 2013 Nov;21(11):2122-9. doi: 10.1038/mt.2013.154. Epub 2013 Jul 8.

PMID:
23831595
[PubMed - indexed for MEDLINE]
10.

Mouse granzyme A induces a novel death with writhing morphology that is mechanistically distinct from granzyme B-induced apoptosis.

Susanto O, Stewart SE, Voskoboinik I, Brasacchio D, Hagn M, Ellis S, Asquith S, Sedelies KA, Bird PI, Waterhouse NJ, Trapani JA.

Cell Death Differ. 2013 Sep;20(9):1183-93. doi: 10.1038/cdd.2013.59. Epub 2013 Jun 7.

PMID:
23744295
[PubMed - indexed for MEDLINE]
11.

Human perforin mutations and susceptibility to multiple primary cancers.

Trapani JA, Thia KY, Andrews M, Davis ID, Gedye C, Parente P, Svobodova S, Chia J, Browne K, Campbell IG, Phillips WA, Voskoboinik I, Cebon JS.

Oncoimmunology. 2013 Apr 1;2(4):e24185.

PMID:
23734337
[PubMed]
Free PMC Article
12.

Cloning and characterising an unusual perforin from chicken (Gallus gallus).

D'Angelo ME, Arjomand A, Trapani JA, Bird PI.

Dev Comp Immunol. 2013 Oct;41(2):105-9. doi: 10.1016/j.dci.2013.05.003. Epub 2013 May 13.

PMID:
23680640
[PubMed - indexed for MEDLINE]
13.

Perforin forms transient pores on the target cell plasma membrane to facilitate rapid access of granzymes during killer cell attack.

Lopez JA, Susanto O, Jenkins MR, Lukoyanova N, Sutton VR, Law RH, Johnston A, Bird CH, Bird PI, Whisstock JC, Trapani JA, Saibil HR, Voskoboinik I.

Blood. 2013 Apr 4;121(14):2659-68. doi: 10.1182/blood-2012-07-446146. Epub 2013 Feb 1.

PMID:
23377437
[PubMed - indexed for MEDLINE]
Free Article
14.

Surprisingly variable "dangers, toils, and snares" faced by humans and mice.

Trapani JA, Voskoboinik I.

Blood. 2013 Jan 24;121(4):568-70. doi: 10.1182/blood-2012-11-468652. No abstract available.

PMID:
23349371
[PubMed - indexed for MEDLINE]
Free Article
15.

Controversies in granzyme biology.

Susanto O, Trapani JA, Brasacchio D.

Tissue Antigens. 2012 Dec;80(6):477-87. doi: 10.1111/tan.12014. Review.

PMID:
23137319
[PubMed - indexed for MEDLINE]
16.

Granzyme B is dispensable in the development of diabetes in non-obese diabetic mice.

Mollah ZU, Graham KL, Krishnamurthy B, Trivedi P, Brodnicki TC, Trapani JA, Kay TW, Thomas HE.

PLoS One. 2012;7(7):e40357. doi: 10.1371/journal.pone.0040357. Epub 2012 Jul 9.

PMID:
22792290
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Granzyme B triggers a prolonged pressure to die in Bcl-2 overexpressing cells, defining a window of opportunity for effective treatment with ABT-737.

Sutton VR, Sedelies K, Dewson G, Christensen ME, Bird PI, Johnstone RW, Kluck RM, Trapani JA, Waterhouse NJ.

Cell Death Dis. 2012 Jul 5;3:e344. doi: 10.1038/cddis.2012.73.

PMID:
22764103
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

A novel role for granzymes in anti-tumor immunity.

Hoves S, Sutton VR, Trapani JA.

Oncoimmunology. 2012 Mar 1;1(2):219-221.

PMID:
22720248
[PubMed]
Free PMC Article
19.

Protecting a serial killer: pathways for perforin trafficking and self-defence ensure sequential target cell death.

Lopez JA, Brennan AJ, Whisstock JC, Voskoboinik I, Trapani JA.

Trends Immunol. 2012 Aug;33(8):406-12. doi: 10.1016/j.it.2012.04.001. Epub 2012 May 18. Review.

PMID:
22608996
[PubMed - indexed for MEDLINE]
20.

Perforin evolved from a gene duplication of MPEG1, followed by a complex pattern of gene gain and loss within Euteleostomi.

D'Angelo ME, Dunstone MA, Whisstock JC, Trapani JA, Bird PI.

BMC Evol Biol. 2012 May 2;12:59. doi: 10.1186/1471-2148-12-59.

PMID:
22551122
[PubMed - indexed for MEDLINE]
Free PMC Article

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