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Items: 18


Computational and biophysical approaches to protein-protein interaction inhibition of Plasmodium falciparum AMA1/RON2 complex.

Pihan E, Delgadillo RF, Tonkin ML, Pugnière M, Lebrun M, Boulanger MJ, Douguet D.

J Comput Aided Mol Des. 2015 Jun;29(6):525-39. doi: 10.1007/s10822-015-9842-7. Epub 2015 Mar 31.


The shear stress of host cell invasion: exploring the role of biomolecular complexes.

Tonkin ML, Boulanger MJ.

PLoS Pathog. 2015 Jan 28;11(1):e1004539. doi: 10.1371/journal.ppat.1004539. eCollection 2015 Jan. Review. No abstract available.


Structural and functional divergence of the aldolase fold in Toxoplasma gondii.

Tonkin ML, Halavaty AS, Ramaswamy R, Ruan J, Igarashi M, Ngô HM, Boulanger MJ.

J Mol Biol. 2015 Feb 27;427(4):840-52. doi: 10.1016/j.jmb.2014.09.019. Epub 2014 Oct 2.


Immunization with a functional protein complex required for erythrocyte invasion protects against lethal malaria.

Srinivasan P, Ekanem E, Diouf A, Tonkin ML, Miura K, Boulanger MJ, Long CA, Narum DL, Miller LH.

Proc Natl Acad Sci U S A. 2014 Jul 15;111(28):10311-6. doi: 10.1073/pnas.1409928111. Epub 2014 Jun 23.


Plasticity and redundancy among AMA-RON pairs ensure host cell entry of Toxoplasma parasites.

Lamarque MH, Roques M, Kong-Hap M, Tonkin ML, Rugarabamu G, Marq JB, Penarete-Vargas DM, Boulanger MJ, Soldati-Favre D, Lebrun M.

Nat Commun. 2014 Jun 17;5:4098. doi: 10.1038/ncomms5098.


The inner membrane complex sub-compartment proteins critical for replication of the apicomplexan parasite Toxoplasma gondii adopt a pleckstrin homology fold.

Tonkin ML, Beck JR, Bradley PJ, Boulanger MJ.

J Biol Chem. 2014 May 16;289(20):13962-73. doi: 10.1074/jbc.M114.548891. Epub 2014 Mar 27.


The multifunctional role of the pallilysin-associated Treponema pallidum protein, Tp0750, in promoting fibrinolysis and extracellular matrix component degradation.

Houston S, Russell S, Hof R, Roberts AK, Cullen P, Irvine K, Smith DS, Borchers CH, Tonkin ML, Boulanger MJ, Cameron CE.

Mol Microbiol. 2014 Feb;91(3):618-34. doi: 10.1111/mmi.12482. Epub 2014 Jan 7.


Toxoplasma gondii sporozoites invade host cells using two novel paralogues of RON2 and AMA1.

Poukchanski A, Fritz HM, Tonkin ML, Treeck M, Boulanger MJ, Boothroyd JC.

PLoS One. 2013 Aug 5;8(8):e70637. doi: 10.1371/journal.pone.0070637. Print 2013.


Structural and biochemical characterization of Plasmodium falciparum 12 (Pf12) reveals a unique interdomain organization and the potential for an antiparallel arrangement with Pf41.

Tonkin ML, Arredondo SA, Loveless BC, Serpa JJ, Makepeace KA, Sundar N, Petrotchenko EV, Miller LH, Grigg ME, Boulanger MJ.

J Biol Chem. 2013 May 3;288(18):12805-17. doi: 10.1074/jbc.M113.455667. Epub 2013 Mar 19.


Purification, crystallization and X-ray diffraction analysis of Trypanosoma congolense insect-stage surface antigen (TcCISSA).

Tonkin ML, Workman SD, Eyford BA, Loveless BC, Fudge JL, Pearson TW, Boulanger MJ.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Dec 1;68(Pt 12):1503-6. doi: 10.1107/S1744309112042686. Epub 2012 Nov 14.


Purification, crystallization and preliminary X-ray diffraction analysis of inner membrane complex (IMC) subcompartment protein 1 (ISP1) from Toxoplasma gondii.

Tonkin ML, Brown S, Beck JR, Bradley PJ, Boulanger MJ.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Jul 1;68(Pt 7):832-4. doi: 10.1107/S174430911202297X. Epub 2012 Jun 28.


Structural characterization of S100A15 reveals a novel zinc coordination site among S100 proteins and altered surface chemistry with functional implications for receptor binding.

Murray JI, Tonkin ML, Whiting AL, Peng F, Farnell B, Cullen JT, Hof F, Boulanger MJ.

BMC Struct Biol. 2012 Jul 2;12:16. doi: 10.1186/1472-6807-12-16.


Structural and functional insights into the malaria parasite moving junction complex.

Vulliez-Le Normand B, Tonkin ML, Lamarque MH, Langer S, Hoos S, Roques M, Saul FA, Faber BW, Bentley GA, Boulanger MJ, Lebrun M.

PLoS Pathog. 2012;8(6):e1002755. doi: 10.1371/journal.ppat.1002755. Epub 2012 Jun 21.


Host cell invasion by apicomplexan parasites: insights from the co-structure of AMA1 with a RON2 peptide.

Tonkin ML, Roques M, Lamarque MH, Pugnière M, Douguet D, Crawford J, Lebrun M, Boulanger MJ.

Science. 2011 Jul 22;333(6041):463-7. doi: 10.1126/science.1204988.


Apicomplexan parasite adhesins: novel strategies for targeting host cell carbohydrates.

Boulanger MJ, Tonkin ML, Crawford J.

Curr Opin Struct Biol. 2010 Oct;20(5):551-9. doi: 10.1016/ Epub 2010 Sep 16. Review.


Structure of the micronemal protein 2 A/I domain from Toxoplasma gondii.

Tonkin ML, Grujic O, Pearce M, Crawford J, Boulanger MJ.

Protein Sci. 2010 Oct;19(10):1985-90. doi: 10.1002/pro.477.


Structural characterization of apical membrane antigen 1 (AMA1) from Toxoplasma gondii.

Crawford J, Tonkin ML, Grujic O, Boulanger MJ.

J Biol Chem. 2010 May 14;285(20):15644-52. doi: 10.1074/jbc.M109.092619. Epub 2010 Mar 19.

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