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Diabetologia. 2012 Jan;55(1):36-45. doi: 10.1007/s00125-011-2357-4. Epub 2011 Oct 29.

Design, history and results of the Thiazolidinedione Intervention with vitamin D Evaluation (TIDE) randomised controlled trial.

Collaborators (715)

Gerstein H, Yusuf S, Avezum A, Birkeland K, Budaj A, Cardona E, Chaithiraphan S, Chan J, Chazova I, Chen J, Cobitz A, Conget I, Dagenais G, Dans A, Diaz R, Dineen S, Hancu N, Hanefeld M, Heller S, Hildebrandt P, Holman R, Jansky P, Lanas F, Leiter L, Lopez-Jaramillo P, Maggioni A, Malaga G, Masud F, Mellbin L, Metelko Z, Murphy K, Niskanen L, O'Donnell M, Pan CY, Parkhomenko A, Pirags V, Probstfield J, Punthakee Z, Ramachandran A, Raptis S, Raslova K, Raubenheimer P, Riddle M, Ryden L, Stoel I, Tankova T, Yusoff K, Zinman B, Gerstein H, Yusuf S, Bosch J, Cobitz A, Dagenais G, Diaz R, Holman R, Murphy K, Probstfield J, Punthakee Z, Ramachandran A, Riddle M, Ryden L, Zinman B, Dagenais G, McKelvie R, Anderson N, Pfeffer M, Bennett P, Chaturvedi N, DeMets D, McMurray J, Diaz R, Alvarisqueta A, Calella P, Frechtel G, Ibanez J, Litvak Bruno M, Lorenzati C, Masjoan F, Medina I, Aizenberg D, Amuchastegui M, Bartolacci I, Bustamante Labarta G, Bustamante Labarta M, Caccavo A, Cantero M, Cardona M, Caruso O, Cozzi Palma M, Cuneo C, De la Pertoza SB, Faingold M, Fernandez R, Fretes J, Garcia Duran R, Garrido M, Giovanelli J, Gomez Vilamajo O, Grinfeld D, Hrabar A, Iglesias R, Killinger C, Kuschnir E, Lagrutta M, Lembo L, Liniado G, Luciardi H, Luquez H, Macin S, Maffei L, Marcucci M, Marino J, Massari M, Mociulsky J, Pachetti M, Piskorz D, Rodriguez M, Rodriguez M, Rodriguez Papini N, Romera M, Ronderos R, Sanchez A, Santos D, Schygiel P, Selzberg S, Sposetti G, Tirado G, Vico M, Vogel D, Wehbe L, Zaidman C, Zucchiatti N, Avezum A, Avezum Oliveira L, Precoma D, Calsolari Pereira de Souza M, Cardoso J, Chacra A, Ribeiro de Oliveira R, Abrantes M, Eliaschewitz F, Fernandes Manenti E, Ferreira dos Santos R, Ferreira Rossi P, Franco R, Gross J, Hernandes M, Leo Wajchenberg B, Matos A, Mendonça Hilgemberg S, Portes E, Rabelo Alves A Jr, Rassi N, Sgarbi J, Zanella M, Tankova T, Zaharieva S, Dagenais G, Leiter L, Abdel-Salam S, Anand S, Aronson R, Belanger A, Berlingieri J, Bhesania T, Cha J, Chiasson J, Goldenberg R, Gottesman I, Gupta G, Hramiak I, Joyce J, Kader T, Kelly A, Liutkus J, Lochnan H, Lonn E, Magloire P, Mehta P, Milot A, Perron P, Poirier P, Rabasa-Lhoret R, Ransom R, Rioux L, Rizvi Q, Ross S, Saunders K, Sigal R, Sohal P, St-Hilaire R, Talbot P, Tan K, Ur E, Weisnagel J, Woo W, Lanas F, Aburto M, Acevedo M, Albornoz F, Balboa W, Cobos J, Potthoff S, Saavedra V, Lopez-Jaramillo P, Accini J, Arcos Palma E, Aroca Martinez G, Botero R, Bruges Ruiz J, Casanova M, Garcia L, Garcia Lozada H, Hernandez E, Higuera Cobos J, Ibarra Gomez J, Jaramillo Gomez N, Luengas C, Manzur F, Molina D, Moreno Salgado G, Orozco A, Perez M, Pertuz Pinzon A, Quintero A, Quiroz R, Sanchez Vallejo G, Sotomayor A, Terront A, Metelko Z, Balen M, Bozikov V, Dubrava D, Erzen D, Goldoni V, Kokić S, Magas S, Maric A, Rubes J, Slosic Weiss S, Sunic E, Tarie D, Tesanovic S, Varzic S, Jansky P, Cech V, Hudcovic M, Jansky P, Jerabek O, Kvapil M, Mandakova E, Oznerova M, Pederzoliova E, Zidkova E, Hildebrandt P, Clemmensen K, Faber J, Helleberg K, Roder M, Svendsen O, Torp-Pedersen C, Urhammer S, Wiggers H, Lopez-Jaramillo P, Duarte Vera Y, Lopez de Felix M, McDermont J, Pasquel Andrade M, Penaherrera E, Niskanen L, Kuusela M, Strand J, Valle T, Hanefeld M, Abdel-Qadar M, Barth D, Bergthold B, Boehm M, Buschmann U, Dietlein M, Donaubauer B, Eckermann T, Elsen A, Forck-Bodeker K, Forst T, Förster A, Frahm E, Frick H, Funke K, Germann H, Grosskopf J, Hagenow A, Hampel T, Hartard M, Himpel A, Huppertz W, Jacob S, Jung T, Klein C, Kleinecke-Pohl U, Kosch C, Krause K, Kusters D, Lahne U, Langenbrink A, Mockesch B, Neuman G, Nischik R, Pohl W, Purr J, Radke R, Regner S, Samer H, Sauter J, Schaefer T, Schaefer A, Schaper F, Schenkenberger I, Schlichthaar H, Schulze E, Schumacher M, Stuchlik G, Tschoepe D, Ulbrich C, Voigt J, Weber H, Weyland K, Wilhelm K, Wilhelm K, Wubbolding H, Zuchner D, Raptis S, Alexandridis T, Boutati E, Elisaf M, Melidonis A, Pappas S, Tentolouris N, Chan J, Lee S, Ozaki R, Tsang C, Yeung F, Ramachandran A, Aravind S, Babu P, Badgandi M, Bantwal G, Bosco B, Chandratreya S, Chandwani P, Deshmukh V, Deshpande N, Dharmalingam M, Gumpeny S, Iska A, Jain S, Joseph S, Kale S, Kalra S, Kannampilly J, Kumar H, Kumar PV, Kumar V, Kumar H, Kumar Sethi B, Muddana A, Murthy S, Nallaperumal S, Pendsey S, Rais N, Ramu Y, Ratnam V, Samad T, Sawhney J, Shah P, Shah D, Sharda A, Sharma V, Tandon N, Dinneen S, O'Donnell M, Sreenan S, Maggioni A, Benemio G, Carbonieri E, Corsi A, De Cosmo S, Donatelli F, Fanelli R, Foglini P, Frisinghelli A, Galluzzo A, Giorda C, Lauro D, Lembo G, Metra M, Moretti L, Piatti P, Reboldi G, Pirags V, Andersone I, Eglite A, Jegere B, Konrade I, Lagzdina I, Leitane I, Olte V, Pastare S, Pirags V, Rezgale I, Sokolova J, Stalte V, Stura I, Teterovska D, Vizina B, Yusoff K, Hussein Z, Mohamed M, Ramanathan L, Tan T, Cardona E, Alvarado R, Arenas Leon J, Bayram Llamas E, Calvo C, Cardona Muñoz E, Cervantes Escarcega J, De la Peña-Toete G, Flota L, Gonzalez J, Gonzalez Guerra J, Guerra-Lopez A, Ledesma Velasco M, Lopez Alvarado A, Marquez E, Parcero Valdes J, Pascoe González S, Saldate-Alonso M, Velasco Sánchez R, Vidrio-Velazquez M, Violante Ortiz R, Stoel I, Den Hartog F, Kragten J, Kuijper A, Lok D, Nierop P, Birkeland K, Istad H, Karlsson T, Langdalen O, Langslet G, Norheim P, Risberg K, Sordal T, Traasdahl L, Masud F, Bilal A, Hashmi Z, Jabbar A, Raza A, Raza H, Zafar J, Malaga G, Barreda L, Burga J, Garcia F, Goya M, Leon L, Manrique H, Marquina P, Paz-Ibarra J, Pinto M, Villena L, Dans A, Edmilao M, Jimeno C, Morales-Palomares E, Nicodemus N, Paz-Pacheco E, Rogelio G, Roxas-Timonera M, Sevilla R, Sulit D, Budaj A, Bronisz M, Czerski T, Franek E, Galaj A, Gniot J, Kopaczewski J, Lysek R, Miekus P, Napora P, Ogorek M, Piepiorka M, Prochaczek F, Racewicz A, Romanczuk P, Szpajer M, Hancu N, Avram RI, Barbonta D, Candrea E, Catrinoiu D, Constantinescu S, Dobjanschi C, Ferariu I, Ghise G, Mota M, Nafornita V, Nicolau A, Onaca A, Pintilei E, Pop L, Popa A, Szilagyi I, Tutescu A, Veresiu I, Chazova I, Ageev F, Akhunova S, Ametov A, Ballyuzek M, Barbarash O, Belkov S, Berstein L, Boyarkin M, Boytsov S, Chazova I, Chumakova G, Dreval A, Ershova O, Esip V, Fitilev S, Galyavich A, Giorgadze M, Goloshchekin B, Gordeev I, Goryachkin I, Ipatko I, Karpov Y, Khasanov N, Kislyak O, Koshelskaya O, Kosmacheva E, Kostenko V, Kostin V, Krivolapova T, Leonova N, Lopatin Y, Lysenko T, Milovanova T, Morozova A, Motylev I, Myasoedova S, Osipova I, Paltsman Z, Panov A, Reshedko G, Rodionova T, Rodygina E, Samoylova Y, Shestakova M, Shutemova E, Simanenkov V, Simonova G, Stepanovich Yakushin S, Svetlana B, Treshkur T, Tyurina T, Vorozhtsova I, Zanozina O, Zhukova L, Zykova T, Raslova K, Ilavska A, Navratova D, Nemethyova Z, Ochodnicka Z, Teplanova M, Raubenheimer P, Bhorat A, Blom D, Burgess L, Cassimjee S, Ellis G, Fulat M, Gani M, Hansa S, Kruger S, Latiff G, Madlala T, Mitha E, Mitha I, Moore R, Naidoo D, Ramdass A, Raubenheimer P, Roos J, Seeber M, Siebert M, van Zyl L, Wing J, Mellbin L, Ryden L, Berndtsson Blom K, Boström P, Herlitz J, Jensen-Agergaard S, Kempe A, Linderfalk C, Liu B, Mathiesen U, Nilsson J, Norrby A, Rosengren A, Svensson K, Tengmark B, Torstensson I, Vasko P, Chen J, Chen J, Cheng J, Chiang F, Chiou H, Lai W, Wang J, Chaithiraphan S, Krittayaphong R, Silaruks S, Sitthisook S, Sritara P, Sukonthasarn A, Parkhomenko A, Lishnevska V, Panina S, Popik G, Saprychova L, Svyshchenko Y, Tseluyko V, Heller S, Ainsworth P, Cruickshank K, Ellerby L, Falk RM, Gaunt R, Hitman G, Khan A, Linton M, Macklin A, O'Kane M, Reed R, Robinson T, Roman M, Rooney D, Shakher J, Silvert B, Taylor N, Webster J, Probstfield J, Riddle M, Ariani M, Barzilay J, Bilazarian S, Bommer W, Brautigam D, Cushman W, Feinglos M, Force R, Giddings S, Gillespie E, Hamaty M, Haywood L, Hollander P, Karl D, Kashyap M, Linz P, Nicol P, Nyenwe E, Raghavan V, Solbrig R, Sperl J, Sweeney M, White J, Wu P, Wyne K, Afzal R, Arsenault J, Bosch J, Burke M, Castelli J, Forbes B, Gerstein H, Ho L, Joldersma L, Lui S, MacRae L, Marshall T, Ng J, Pogue J, Punthakee Z, Reznick DeMarco Y, Roberts S, Stevens C, Tosta F, Wasala L, Whate A, Yuan F, Yusuf S, Zotova E, Hardman C, Richardson L, White J.

Author information

  • 1Population Health Research Institute, McMaster University, 237 Barton St E., Hamilton, ON, Canada, L8L 2X2. zubin.punthakee@mcmaster.ca

Abstract

AIMS/OBJECTIVE:

Conflicting data regarding cardiovascular effects of thiazolidinediones (TZDs) and extra-skeletal effects of vitamin D supported the need for a definitive trial. The Thiazolidinedione Intervention with vitamin D Evaluation (TIDE) trial aimed to assess the effects of TZDs (rosiglitazone and pioglitazone) on cardiovascular outcomes and the effects of vitamin D (cholecalciferol) on cancers and mortality.

METHODS:

A large multicentre 3 × 2 factorial double-blind placebo-controlled randomised trial recruited from outpatient primary care and specialty clinics in 33 countries. From June 2009 to July 2010, 1,332 people with type 2 diabetes and other cardiovascular risk factors aged ≥ 50 years whose HbA(1c) was 6.5-9.5% (48-80 mmol/mol) when using two or fewer glucose-lowering drugs were randomised by a central computer system to placebo (n = 541), rosiglitazone 4-8 mg/day (n = 399) or pioglitazone 30-45 mg/day (n = 392); 1,221 participants were randomised to placebo (n = 614) or vitamin D 1,000 IU/day (n = 607). Participants and all study personnel were blind to treatment allocation. The primary outcome for the TZD arm was the composite of myocardial infarction, stroke or cardiovascular death, and for the vitamin D arm it was cancer or all-cause death. All randomised participants were included in the primary analysis.

RESULTS:

From the study design, 16,000 people were to be followed for approximately 5.5 years. However, the trial was stopped prematurely because of regulatory concerns after a mean of 162 days without consideration of the accrued data. In the TZD arm, the cardiovascular outcome occurred in five participants (0.9%) in the placebo groups and three participants (0.4%) in the TZD groups (two allocated to pioglitazone, one to rosiglitazone). In the vitamin D arm, the primary outcome occurred in three participants (0.5%) in the placebo group and in two participants (0.3%) receiving vitamin D. Adverse events were comparable in all groups.

CONCLUSIONS/INTERPRETATION:

Uncertainty persists regarding the clinically relevant risks and benefits of TZDs and vitamin D because of the early cancellation of this comprehensive trial.

PMID:
22038523
[PubMed - indexed for MEDLINE]
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