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Results: 1 to 20 of 110

1.

Inhibiting protein arginine deiminases has anti-oxidant consequences.

Witalison EE, Cui X, Hofseth AB, Subramanian V, Causey CP, Thompson PR, Hofseth LJ.

J Pharmacol Exp Ther. 2015 Jan 29. pii: jpet.115.222745. [Epub ahead of print]

PMID:
25635139
[PubMed - as supplied by publisher]
2.

Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation.

Lewis HD, Liddle J, Coote JE, Atkinson SJ, Barker MD, Bax BD, Bicker KL, Bingham RP, Campbell M, Chen YH, Chung CW, Craggs PD, Davis RP, Eberhard D, Joberty G, Lind KE, Locke K, Maller C, Martinod K, Patten C, Polyakova O, Rise CE, RĂ¼diger M, Sheppard RJ, Slade DJ, Thomas P, Thorpe J, Yao G, Drewes G, Wagner DD, Thompson PR, Prinjha RK, Wilson DM.

Nat Chem Biol. 2015 Jan 26. doi: 10.1038/nchembio.1735. [Epub ahead of print]

PMID:
25622091
[PubMed - as supplied by publisher]
3.

Protein Arginine Deiminase 2 Binds Calcium in an Ordered Fashion: Implications for Inhibitor Design.

Slade DJ, Fang P, Dreyton CJ, Zhang Y, Fuhrmann J, Rempel D, Bax BD, Coonrod SA, Lewis HD, Guo M, Gross ML, Thompson PR.

ACS Chem Biol. 2015 Jan 26. [Epub ahead of print]

PMID:
25621824
[PubMed - as supplied by publisher]
4.

Design, Synthesis, and Biological Evaluation of Tetrazole Analogs of Cl-Amidine as Protein Arginine Deiminase Inhibitors.

Subramanian V, Knight JS, Parelkar S, Anguish L, Coonrod SA, Kaplan MJ, Thompson PR.

J Med Chem. 2015 Jan 16. [Epub ahead of print]

PMID:
25559347
[PubMed - as supplied by publisher]
5.

Protein arginine methyltransferase 5 catalyzes substrate dimethylation in a distributive fashion.

Wang M, Fuhrmann J, Thompson PR.

Biochemistry. 2014 Dec 23;53(50):7884-92. doi: 10.1021/bi501279g. Epub 2014 Dec 8.

PMID:
25485739
[PubMed - in process]
6.

Peptidylarginine deiminase inhibition disrupts NET formation and protects against kidney, skin and vascular disease in lupus-prone MRL/lpr mice.

Knight JS, Subramanian V, O'Dell AA, Yalavarthi S, Zhao W, Smith CK, Hodgin JB, Thompson PR, Kaplan MJ.

Ann Rheum Dis. 2014 Aug 7. pii: annrheumdis-2014-205365. doi: 10.1136/annrheumdis-2014-205365. [Epub ahead of print]

PMID:
25104775
[PubMed - as supplied by publisher]
7.

Mechanistic studies of protein arginine deiminase 2: evidence for a substrate-assisted mechanism.

Dreyton CJ, Knuckley B, Jones JE, Lewallen DM, Thompson PR.

Biochemistry. 2014 Jul 15;53(27):4426-33. doi: 10.1021/bi500554b. Epub 2014 Jul 3.

PMID:
24989433
[PubMed - indexed for MEDLINE]
8.

A novel role for protein arginine deiminase 4 in pluripotency: the emerging role of citrullinated histone H1 in cellular programming.

Slade DJ, Horibata S, Coonrod SA, Thompson PR.

Bioessays. 2014 Aug;36(8):736-40. doi: 10.1002/bies.201400057. Epub 2014 May 30.

PMID:
24889365
[PubMed - in process]
9.

Neutrophil extracellular trap-derived enzymes oxidize high-density lipoprotein: an additional proatherogenic mechanism in systemic lupus erythematosus.

Smith CK, Vivekanandan-Giri A, Tang C, Knight JS, Mathew A, Padilla RL, Gillespie BW, Carmona-Rivera C, Liu X, Subramanian V, Hasni S, Thompson PR, Heinecke JW, Saran R, Pennathur S, Kaplan MJ.

Arthritis Rheumatol. 2014 Sep;66(9):2532-44. doi: 10.1002/art.38703.

PMID:
24838349
[PubMed - indexed for MEDLINE]
10.

Peptidylarginine deiminases: novel drug targets for prevention of neuronal damage following hypoxic ischemic insult (HI) in neonates.

Lange S, Rocha-Ferreira E, Thei L, Mawjee P, Bennett K, Thompson PR, Subramanian V, Nicholas AP, Peebles D, Hristova M, Raivich G.

J Neurochem. 2014 Aug;130(4):555-62. doi: 10.1111/jnc.12744. Epub 2014 May 24.

PMID:
24762056
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Pluripotency: citrullination unravels stem cells.

Slade DJ, Subramanian V, Thompson PR.

Nat Chem Biol. 2014 May;10(5):327-8. doi: 10.1038/nchembio.1504. No abstract available.

PMID:
24743255
[PubMed - indexed for MEDLINE]
12.

Deimination of linker histones links neutrophil extracellular trap release with autoantibodies in systemic autoimmunity.

Dwivedi N, Neeli I, Schall N, Wan H, Desiderio DM, Csernok E, Thompson PR, Dali H, Briand JP, Muller S, Radic M.

FASEB J. 2014 Jul;28(7):2840-51. doi: 10.1096/fj.13-247254. Epub 2014 Mar 26.

PMID:
24671707
[PubMed - indexed for MEDLINE]
13.

Modulation of calcium-induced cell death in human neural stem cells by the novel peptidylarginine deiminase-AIF pathway.

U KP, Subramanian V, Nicholas AP, Thompson PR, Ferretti P.

Biochim Biophys Acta. 2014 Jun;1843(6):1162-71. doi: 10.1016/j.bbamcr.2014.02.018. Epub 2014 Mar 5.

PMID:
24607566
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

A FluoPol-ABPP PAD2 high-throughput screen identifies the first calcium site inhibitor targeting the PADs.

Lewallen DM, Bicker KL, Madoux F, Chase P, Anguish L, Coonrod S, Hodder P, Thompson PR.

ACS Chem Biol. 2014 Apr 18;9(4):913-21. doi: 10.1021/cb400841k. Epub 2014 Jan 27.

PMID:
24467619
[PubMed - in process]
Free PMC Article
15.

Insights into the mechanism of streptonigrin-induced protein arginine deiminase inactivation.

Dreyton CJ, Anderson ED, Subramanian V, Boger DL, Thompson PR.

Bioorg Med Chem. 2014 Feb 15;22(4):1362-9. doi: 10.1016/j.bmc.2013.12.064. Epub 2014 Jan 8.

PMID:
24440480
[PubMed - indexed for MEDLINE]
16.

Peptidylarginine deiminase inhibition reduces vascular damage and modulates innate immune responses in murine models of atherosclerosis.

Knight JS, Luo W, O'Dell AA, Yalavarthi S, Zhao W, Subramanian V, Guo C, Grenn RC, Thompson PR, Eitzman DT, Kaplan MJ.

Circ Res. 2014 Mar 14;114(6):947-56. doi: 10.1161/CIRCRESAHA.114.303312. Epub 2014 Jan 14.

PMID:
24425713
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Using unnatural amino acid mutagenesis to probe the regulation of PRMT1.

Rust HL, Subramanian V, West GM, Young DD, Schultz PG, Thompson PR.

ACS Chem Biol. 2014 Mar 21;9(3):649-55. doi: 10.1021/cb400859z. Epub 2014 Jan 6.

PMID:
24358983
[PubMed - indexed for MEDLINE]
18.

Inhibiting AMPylation: a novel screen to identify the first small molecule inhibitors of protein AMPylation.

Lewallen DM, Sreelatha A, Dharmarajan V, Madoux F, Chase P, Griffin PR, Orth K, Hodder P, Thompson PR.

ACS Chem Biol. 2014 Feb 21;9(2):433-42. doi: 10.1021/cb4006886. Epub 2013 Nov 25.

PMID:
24274060
[PubMed - indexed for MEDLINE]
19.

Automethylation of protein arginine methyltransferase 8 (PRMT8) regulates activity by impeding S-adenosylmethionine sensitivity.

Dillon MB, Rust HL, Thompson PR, Mowen KA.

J Biol Chem. 2013 Sep 27;288(39):27872-80. doi: 10.1074/jbc.M113.491092. Epub 2013 Aug 14.

PMID:
23946480
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Substrate specificity, processivity, and kinetic mechanism of protein arginine methyltransferase 5.

Wang M, Xu RM, Thompson PR.

Biochemistry. 2013 Aug 13;52(32):5430-40. doi: 10.1021/bi4005123. Epub 2013 Aug 1.

PMID:
23866019
[PubMed - indexed for MEDLINE]

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