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Protection against experimental melioidosis with a synthetic manno-heptopyranose hexasaccharide glycoconjugate.

Scott AE, Christ WJ, George AJ, Stokes MG, Lohman GJ, Guo Y, Jones M, Titball RW, Atkins TP, Campbell AS, Prior JL.

Bioconjug Chem. 2016 Apr 28. [Epub ahead of print]


Cryo-EM structure of lysenin pore elucidates membrane insertion by an aerolysin family protein.

Bokori-Brown M, Martin TG, Naylor CE, Basak AK, Titball RW, Savva CG.

Nat Commun. 2016 Apr 6;7:11293. doi: 10.1038/ncomms11293.


Red Blood Cell Susceptibility to Pneumolysin: Correlation with Membrane Biochemical and Physical Properties.

Bokori-Brown M, Petrov PG, Khafaji MA, Mughal MK, Naylor CE, Shore AC, Gooding KM, Casanova F, Mitchell TJ, Titball RW, Winlove CP.

J Biol Chem. 2016 Mar 16. pii: jbc.M115.691899. [Epub ahead of print]


Immunisation with proteins expressed during chronic murine melioidosis provides enhanced protection against disease.

Champion OL, Gourlay LJ, Scott AE, Lassaux P, Conejero L, Perletti L, Hemsley C, Prior J, Bancroft G, Bolognesi M, Titball RW.

Vaccine. 2016 Mar 29;34(14):1665-71. doi: 10.1016/j.vaccine.2016.02.038. Epub 2016 Feb 23.


Variable protection against experimental broiler necrotic enteritis after immunisation with the C-terminal fragment of Clostridium perfringens alpha-toxin and a non-toxic NetB variant.

Fernandes da Costa SP, Mot D, Geeraerts S, Bokori-Brown M, Immerseel FV, Titball RW.

Avian Pathol. 2016 Jan 8:1-26. [Epub ahead of print]


Burkholderia pseudomallei kynB plays a role in AQ production, biofilm formation, bacterial swarming and persistence.

Butt A, Halliday N, Williams P, Atkins HS, Bancroft GJ, Titball RW.

Res Microbiol. 2016 Apr;167(3):159-67. doi: 10.1016/j.resmic.2015.11.002. Epub 2015 Nov 30.


Draft Genome Sequence of the Enteropathogenic Bacterium Campylobacter jejuni Strain cj255.

Siddiqui FM, Ibrahim M, Noureen N, Noreen Z, Titball RW, Champion OL, Wren BW, Studholme D, Bokhari H.

Genome Announc. 2015 Oct 22;3(5). pii: e01223-15. doi: 10.1128/genomeA.01223-15.


Functional Analysis of the Role of Toxin-Antitoxin (TA) Loci in Bacterial Persistence.

Butt AT, Titball RW.

Methods Mol Biol. 2016;1333:121-9. doi: 10.1007/978-1-4939-2854-5_11.


Evaluation of antibiotic efficacy against infections caused by planktonic or biofilm cultures of Pseudomonas aeruginosa and Klebsiella pneumoniae in Galleria mellonella.

Benthall G, Touzel RE, Hind CK, Titball RW, Sutton JM, Thomas RJ, Wand ME.

Int J Antimicrob Agents. 2015 Nov;46(5):538-45. doi: 10.1016/j.ijantimicag.2015.07.014. Epub 2015 Aug 31.


Clostridium perfringens╬▒-toxin interaction with red cells and model membranes.

Jewell SA, Titball RW, Huyet J, Naylor CE, Basak AK, Gologan P, Winlove CP, Petrov PG.

Soft Matter. 2015 Oct 21;11(39):7748-61. doi: 10.1039/c5sm00876j. Epub 2015 Aug 25.


Macroautophagy is essential for killing of intracellular Burkholderia pseudomallei in human neutrophils.

Rinchai D, Riyapa D, Buddhisa S, Utispan K, Titball RW, Stevens MP, Stevens JM, Ogawa M, Tanida I, Koike M, Uchiyama Y, Ato M, Lertmemongkolchai G.

Autophagy. 2015;11(5):748-55. doi: 10.1080/15548627.2015.1040969.


Protection of non-human primates against glanders with a gold nanoparticle glycoconjugate vaccine.

Torres AG, Gregory AE, Hatcher CL, Vinet-Oliphant H, Morici LA, Titball RW, Roy CJ.

Vaccine. 2015 Jan 29;33(5):686-92. doi: 10.1016/j.vaccine.2014.11.057. Epub 2014 Dec 19.


Differences in carbon source utilisation distinguish Campylobacter jejuni from Campylobacter coli.

Wagley S, Newcombe J, Laing E, Yusuf E, Sambles CM, Studholme DJ, La Ragione RM, Titball RW, Champion OL.

BMC Microbiol. 2014 Oct 28;14:262. doi: 10.1186/s12866-014-0262-y.


Transcriptional profiles of Burkholderia pseudomallei reveal the direct and indirect roles of Sigma E under oxidative stress conditions.

Jitprasutwit S, Ong C, Juntawieng N, Ooi WF, Hemsley CM, Vattanaviboon P, Titball RW, Tan P, Korbsrisate S.

BMC Genomics. 2014 Sep 12;15:787. doi: 10.1186/1471-2164-15-787.


A gold nanoparticle-linked glycoconjugate vaccine against Burkholderia mallei.

Gregory AE, Judy BM, Qazi O, Blumentritt CA, Brown KA, Shaw AM, Torres AG, Titball RW.

Nanomedicine. 2015 Feb;11(2):447-56. doi: 10.1016/j.nano.2014.08.005. Epub 2014 Sep 3.


Bacterial drug tolerance under clinical conditions is governed by anaerobic adaptation but not anaerobic respiration.

Hemsley CM, Luo JX, Andreae CA, Butler CS, Soyer OS, Titball RW.

Antimicrob Agents Chemother. 2014 Oct;58(10):5775-83. doi: 10.1128/AAC.02793-14. Epub 2014 Jul 21.


Protection against experimental melioidosis following immunisation with a lipopolysaccharide-protein conjugate.

Scott AE, Ngugi SA, Laws TR, Corser D, Lonsdale CL, D'Elia RV, Titball RW, Williamson ED, Atkins TP, Prior JL.

J Immunol Res. 2014;2014:392170. doi: 10.1155/2014/392170. Epub 2014 May 7.


Identification of possible virulence marker from Campylobacter jejuni isolates.

Harrison JW, Dung TT, Siddiqui F, Korbrisate S, Bukhari H, Tra MP, Hoang NV, Carrique-Mas J, Bryant J, Campbell JI, Studholme DJ, Wren BW, Baker S, Titball RW, Champion OL.

Emerg Infect Dis. 2014 Jun;20(6):1026-9. doi: 10.3201/eid2006.130635.


Clostridium perfringens epsilon toxin mutant Y30A-Y196A as a recombinant vaccine candidate against enterotoxemia.

Bokori-Brown M, Hall CA, Vance C, Fernandes da Costa SP, Savva CG, Naylor CE, Cole AR, Basak AK, Moss DS, Titball RW.

Vaccine. 2014 May 13;32(23):2682-7. doi: 10.1016/j.vaccine.2014.03.079. Epub 2014 Apr 5.


Identification of a key residue for oligomerisation and pore-formation of Clostridium perfringens NetB.

Fernandes da Costa SP, Savva CG, Bokori-Brown M, Naylor CE, Moss DS, Basak AK, Titball RW.

Toxins (Basel). 2014 Mar 12;6(3):1049-61. doi: 10.3390/toxins6031049.

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