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Results: 1 to 20 of 348


SurvCurv database and online survival analysis platform update.

Ziehm M, Ivanov DK, Bhat A, Partridge L, Thornton JM.

Bioinformatics. 2015 Aug 6. pii: btv463. [Epub ahead of print]


The Classification and Evolution of Enzyme Function.

Martínez Cuesta S, Rahman SA, Furnham N, Thornton JM.

Biophys J. 2015 May 15. pii: S0006-3495(15)00400-2. doi: 10.1016/j.bpj.2015.04.020. [Epub ahead of print] Review.


Longevity GWAS Using the Drosophila Genetic Reference Panel.

Ivanov DK, Escott-Price V, Ziehm M, Magwire MM, Mackay TF, Partridge L, Thornton JM.

J Gerontol A Biol Sci Med Sci. 2015 Apr 28. pii: glv047. [Epub ahead of print]


Endovascular treatment for Small Core and Anterior circulation Proximal occlusion with Emphasis on minimizing CT to recanalization times (ESCAPE) trial: methodology.

Demchuk AM, Goyal M, Menon BK, Eesa M, Ryckborst KJ, Kamal N, Patil S, Mishra S, Almekhlafi M, Randhawa PA, Roy D, Willinsky R, Montanera W, Silver FL, Shuaib A, Rempel J, Jovin T, Frei D, Sapkota B, Thornton JM, Poppe A, Tampieri D, Lum C, Weill A, Sajobi TT, Hill MD; ESCAPE Trial Investigators.

Int J Stroke. 2015 Apr;10(3):429-38. doi: 10.1111/ijs.12424. Epub 2014 Dec 25.


Comparison of the mammalian insulin signalling pathway to invertebrates in the context of FOXO-mediated ageing.

Papatheodorou I, Petrovs R, Thornton JM.

Bioinformatics. 2014 Nov 1;30(21):2999-3003. doi: 10.1093/bioinformatics/btu493. Epub 2014 Jul 26.


The evolution of enzyme function in the isomerases.

Martinez Cuesta S, Furnham N, Rahman SA, Sillitoe I, Thornton JM.

Curr Opin Struct Biol. 2014 Jun;26:121-30. doi: 10.1016/ Epub 2014 Jul 5. Review.


Exploring the biological and chemical complexity of the ligases.

Holliday GL, Rahman SA, Furnham N, Thornton JM.

J Mol Biol. 2014 May 15;426(10):2098-111. doi: 10.1016/j.jmb.2014.03.008. Epub 2014 Mar 21. Review.


MDL-1, a growth- and tumor-suppressor, slows aging and prevents germline hyperplasia and hypertrophy in C. elegans.

Riesen M, Feyst I, Rattanavirotkul N, Ezcurra M, Tullet JM, Papatheodorou I, Ziehm M, Au C, Gilliat AF, Hellberg J, Thornton JM, Gems D.

Aging (Albany NY). 2014 Feb;6(2):98-117.


DAF-16/FoxO directly regulates an atypical AMP-activated protein kinase gamma isoform to mediate the effects of insulin/IGF-1 signaling on aging in Caenorhabditis elegans.

Tullet JM, Araiz C, Sanders MJ, Au C, Benedetto A, Papatheodorou I, Clark E, Schmeisser K, Jones D, Schuster EF, Thornton JM, Gems D.

PLoS Genet. 2014 Feb 6;10(2):e1004109. doi: 10.1371/journal.pgen.1004109. eCollection 2014 Feb.


EC-BLAST: a tool to automatically search and compare enzyme reactions.

Rahman SA, Cuesta SM, Furnham N, Holliday GL, Thornton JM.

Nat Methods. 2014 Feb;11(2):171-4. doi: 10.1038/nmeth.2803. Epub 2014 Jan 12.


Amino acid changes in disease-associated variants differ radically from variants observed in the 1000 genomes project dataset.

de Beer TA, Laskowski RA, Parks SL, Sipos B, Goldman N, Thornton JM.

PLoS Comput Biol. 2013;9(12):e1003382. doi: 10.1371/journal.pcbi.1003382. Epub 2013 Dec 12.


The Catalytic Site Atlas 2.0: cataloging catalytic sites and residues identified in enzymes.

Furnham N, Holliday GL, de Beer TA, Jacobsen JO, Pearson WR, Thornton JM.

Nucleic Acids Res. 2014 Jan;42(Database issue):D485-9. doi: 10.1093/nar/gkt1243. Epub 2013 Dec 6.


LigSearch: a knowledge-based web server to identify likely ligands for a protein target.

de Beer TA, Laskowski RA, Duban ME, Chan AW, Anderson WF, Thornton JM.

Acta Crystallogr D Biol Crystallogr. 2013 Dec;69(Pt 12):2395-402. doi: 10.1107/S0907444913022294. Epub 2013 Nov 19.


PDBsum additions.

de Beer TA, Berka K, Thornton JM, Laskowski RA.

Nucleic Acids Res. 2014 Jan;42(Database issue):D292-6. doi: 10.1093/nar/gkt940. Epub 2013 Oct 22.


Unlocking the potential of survival data for model organisms through a new database and online analysis platform: SurvCurv.

Ziehm M, Thornton JM.

Aging Cell. 2013 Oct;12(5):910-6. doi: 10.1111/acel.12121. Epub 2013 Jul 22.


Analysing variation in Drosophila aging across independent experimental studies: a meta-analysis of survival data.

Ziehm M, Piper MD, Thornton JM.

Aging Cell. 2013 Oct;12(5):917-22. doi: 10.1111/acel.12123. Epub 2013 Jul 22.


Transcriptional feedback in the insulin signalling pathway modulates ageing in both Caenorhabditis elegans and Drosophila melanogaster.

Ivanov DK, Papatheodorou I, Ziehm M, Thornton JM.

Mol Biosyst. 2013 Jul;9(7):1756-64. doi: 10.1039/c3mb25485b. Epub 2013 Apr 26.


Using answer set programming to integrate RNA expression with signalling pathway information to infer how mutations affect ageing.

Papatheodorou I, Ziehm M, Wieser D, Alic N, Partridge L, Thornton JM.

PLoS One. 2012;7(12):e50881. doi: 10.1371/journal.pone.0050881. Epub 2012 Dec 10.


New functional families (FunFams) in CATH to improve the mapping of conserved functional sites to 3D structures.

Sillitoe I, Cuff AL, Dessailly BH, Dawson NL, Furnham N, Lee D, Lees JG, Lewis TE, Studer RA, Rentzsch R, Yeats C, Thornton JM, Orengo CA.

Nucleic Acids Res. 2013 Jan;41(Database issue):D490-8. doi: 10.1093/nar/gks1211. Epub 2012 Nov 29.


The EBI enzyme portal.

Alcántara R, Onwubiko J, Cao H, Matos Pd, Cham JA, Jacobsen J, Holliday GL, Fischer JD, Rahman SA, Jassal B, Goujon M, Rowland F, Velankar S, López R, Overington JP, Kleywegt GJ, Hermjakob H, O'Donovan C, Martín MJ, Thornton JM, Steinbeck C.

Nucleic Acids Res. 2013 Jan;41(Database issue):D773-80. doi: 10.1093/nar/gks1112. Epub 2012 Nov 21.

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