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Results: 1 to 20 of 31

1.

Mutation of mouse Samd4 causes leanness, myopathy, uncoupled mitochondrial respiration, and dysregulated mTORC1 signaling.

Chen Z, Holland W, Shelton JM, Ali A, Zhan X, Won S, Tomisato W, Liu C, Li X, Moresco EM, Beutler B.

Proc Natl Acad Sci U S A. 2014 May 20;111(20):7367-72. doi: 10.1073/pnas.1406511111. Epub 2014 May 5.

2.

ENU-induced phenovariance in mice: inferences from 587 mutations.

Arnold CN, Barnes MJ, Berger M, Blasius AL, Brandl K, Croker B, Crozat K, Du X, Eidenschenk C, Georgel P, Hoebe K, Huang H, Jiang Z, Krebs P, La Vine D, Li X, Lyon S, Moresco EM, Murray AR, Popkin DL, Rutschmann S, Siggs OM, Smart NG, Sun L, Tabeta K, Webster V, Tomisato W, Won S, Xia Y, Xiao N, Beutler B.

BMC Res Notes. 2012 Oct 24;5:577. doi: 10.1186/1756-0500-5-577.

3.

Yip1 domain family, member 6 (Yipf6) mutation induces spontaneous intestinal inflammation in mice.

Brandl K, Tomisato W, Li X, Neppl C, Pirie E, Falk W, Xia Y, Moresco EM, Baccala R, Theofilopoulos AN, Schnabl B, Beutler B.

Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):12650-5. doi: 10.1073/pnas.1210366109. Epub 2012 Jul 16.

4.

iRhom2 is required for the secretion of mouse TNFα.

Siggs OM, Xiao N, Wang Y, Shi H, Tomisato W, Li X, Xia Y, Beutler B.

Blood. 2012 Jun 14;119(24):5769-71. doi: 10.1182/blood-2012-03-417949. Epub 2012 May 1.

5.

Synthesis and SAR of 1,3-thiazolyl thiophene and pyridine derivatives as potent, orally active and S1P₃-sparing S1P₁ agonists.

Asano M, Nakamura T, Sekiguchi Y, Mizuno Y, Yamaguchi T, Tamaki K, Shimozato T, Doi-Komuro H, Kagari T, Tomisato W, Inoue R, Yuita H, Oguchi-Oshima K, Kaneko R, Nara F, Kawase Y, Masubuchi N, Nakayama S, Koga T, Namba E, Nasu H, Nishi T.

Bioorg Med Chem Lett. 2012 May 1;22(9):3083-8. doi: 10.1016/j.bmcl.2012.03.067. Epub 2012 Mar 23.

PMID:
22487179
6.

Synthesis and evaluation of CS-2100, a potent, orally active and S1P(3)- sparing S1P(1) agonist.

Nakamura T, Asano M, Sekiguchi Y, Mizuno Y, Tamaki K, Nara F, Kawase Y, Yabe Y, Nakai D, Kamiyama E, Urasaki-Kaneno Y, Shimozato T, Doi-Komuro H, Kagari T, Tomisato W, Inoue R, Nagasaki M, Yuita H, Oguchi-Oshima K, Kaneko R, Nishi T.

Eur J Med Chem. 2012 May;51:92-8. doi: 10.1016/j.ejmech.2012.02.022. Epub 2012 Feb 25.

PMID:
22405291
7.

Discovery of CS-2100, a potent, orally active and S1P3-sparing S1P1 agonist.

Nakamura T, Asano M, Sekiguchi Y, Mizuno Y, Tamaki K, Kimura T, Nara F, Kawase Y, Shimozato T, Doi H, Kagari T, Tomisato W, Inoue R, Nagasaki M, Yuita H, Oguchi-Oshima K, Kaneko R, Watanabe N, Abe Y, Nishi T.

Bioorg Med Chem Lett. 2012 Feb 15;22(4):1788-92. doi: 10.1016/j.bmcl.2011.12.019. Epub 2012 Jan 2.

PMID:
22264485
8.

Inflammatory bowel disease and ADAM17 deletion.

Brandl K, Tomisato W, Beutler B.

N Engl J Med. 2012 Jan 12;366(2):190; author reply 190. doi: 10.1056/NEJMc1113859#SA1. No abstract available.

PMID:
22236242
9.

Discovery of CS-0777: A Potent, Selective, and Orally Active S1P1 Agonist.

Nishi T, Miyazaki S, Takemoto T, Suzuki K, Iio Y, Nakajima K, Ohnuki T, Kawase Y, Nara F, Inaba S, Izumi T, Yuita H, Oshima K, Doi H, Inoue R, Tomisato W, Kagari T, Shimozato T.

ACS Med Chem Lett. 2011 Mar 2;2(5):368-72. doi: 10.1021/ml100301k. eCollection 2011 May 12.

10.

MyD88 signaling in nonhematopoietic cells protects mice against induced colitis by regulating specific EGF receptor ligands.

Brandl K, Sun L, Neppl C, Siggs OM, Le Gall SM, Tomisato W, Li X, Du X, Maennel DN, Blobel CP, Beutler B.

Proc Natl Acad Sci U S A. 2010 Nov 16;107(46):19967-72. doi: 10.1073/pnas.1014669107. Epub 2010 Nov 1.

11.

Low direct cytotoxicity and cytoprotective effects of nitric oxide releasing indomethacin.

Tomisato W, Tanaka K, Tsutsumi S, Hoshino T, Yokomizo K, Suzuki K, Katsu T, Mizushima T, Mizushima T.

Dig Dis Sci. 2005 Oct;50(10):1927-37.

PMID:
16187199
12.

Low direct cytotoxicity of nabumetone on gastric mucosal cells.

Arai Y, Tanaka K, Ushijima H, Tomisato W, Tsutsumi S, Aburaya M, Hoshino T, Yokomizo K, Suzuki K, Katsu T, Tsuchiya T, Mizushima T.

Dig Dis Sci. 2005 Sep;50(9):1641-6.

PMID:
16133963
13.

Involvement of intracellular Ca2+ levels in nonsteroidal anti-inflammatory drug-induced apoptosis.

Tanaka K, Tomisato W, Hoshino T, Ishihara T, Namba T, Aburaya M, Katsu T, Suzuki K, Tsutsumi S, Mizushima T.

J Biol Chem. 2005 Sep 2;280(35):31059-67. Epub 2005 Jun 29.

14.

Induction of claudin-4 by nonsteroidal anti-inflammatory drugs and its contribution to their chemopreventive effect.

Mima S, Tsutsumi S, Ushijima H, Takeda M, Fukuda I, Yokomizo K, Suzuki K, Sano K, Nakanishi T, Tomisato W, Tsuchiya T, Mizushima T.

Cancer Res. 2005 Mar 1;65(5):1868-76.

15.

Membrane permeabilization by non-steroidal anti-inflammatory drugs.

Tomisato W, Tanaka K, Katsu T, Kakuta H, Sasaki K, Tsutsumi S, Hoshino T, Aburaya M, Li D, Tsuchiya T, Suzuki K, Yokomizo K, Mizushima T.

Biochem Biophys Res Commun. 2004 Oct 22;323(3):1032-9.

PMID:
15381103
16.

Cytotoxic synergy between indomethacin and hydrochloric acid in gastric mucosal cells.

Tanaka K, Tomisato W, Tsutsumi S, Hoshino T, Tsuchiya T, Mizushima T.

Biol Pharm Bull. 2004 Aug;27(8):1188-92.

17.

Endoplasmic reticulum stress response is involved in nonsteroidal anti-inflammatory drug-induced apoptosis.

Tsutsumi S, Gotoh T, Tomisato W, Mima S, Hoshino T, Hwang HJ, Takenaka H, Tsuchiya T, Mori M, Mizushima T.

Cell Death Differ. 2004 Sep;11(9):1009-16.

18.

Adaptive cytoprotection induced by pretreatment with ethanol protects against gastric cell damage by NSAIDs.

Tanaka K, Nishimoto K, Tomisato W, Tsutsumi S, Hoshino T, Tsuchiya T, Mizushima T.

Dig Dis Sci. 2004 Feb;49(2):210-7.

PMID:
15104359
19.

Role of direct cytotoxic effects of NSAIDs in the induction of gastric lesions.

Tomisato W, Tsutsumi S, Hoshino T, Hwang HJ, Mio M, Tsuchiya T, Mizushima T.

Biochem Pharmacol. 2004 Feb 1;67(3):575-85.

PMID:
15037209
20.

Molecular mechanism of adaptive cytoprotection induced by ethanol in human gastric cells.

Tsutsumi S, Mima S, Tomisato W, Hoshino T, Tsuchiya T, Mizushima T.

Exp Biol Med (Maywood). 2003 Oct;228(9):1089-95.

PMID:
14530521
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