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Results: 1 to 20 of 63

1.

Independent evaluation of the anatomical and behavioral effects of Taxol in rat models of spinal cord injury.

Popovich PG, Tovar CA, Lemeshow S, Yin Q, Jakeman LB.

Exp Neurol. 2014 Jul 3;261C:97-108. doi: 10.1016/j.expneurol.2014.06.020. [Epub ahead of print]

PMID:
24999028
[PubMed - as supplied by publisher]
2.

Discovery of potent and selective spiroindolinone MDM2 inhibitor, RO8994, for cancer therapy.

Zhang Z, Ding Q, Liu JJ, Zhang J, Jiang N, Chu XJ, Bartkovitz D, Luk KC, Janson C, Tovar C, Filipovic ZM, Higgins B, Glenn K, Packman K, Vassilev LT, Graves B.

Bioorg Med Chem. 2014 Aug 1;22(15):4001-9. doi: 10.1016/j.bmc.2014.05.072. Epub 2014 Jun 11.

PMID:
24997575
[PubMed - in process]
3.

Dose reduction of efavirenz: an observational study describing cost-effectiveness, pharmacokinetics and pharmacogenetics.

Martín AS, Gómez AI, García-Berrocal B, Figueroa SC, Sánchez MC, Calvo Hernández MV, Gonzalez-Buitrago JM, Valverde Merino MP, Tovar CB, Martín AF, Isidoro-García M.

Pharmacogenomics. 2014 May;15(7):997-1006. doi: 10.2217/pgs.14.48.

PMID:
24956253
[PubMed - in process]
4.

Discovery of Potent and Orally Active p53-MDM2 Inhibitors RO5353 and RO2468 for Potential Clinical Development.

Zhang Z, Chu XJ, Liu JJ, Ding Q, Zhang J, Bartkovitz D, Jiang N, Karnachi P, So SS, Tovar C, Filipovic ZM, Higgins B, Glenn K, Packman K, Vassilev L, Graves B.

ACS Med Chem Lett. 2013 Dec 29;5(2):124-7. doi: 10.1021/ml400359z. eCollection 2014 Feb 13.

PMID:
24900784
[PubMed]
5.

Discovery of RG7112: A Small-Molecule MDM2 Inhibitor in Clinical Development.

Vu B, Wovkulich P, Pizzolato G, Lovey A, Ding Q, Jiang N, Liu JJ, Zhao C, Glenn K, Wen Y, Tovar C, Packman K, Vassilev L, Graves B.

ACS Med Chem Lett. 2013 Apr 2;4(5):466-9. doi: 10.1021/ml4000657. eCollection 2013 May 9.

PMID:
24900694
[PubMed]
Free PMC Article
6.

Preclinical optimization of MDM2 antagonist scheduling for cancer treatment by using a model-based approach.

Higgins B, Glenn K, Walz A, Tovar C, Filipovic Z, Hussain S, Lee E, Kolinsky K, Tannu S, Adames V, Garrido R, Linn M, Meille C, Heimbrook D, Vassilev L, Packman K.

Clin Cancer Res. 2014 Jul 15;20(14):3742-52. doi: 10.1158/1078-0432.CCR-14-0460. Epub 2014 May 8.

PMID:
24812409
[PubMed - in process]
7.

Identification of dendritic cells, B cell and T cell subsets in Tasmanian devil lymphoid tissue; evidence for poor immune cell infiltration into devil facial tumors.

Howson LJ, Morris KM, Kobayashi T, Tovar C, Kreiss A, Papenfuss AT, Corcoran L, Belov K, Woods GM.

Anat Rec (Hoboken). 2014 May;297(5):925-38. doi: 10.1002/ar.22904. Epub 2014 Mar 24.

PMID:
24664954
[PubMed - in process]
Free PMC Article
8.

Low-dose amphotericin B and murine dialyzable spleen extracts protect against systemic candida infection in mice.

Robledo-Ávila F, Pérez-Tapia M, Limón-Flores A, Pavon L, Hernández-Pando R, Wong-Baeza I, González-González G, Tovar C, Estrada-Parra S, Estrada-García I.

Clin Dev Immunol. 2013;2013:194064. doi: 10.1155/2013/194064. Epub 2013 Sep 10.

PMID:
24106515
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Stapled α-helical peptide drug development: a potent dual inhibitor of MDM2 and MDMX for p53-dependent cancer therapy.

Chang YS, Graves B, Guerlavais V, Tovar C, Packman K, To KH, Olson KA, Kesavan K, Gangurde P, Mukherjee A, Baker T, Darlak K, Elkin C, Filipovic Z, Qureshi FZ, Cai H, Berry P, Feyfant E, Shi XE, Horstick J, Annis DA, Manning AM, Fotouhi N, Nash H, Vassilev LT, Sawyer TK.

Proc Natl Acad Sci U S A. 2013 Sep 3;110(36):E3445-54. doi: 10.1073/pnas.1303002110. Epub 2013 Aug 14.

PMID:
23946421
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Determining the response of African biota to climate change: using the past to model the future.

Willis KJ, Bennett KD, Burrough SL, Macias-Fauria M, Tovar C.

Philos Trans R Soc Lond B Biol Sci. 2013 Jul 22;368(1625):20120491. doi: 10.1098/rstb.2012.0491. Print 2013. Review.

PMID:
23878343
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Discovery of RG7388, a potent and selective p53-MDM2 inhibitor in clinical development.

Ding Q, Zhang Z, Liu JJ, Jiang N, Zhang J, Ross TM, Chu XJ, Bartkovitz D, Podlaski F, Janson C, Tovar C, Filipovic ZM, Higgins B, Glenn K, Packman K, Vassilev LT, Graves B.

J Med Chem. 2013 Jul 25;56(14):5979-83. doi: 10.1021/jm400487c. Epub 2013 Jul 16.

PMID:
23808545
[PubMed - indexed for MEDLINE]
12.

Diverging responses of tropical Andean biomes under future climate conditions.

Tovar C, Arnillas CA, Cuesta F, Buytaert W.

PLoS One. 2013 May 7;8(5):e63634. doi: 10.1371/journal.pone.0063634. Print 2013.

PMID:
23667651
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Reversible epigenetic down-regulation of MHC molecules by devil facial tumour disease illustrates immune escape by a contagious cancer.

Siddle HV, Kreiss A, Tovar C, Yuen CK, Cheng Y, Belov K, Swift K, Pearse AM, Hamede R, Jones ME, Skjødt K, Woods GM, Kaufman J.

Proc Natl Acad Sci U S A. 2013 Mar 26;110(13):5103-8. doi: 10.1073/pnas.1219920110. Epub 2013 Mar 11.

PMID:
23479617
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Discovery of a highly potent, orally active mitosis/angiogenesis inhibitor r1530 for the treatment of solid tumors.

Liu JJ, Higgins B, Ju G, Kolinsky K, Luk KC, Packman K, Pizzolato G, Ren Y, Thakkar K, Tovar C, Zhang Z, Wovkulich PM.

ACS Med Chem Lett. 2013 Jan 15;4(2):259-63. doi: 10.1021/ml300351e. eCollection 2013 Feb 14.

PMID:
24900658
[PubMed]
Free PMC Article
15.

MDM2 small-molecule antagonist RG7112 activates p53 signaling and regresses human tumors in preclinical cancer models.

Tovar C, Graves B, Packman K, Filipovic Z, Higgins B, Xia M, Tardell C, Garrido R, Lee E, Kolinsky K, To KH, Linn M, Podlaski F, Wovkulich P, Vu B, Vassilev LT.

Cancer Res. 2013 Apr 15;73(8):2587-97. doi: 10.1158/0008-5472.CAN-12-2807. Epub 2013 Feb 11.

PMID:
23400593
[PubMed - indexed for MEDLINE]
Free Article
16.

Activation of the p53 pathway by small-molecule-induced MDM2 and MDMX dimerization.

Graves B, Thompson T, Xia M, Janson C, Lukacs C, Deo D, Di Lello P, Fry D, Garvie C, Huang KS, Gao L, Tovar C, Lovey A, Wanner J, Vassilev LT.

Proc Natl Acad Sci U S A. 2012 Jul 17;109(29):11788-93. doi: 10.1073/pnas.1203789109. Epub 2012 Jun 28.

PMID:
22745160
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Tumor necrosis factor alpha mediates GABA(A) receptor trafficking to the plasma membrane of spinal cord neurons in vivo.

Stück ED, Christensen RN, Huie JR, Tovar CA, Miller BA, Nout YS, Bresnahan JC, Beattie MS, Ferguson AR.

Neural Plast. 2012;2012:261345. doi: 10.1155/2012/261345. Epub 2012 Mar 12.

PMID:
22530155
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Topiramate treatment is neuroprotective and reduces oligodendrocyte loss after cervical spinal cord injury.

Gensel JC, Tovar CA, Bresnahan JC, Beattie MS.

PLoS One. 2012;7(3):e33519. doi: 10.1371/journal.pone.0033519. Epub 2012 Mar 13.

PMID:
22428066
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Plant and animal endemism in the eastern Andean slope: challenges to conservation.

Swenson JJ, Young BE, Beck S, Comer P, Córdova JH, Dyson J, Embert D, Encarnación F, Ferreira W, Franke I, Grossman D, Hernandez P, Herzog SK, Josse C, Navarro G, Pacheco V, Stein BA, Timaná M, Tovar A, Tovar C, Vargas J, Zambrana-Torrelio CM.

BMC Ecol. 2012 Jan 27;12:1. doi: 10.1186/1472-6785-12-1.

PMID:
22284854
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

A reassessment of a classic neuroprotective combination therapy for spinal cord injured rats: LPS/pregnenolone/indomethacin.

Popovich PG, Tovar CA, Wei P, Fisher L, Jakeman LB, Basso DM.

Exp Neurol. 2012 Feb;233(2):677-85. doi: 10.1016/j.expneurol.2011.11.045. Epub 2011 Dec 8.

PMID:
22177997
[PubMed - indexed for MEDLINE]
Free PMC Article

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