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    Results: 1 to 20 of 193

    1.

    Designed compounds for recognition of 10 base pairs of DNA with two at binding sites.

    Liu Y, Chai Y, Kumar A, Tidwell RR, Boykin DW, Wilson WD.

    J Am Chem Soc. 2012 Mar 21;134(11):5290-9. Epub 2012 Mar 9.

    PMID:
    22369366
    [PubMed - in process]
    2.

    A semiphysiologically based pharmacokinetic modeling approach to predict the dose-exposure relationship of an antiparasitic prodrug/active metabolite pair.

    Yan GZ, Generaux CN, Yoon M, Goldsmith RB, Tidwell RR, Hall JE, Olson CA, Clewell HJ, Brouwer KL, Paine MF.

    Drug Metab Dispos. 2012 Jan;40(1):6-17. Epub 2011 Sep 27.

    PMID:
    21953913
    [PubMed - in process]
    3.

    Prevalence of human African trypanosomiasis in the Democratic Republic of the Congo.

    Mumba D, Bohorquez E, Messina J, Kande V, Taylor SM, Tshefu AK, Muwonga J, Kashamuka MM, Emch M, Tidwell R, Büscher P, Meshnick SR.

    PLoS Negl Trop Dis. 2011 Aug;5(8):e1246. Epub 2011 Aug 2.

    PMID:
    21829736
    [PubMed - indexed for MEDLINE]
    Free PMC Article
    4.

    Novel diamidines with activity against Babesia divergens in vitro and Babesia microti in vivo.

    Nehrbass-Stuedli A, Boykin D, Tidwell RR, Brun R.

    Antimicrob Agents Chemother. 2011 Jul;55(7):3439-45. Epub 2011 May 2.

    PMID:
    21537025
    [PubMed - indexed for MEDLINE]
    Free PMC Article
    5.

    Mechanisms underlying differences in systemic exposure of structurally similar active metabolites: comparison of two preclinical hepatic models.

    Yan GZ, Brouwer KL, Pollack GM, Wang MZ, Tidwell RR, Hall JE, Paine MF.

    J Pharmacol Exp Ther. 2011 May;337(2):503-12. Epub 2011 Feb 14.

    PMID:
    21320872
    [PubMed - indexed for MEDLINE]
    Free PMC Article
    6.

    A novel tropically stable oral amphotericin B formulation (iCo-010) exhibits efficacy against visceral Leishmaniasis in a murine model.

    Wasan EK, Gershkovich P, Zhao J, Zhu X, Werbovetz K, Tidwell RR, Clement JG, Thornton SJ, Wasan KM.

    PLoS Negl Trop Dis. 2010 Dec 7;4(12):e913.

    PMID:
    21151883
    [PubMed - indexed for MEDLINE]
    Free PMC Article
    7.

    Synthesis and antitrypanosomal evaluation of derivatives of N-benzyl-1,2-dihydroquinolin-6-ols: Effect of core substitutions and salt formation.

    Reid CS, Patrick DA, He S, Fotie J, Premalatha K, Tidwell RR, Wang MZ, Liu Q, Gershkovich P, Wasan KM, Wenzler T, Brun R, Werbovetz KA.

    Bioorg Med Chem. 2011 Jan 1;19(1):513-23. Epub 2010 Nov 5.

    PMID:
    21112788
    [PubMed - indexed for MEDLINE]
    8.

    Pharmacophore model for pentamidine analogs active against Plasmodium falciparum.

    Athri P, Wenzler T, Tidwell R, Bakunova SM, Wilson WD.

    Eur J Med Chem. 2010 Dec;45(12):6147-51. Epub 2010 Sep 18.

    PMID:
    20884090
    [PubMed - indexed for MEDLINE]
    9.

    Diamidines for human African trypanosomiasis.

    Paine MF, Wang MZ, Generaux CN, Boykin DW, Wilson WD, De Koning HP, Olson CA, Pohlig G, Burri C, Brun R, Murilla GA, Thuita JK, Barrett MP, Tidwell RR.

    Curr Opin Investig Drugs. 2010 Aug;11(8):876-83. Review.

    PMID:
    20721830
    [PubMed - indexed for MEDLINE]
    10.

    The biological in vitro effect and selectivity of aromatic dicationic compounds on Trypanosoma cruzi.

    da Silva CF, da Silva PB, Batista MM, Daliry A, Tidwell RR, Soeiro Mde N.

    Mem Inst Oswaldo Cruz. 2010 May;105(3):239-45.

    PMID:
    20512235
    [PubMed - indexed for MEDLINE]
    Free Article
    11.

    Application of monoclonal antibodies to measure metabolism of an anti-trypanosomal compound in vitro and in vivo.

    Goldsmith RB, Gray DR, Yan Z, Generaux CN, Tidwell RR, Reisner HM.

    J Clin Lab Anal. 2010;24(3):187-94. Erratum in: J Clin Lab Anal. 2011;25(4):309.

    PMID:
    20486201
    [PubMed - indexed for MEDLINE]
    12.

    Novel arylimidamides for treatment of visceral leishmaniasis.

    Wang MZ, Zhu X, Srivastava A, Liu Q, Sweat JM, Pandharkar T, Stephens CE, Riccio E, Parman T, Munde M, Mandal S, Madhubala R, Tidwell RR, Wilson WD, Boykin DW, Hall JE, Kyle DE, Werbovetz KA.

    Antimicrob Agents Chemother. 2010 Jun;54(6):2507-16. Epub 2010 Apr 5.

    PMID:
    20368397
    [PubMed - indexed for MEDLINE]
    Free PMC Article
    13.

    In vitro activity and preliminary toxicity of various diamidine compounds against Trypanosoma evansi.

    Gillingwater K, Kumar A, Ismail MA, Arafa RK, Stephens CE, Boykin DW, Tidwell RR, Brun R.

    Vet Parasitol. 2010 May 11;169(3-4):264-72. Epub 2010 Jan 25.

    PMID:
    20149544
    [PubMed - indexed for MEDLINE]
    14.

    Visceral leishmaniasis affects liver and spleen concentrations of amphotericin B following administration to mice.

    Gershkovich P, Wasan EK, Sivak O, Li R, Zhu X, Werbovetz KA, Tidwell RR, Clement JG, Thornton SJ, Wasan KM.

    J Antimicrob Chemother. 2010 Mar;65(3):535-7. Epub 2009 Dec 21.

    PMID:
    20026611
    [PubMed - indexed for MEDLINE]
    Free Article
    15.

    Synthesis and antiprotozoal activity of cationic 1,4-diphenyl-1H-1,2,3-triazoles.

    Bakunov SA, Bakunova SM, Wenzler T, Ghebru M, Werbovetz KA, Brun R, Tidwell RR.

    J Med Chem. 2010 Jan 14;53(1):254-72. Erratum in: J Med Chem. 2011 Jun 23;54(12):4281.

    PMID:
    19928900
    [PubMed - indexed for MEDLINE]
    Free PMC Article
    16.

    Surveillance for antibodies to Leishmania spp. in dogs from Sri Lanka.

    Rosypal AC, Tripp S, Kinlaw C, Hailemariam S, Tidwell RR, Lindsay DS, Rajapakse RP, Sreekumar C, Dubey JP.

    J Parasitol. 2010 Feb;96(1):230-1.

    PMID:
    19803542
    [PubMed - indexed for MEDLINE]
    17.

    In vivo investigations of selected diamidine compounds against Trypanosoma evansi using a mouse model.

    Gillingwater K, Kumar A, Anbazhagan M, Boykin DW, Tidwell RR, Brun R.

    Antimicrob Agents Chemother. 2009 Dec;53(12):5074-9. Epub 2009 Sep 28.

    PMID:
    19786604
    [PubMed - indexed for MEDLINE]
    Free PMC Article
    18.

    Synthesis and antiprotozoal properties of pentamidine congeners bearing the benzofuran motif.

    Bakunov SA, Bakunova SM, Bridges AS, Wenzler T, Barszcz T, Werbovetz KA, Brun R, Tidwell RR.

    J Med Chem. 2009 Sep 24;52(18):5763-7.

    PMID:
    19757840
    [PubMed - indexed for MEDLINE]
    19.

    In vitro analyses of the effect of aromatic diamidines upon Trypanosoma cruzi.

    Daliry A, Da Silva PB, Da Silva CF, Batista MM, De Castro SL, Tidwell RR, Soeiro Mde N.

    J Antimicrob Chemother. 2009 Oct;64(4):747-50. Epub 2009 Aug 11.

    PMID:
    19671588
    [PubMed - indexed for MEDLINE]
    Free Article
    20.

    New treatment option for second-stage African sleeping sickness: in vitro and in vivo efficacy of aza analogs of DB289.

    Wenzler T, Boykin DW, Ismail MA, Hall JE, Tidwell RR, Brun R.

    Antimicrob Agents Chemother. 2009 Oct;53(10):4185-92. Epub 2009 Jul 20.

    PMID:
    19620327
    [PubMed - indexed for MEDLINE]
    Free PMC Article

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