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Results: 14


Genome-wide association study identifies shared risk loci common to two malignancies in golden retrievers.

Tonomura N, Elvers I, Thomas R, Megquier K, Turner-Maier J, Howald C, Sarver AL, Swofford R, Frantz AM, Ito D, Mauceli E, Arendt M, Noh HJ, Koltookian M, Biagi T, Fryc S, Williams C, Avery AC, Kim JH, Barber L, Burgess K, Lander ES, Karlsson EK, Azuma C, Modiano JF, Breen M, Lindblad-Toh K.

PLoS Genet. 2015 Feb 2;11(2):e1004922. doi: 10.1371/journal.pgen.1004922. eCollection 2015 Feb.


Canine hereditary ataxia in old english sheepdogs and gordon setters is associated with a defect in the autophagy gene encoding RAB24.

Agler C, Nielsen DM, Urkasemsin G, Singleton A, Tonomura N, Sigurdsson S, Tang R, Linder K, Arepalli S, Hernandez D, Lindblad-Toh K, van de Leemput J, Motsinger-Reif A, O'Brien DP, Bell J, Harris T, Steinberg S, Olby NJ.

PLoS Genet. 2014 Feb 6;10(2):e1003991. doi: 10.1371/journal.pgen.1003991. eCollection 2014 Feb.


Genome-wide analyses implicate 33 loci in heritable dog osteosarcoma, including regulatory variants near CDKN2A/B.

Karlsson EK, Sigurdsson S, Ivansson E, Thomas R, Elvers I, Wright J, Howald C, Tonomura N, Perloski M, Swofford R, Biagi T, Fryc S, Anderson N, Courtay-Cahen C, Youell L, Ricketts SL, Mandlebaum S, Rivera P, von Euler H, Kisseberth WC, London CA, Lander ES, Couto G, Comstock K, Starkey MP, Modiano JF, Breen M, Lindblad-Toh K.

Genome Biol. 2013 Dec 12;14(12):R132. doi: 10.1186/gb-2013-14-12-r132.


Thorough investigation of a canine autoinflammatory disease (AID) confirms one main risk locus and suggests a modifier locus for amyloidosis.

Olsson M, Tintle L, Kierczak M, Perloski M, Tonomura N, Lundquist A, Murén E, Fels M, Tengvall K, Pielberg G, Dufaure de Citres C, Dorso L, Abadie J, Hanson J, Thomas A, Leegwater P, Hedhammar Å, Lindblad-Toh K, Meadows JR.

PLoS One. 2013 Oct 9;8(10):e75242. doi: 10.1371/journal.pone.0075242. eCollection 2013.


A novel unstable duplication upstream of HAS2 predisposes to a breed-defining skin phenotype and a periodic fever syndrome in Chinese Shar-Pei dogs.

Olsson M, Meadows JR, Truvé K, Rosengren Pielberg G, Puppo F, Mauceli E, Quilez J, Tonomura N, Zanna G, Docampo MJ, Bassols A, Avery AC, Karlsson EK, Thomas A, Kastner DL, Bongcam-Rudloff E, Webster MT, Sanchez A, Hedhammar A, Remmers EF, Andersson L, Ferrer L, Tintle L, Lindblad-Toh K.

PLoS Genet. 2011 Mar;7(3):e1001332. doi: 10.1371/journal.pgen.1001332. Epub 2011 Mar 17.


Pig islet xenograft rejection in a mouse model with an established human immune system.

Tonomura N, Shimizu A, Wang S, Yamada K, Tchipashvili V, Weir GC, Yang YG.

Xenotransplantation. 2008 Mar-Apr;15(2):129-35. doi: 10.1111/j.1399-3089.2008.00450.x.


Antigen-specific human T-cell responses and T cell-dependent production of human antibodies in a humanized mouse model.

Tonomura N, Habiro K, Shimizu A, Sykes M, Yang YG.

Blood. 2008 Apr 15;111(8):4293-6. doi: 10.1182/blood-2007-11-121319. Epub 2008 Feb 12.


Hyperbaric oxygen: a potential new therapy for leukemia?

Tonomura N, Granowitz EV.

Leuk Res. 2007 Jun;31(6):745-6. Epub 2007 Feb 2. Review. No abstract available.


Hyperbaric oxygen inhibits benign and malignant human mammary epithelial cell proliferation.

Granowitz EV, Tonomura N, Benson RM, Katz DM, Band V, Makari-Judson GP, Osborne BA.

Anticancer Res. 2005 Nov-Dec;25(6B):3833-42.


Glucocorticoid-induced apoptosis of thymocytes: requirement of proteasome-dependent mitochondrial activity.

Tonomura N, McLaughlin K, Grimm L, Goldsby RA, Osborne BA.

J Immunol. 2003 Mar 1;170(5):2469-78.


Hyperbaric oxygen enhances apoptosis in hematopoietic cells.

Ganguly BJ, Tonomura N, Benson RM, Osborne BA, Granowitz EV.

Apoptosis. 2002 Dec;7(6):499-510.


Negative regulation of immediate-early gene expression of pseudorabies virus by interferon-alpha.

Tonomura N, Ono E, Shimizu Y, Kida H.

Vet Microbiol. 1996 Dec;53(3-4):271-81.


Inhibition of pseudorabies virus replication by a chimeric trans-gene product repressing transcription of the immediate-early gene.

Ono E, Sakoda Y, Taharaguchi S, Watanabe S, Tonomura N, Kida H, Shimizu Y.

Virology. 1995 Jun 20;210(1):128-40.

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