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Isavuconazole absorption following oral administration in healthy subjects is comparable to intravenous dosing, and is not affected by food, or drugs that alter stomach pH.

Schmitt-Hoffmann A, Desai A, Kowalski D, Pearlman H, Yamazaki T, Townsend R.

Int J Clin Pharmacol Ther. 2016 Jun 27. [Epub ahead of print]


Inflammation and Progression of CKD: The CRIC Study.

Amdur RL, Feldman HI, Gupta J, Yang W, Kanetsky P, Shlipak M, Rahman M, Lash JP, Townsend RR, Ojo A, Roy-Chaudhury A, Go AS, Joffe M, He J, Balakrishnan VS, Kimmel PL, Kusek JW, Raj DS; CRIC Study Investigators.

Clin J Am Soc Nephrol. 2016 Jun 23. pii: CJN.13121215. [Epub ahead of print]


Parathyroid Hormone Secretion is Controlled by Both Ionised Calcium and Phosphate During Exercise and Recovery in Men.

Townsend R, Elliott-Sale KJ, Jessica Pinto A, Thomas C, Scott JP, Currell K, Fraser WD, Sale C.

J Clin Endocrinol Metab. 2016 Jun 13:jc20161848. [Epub ahead of print]


Pharmacokinetic and Pharmacodynamic Evaluation of the Drug-Drug Interaction between Isavuconazole and Warfarin in Healthy Subjects.

Desai A, Yamazaki T, Dietz AJ, Kowalski D, Lademacher C, Pearlman H, Akhtar S, Townsend R.

Clin Pharmacol Drug Dev. 2016 Jun 9. doi: 10.1002/cpdd.283. [Epub ahead of print]


Pharmacokinetic Evaluation of CYP3A4-mediated Drug-Drug Interactions of Isavuconazole with Rifampin, Ketoconazole, Midazolam, and Ethinyl Estradiol/Norethindrone in Healthy Adults.

Townsend R, Dietz A, Hale C, Akhtar S, Kowalski D, Lademacher C, Lasseter K, Pearlman H, Rammelsberg D, Schmitt-Hoffmann A, Yamazaki T, Desai A.

Clin Pharmacol Drug Dev. 2016 Jun 8. doi: 10.1002/cpdd.285. [Epub ahead of print]


Pharmacokinetic Assessment of Drug-Drug Interactions of Isavuconazole with the Immunosuppressants Cyclosporine, Mycophenolic Acid, Prednisolone, Sirolimus, and Tacrolimus in Healthy Adults.

Groll AH, Desai A, Han D, Howieson C, Kato K, Akhtar S, Kowalski D, Lademacher C, Lewis W, Pearlman H, Mandarino D, Yamazaki T, Townsend R.

Clin Pharmacol Drug Dev. 2016 Jun 8. doi: 10.1002/cpdd.284. [Epub ahead of print]


Pharmacokinetic Interaction between Isavuconazole and a Fixed-Dose Combination of Lopinavir 400 mg/Ritonavir 100 mg in Healthy Subjects.

Yamazaki T, Desai A, Han D, Kato K, Kowalski D, Akhtar S, Lademacher C, Kovanda L, Townsend R.

Clin Pharmacol Drug Dev. 2016 Jun 8. doi: 10.1002/cpdd.282. [Epub ahead of print]


Pharmacokinetic Effects of Isavuconazole Co-Administration with the Cytochrome P450 Enzyme Substrates Bupropion, Repaglinide, Caffeine, Dextromethorphan, and Methadone in Healthy Subjects.

Yamazaki T, Desai A, Goldwater R, Han D, Howieson C, Akhtar S, Kowalski D, Lademacher C, Pearlman H, Rammelsberg D, Townsend R.

Clin Pharmacol Drug Dev. 2016 Jun 8. doi: 10.1002/cpdd.281. [Epub ahead of print]


Pharmacokinetic Interactions between Isavuconazole and the Drug Transporter Substrates Atorvastatin, Digoxin, Metformin, and Methotrexate in Healthy Subjects.

Yamazaki T, Desai A, Goldwater R, Han D, Lasseter KC, Howieson C, Akhtar S, Kowalski D, Lademacher C, Rammelsberg D, Townsend R.

Clin Pharmacol Drug Dev. 2016 Jun 8. doi: 10.1002/cpdd.280. [Epub ahead of print]


Proteogenomics connects somatic mutations to signalling in breast cancer.

Mertins P, Mani DR, Ruggles KV, Gillette MA, Clauser KR, Wang P, Wang X, Qiao JW, Cao S, Petralia F, Kawaler E, Mundt F, Krug K, Tu Z, Lei JT, Gatza ML, Wilkerson M, Perou CM, Yellapantula V, Huang KL, Lin C, McLellan MD, Yan P, Davies SR, Townsend RR, Skates SJ, Wang J, Zhang B, Kinsinger CR, Mesri M, Rodriguez H, Ding L, Paulovich AG, Fenyƶ D, Ellis MJ, Carr SA; NCI CPTAC.

Nature. 2016 May 25;534(7605):55-62. doi: 10.1038/nature18003.


Ankle Brachial Index and Subsequent Cardiovascular Disease Risk in Patients With Chronic Kidney Disease.

Chen J, Mohler ER 3rd, Garimella PS, Hamm LL, Xie D, Kimmel S, Townsend RR, Budoff M, Pan Q, Nessel L, Steigerwalt S, Wright JT, He J; CRIC Investigators.

J Am Heart Assoc. 2016 May 31;5(6). pii: e003339. doi: 10.1161/JAHA.116.003339.


Variants in genes belonging to the Fibroblast Growth Factor family are associated with lower extremity amputation in non-Hispanic whites: Findings from the Chronic Renal Insufficiency Cohort study.

Gupta J, Mitra N, Townsend RR, Fischer M, Schelling JR, Margolis DJ.

Wound Repair Regen. 2016 May 30. doi: 10.1111/wrr.12447. [Epub ahead of print]


Obesity, Renin-Angiotensin System Blockade and Risk of Adverse Renal Outcomes: A Population-Based Cohort Study.

Cohen JB, Stephens-Shields AJ, Denburg MR, Anderson AH, Townsend RR, Reese PP.

Am J Nephrol. 2016 May 28;43(6):431-440. [Epub ahead of print]


Sodium Excretion and the Risk of Cardiovascular Disease in Patients With Chronic Kidney Disease.

Mills KT, Chen J, Yang W, Appel LJ, Kusek JW, Alper A, Delafontaine P, Keane MG, Mohler E, Ojo A, Rahman M, Ricardo AC, Soliman EZ, Steigerwalt S, Townsend R, He J; Chronic Renal Insufficiency Cohort (CRIC) Study Investigators.

JAMA. 2016 May 24-31;315(20):2200-10. doi: 10.1001/jama.2016.4447.


The Associations between Peripheral Artery Disease and Physical Outcome Measures in Men and Women with Chronic Kidney Disease.

Wang GJ, Shaw PA, Townsend RR, Anderson AH, Xie D, Wang X, Nessel LC, Mohler ER, Sozio SM, Jaar BG, Chen J, Wright J, Taliercio JJ, Ojo A, Ricardo AC, Lustigova E, Fairman RM, Feldman HI, Ky B; CRIC Study Investigators.

Ann Vasc Surg. 2016 May 20. pii: S0890-5096(16)30243-6. doi: 10.1016/j.avsg.2016.02.010. [Epub ahead of print]


Race/Ethnicity and Cardiovascular Outcomes in Adults With CKD: Findings From the CRIC (Chronic Renal Insufficiency Cohort) and Hispanic CRIC Studies.

Lash JP, Ricardo AC, Roy J, Deo R, Fischer M, Flack J, He J, Keane M, Lora C, Ojo A, Rahman M, Steigerwalt S, Tao K, Wolf M, Wright JT Jr, Go AS; CRIC Study Investigators.

Am J Kidney Dis. 2016 May 18. pii: S0272-6386(16)30100-7. doi: 10.1053/j.ajkd.2016.03.429. [Epub ahead of print]


Isavuconazole Population Pharmacokinetic Analysis Using Non-Parametric Estimation in Patients with Invasive Fungal Disease: Results from the VITAL Study.

Kovanda LL, Desai AV, Lu Q, Townsend RW, Akhtar S, Bonate P, Hope WW.

Antimicrob Agents Chemother. 2016 May 16. pii: AAC.00514-16. [Epub ahead of print]


Medication Non-Adherence: A Bigger Problem Than Physicians Assume.

Cohen DL, Townsend RR.

J Clin Hypertens (Greenwich). 2016 May 12. doi: 10.1111/jch.12838. [Epub ahead of print] No abstract available.


"Translational" medicine: transforming SPRINT findings into clinical practice.

Sica DA, Phillips RA, White WB, Bisognano JD, Townsend RR.

J Am Soc Hypertens. 2016 May;10(5):382-6. doi: 10.1016/j.jash.2016.03.192. Epub 2016 Mar 31. No abstract available.


CKD Progression and Mortality among Hispanics and Non-Hispanics.

Fischer MJ, Hsu JY, Lora CM, Ricardo AC, Anderson AH, Bazzano L, Cuevas MM, Hsu CY, Kusek JW, Renteria A, Ojo AO, Raj DS, Rosas SE, Pan Q, Yaffe K, Go AS, Lash JP; Chronic Renal Insufficiency Cohort (CRIC) Study Investigators.

J Am Soc Nephrol. 2016 May 5. pii: ASN.2015050570. [Epub ahead of print]

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