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Results: 1 to 20 of 105

1.

Peptidylarginine deiminase inhibition disrupts NET formation and protects against kidney, skin and vascular disease in lupus-prone MRL/lpr mice.

Knight JS, Subramanian V, O'Dell AA, Yalavarthi S, Zhao W, Smith CK, Hodgin JB, Thompson PR, Kaplan MJ.

Ann Rheum Dis. 2014 Aug 7. pii: annrheumdis-2014-205365. doi: 10.1136/annrheumdis-2014-205365. [Epub ahead of print]

PMID:
25104775
[PubMed - as supplied by publisher]
2.

Mechanistic studies of protein arginine deiminase 2: evidence for a substrate-assisted mechanism.

Dreyton CJ, Knuckley B, Jones JE, Lewallen DM, Thompson PR.

Biochemistry. 2014 Jul 15;53(27):4426-33. doi: 10.1021/bi500554b. Epub 2014 Jul 3.

PMID:
24989433
[PubMed - indexed for MEDLINE]
3.

A novel role for protein arginine deiminase 4 in pluripotency: the emerging role of citrullinated histone H1 in cellular programming.

Slade DJ, Horibata S, Coonrod SA, Thompson PR.

Bioessays. 2014 Aug;36(8):736-40. doi: 10.1002/bies.201400057. Epub 2014 May 30.

PMID:
24889365
[PubMed - in process]
4.

Neutrophil extracellular trap-derived enzymes oxidize high-density lipoprotein: an additional proatherogenic mechanism in systemic lupus erythematosus.

Smith CK, Vivekanandan-Giri A, Tang C, Knight JS, Mathew A, Padilla RL, Gillespie BW, Carmona-Rivera C, Liu X, Subramanian V, Hasni S, Thompson PR, Heinecke JW, Saran R, Pennathur S, Kaplan MJ.

Arthritis Rheumatol. 2014 Sep;66(9):2532-44. doi: 10.1002/art.38703.

PMID:
24838349
[PubMed - in process]
5.

Peptidylarginine deiminases: novel drug targets for prevention of neuronal damage following hypoxic ischemic insult (HI) in neonates.

Lange S, Rocha-Ferreira E, Thei L, Mawjee P, Bennett K, Thompson PR, Subramanian V, Nicholas AP, Peebles D, Hristova M, Raivich G.

J Neurochem. 2014 Aug;130(4):555-62. doi: 10.1111/jnc.12744. Epub 2014 May 24.

PMID:
24762056
[PubMed - in process]
6.

Pluripotency: citrullination unravels stem cells.

Slade DJ, Subramanian V, Thompson PR.

Nat Chem Biol. 2014 May;10(5):327-8. doi: 10.1038/nchembio.1504. No abstract available.

PMID:
24743255
[PubMed - indexed for MEDLINE]
7.

Deimination of linker histones links neutrophil extracellular trap release with autoantibodies in systemic autoimmunity.

Dwivedi N, Neeli I, Schall N, Wan H, Desiderio DM, Csernok E, Thompson PR, Dali H, Briand JP, Muller S, Radic M.

FASEB J. 2014 Jul;28(7):2840-51. doi: 10.1096/fj.13-247254. Epub 2014 Mar 26.

PMID:
24671707
[PubMed - in process]
8.

Modulation of calcium-induced cell death in human neural stem cells by the novel peptidylarginine deiminase-AIF pathway.

U KP, Subramanian V, Nicholas AP, Thompson PR, Ferretti P.

Biochim Biophys Acta. 2014 Jun;1843(6):1162-71. doi: 10.1016/j.bbamcr.2014.02.018. Epub 2014 Mar 5.

PMID:
24607566
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

A FluoPol-ABPP PAD2 high-throughput screen identifies the first calcium site inhibitor targeting the PADs.

Lewallen DM, Bicker KL, Madoux F, Chase P, Anguish L, Coonrod S, Hodder P, Thompson PR.

ACS Chem Biol. 2014 Apr 18;9(4):913-21. doi: 10.1021/cb400841k. Epub 2014 Jan 27.

PMID:
24467619
[PubMed - in process]
10.

Insights into the mechanism of streptonigrin-induced protein arginine deiminase inactivation.

Dreyton CJ, Anderson ED, Subramanian V, Boger DL, Thompson PR.

Bioorg Med Chem. 2014 Feb 15;22(4):1362-9. doi: 10.1016/j.bmc.2013.12.064. Epub 2014 Jan 8.

PMID:
24440480
[PubMed - in process]
11.

Peptidylarginine deiminase inhibition reduces vascular damage and modulates innate immune responses in murine models of atherosclerosis.

Knight JS, Luo W, O'Dell AA, Yalavarthi S, Zhao W, Subramanian V, Guo C, Grenn RC, Thompson PR, Eitzman DT, Kaplan MJ.

Circ Res. 2014 Mar 14;114(6):947-56. doi: 10.1161/CIRCRESAHA.114.303312. Epub 2014 Jan 14.

PMID:
24425713
[PubMed - indexed for MEDLINE]
12.

Using unnatural amino acid mutagenesis to probe the regulation of PRMT1.

Rust HL, Subramanian V, West GM, Young DD, Schultz PG, Thompson PR.

ACS Chem Biol. 2014 Mar 21;9(3):649-55. doi: 10.1021/cb400859z. Epub 2014 Jan 6.

PMID:
24358983
[PubMed - in process]
13.

Inhibiting AMPylation: a novel screen to identify the first small molecule inhibitors of protein AMPylation.

Lewallen DM, Sreelatha A, Dharmarajan V, Madoux F, Chase P, Griffin PR, Orth K, Hodder P, Thompson PR.

ACS Chem Biol. 2014 Feb 21;9(2):433-42. doi: 10.1021/cb4006886. Epub 2013 Nov 25.

PMID:
24274060
[PubMed - in process]
14.

Automethylation of protein arginine methyltransferase 8 (PRMT8) regulates activity by impeding S-adenosylmethionine sensitivity.

Dillon MB, Rust HL, Thompson PR, Mowen KA.

J Biol Chem. 2013 Sep 27;288(39):27872-80. doi: 10.1074/jbc.M113.491092. Epub 2013 Aug 14.

PMID:
23946480
[PubMed - indexed for MEDLINE]
15.

Substrate specificity, processivity, and kinetic mechanism of protein arginine methyltransferase 5.

Wang M, Xu RM, Thompson PR.

Biochemistry. 2013 Aug 13;52(32):5430-40. doi: 10.1021/bi4005123. Epub 2013 Aug 1.

PMID:
23866019
[PubMed - indexed for MEDLINE]
16.

Targeting the arginine phosphatase YwlE with a catalytic redox-based inhibitor.

Fuhrmann J, Subramanian V, Thompson PR.

ACS Chem Biol. 2013 Sep 20;8(9):2024-32. doi: 10.1021/cb4001469. Epub 2013 Jul 9.

PMID:
23838530
[PubMed - indexed for MEDLINE]
17.

Peptidylarginine deiminase inhibition is immunomodulatory and vasculoprotective in murine lupus.

Knight JS, Zhao W, Luo W, Subramanian V, O'Dell AA, Yalavarthi S, Hodgin JB, Eitzman DT, Thompson PR, Kaplan MJ.

J Clin Invest. 2013 Jul 1;123(7):2981-93. doi: 10.1172/JCI67390. Epub 2013 Jun 3.

PMID:
23722903
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Chemical and biological methods to detect post-translational modifications of arginine.

Slade DJ, Subramanian V, Fuhrmann J, Thompson PR.

Biopolymers. 2014 Feb;101(2):133-43. doi: 10.1002/bip.22256.

PMID:
23576281
[PubMed - in process]
19.

Design, synthesis, and kinetic characterization of protein N-terminal acetyltransferase inhibitors.

Foyn H, Jones JE, Lewallen D, Narawane R, Varhaug JE, Thompson PR, Arnesen T.

ACS Chem Biol. 2013;8(6):1121-7. doi: 10.1021/cb400136s. Epub 2013 Apr 4.

PMID:
23557624
[PubMed - indexed for MEDLINE]
20.

D-amino acid based protein arginine deiminase inhibitors: Synthesis, pharmacokinetics, and in cellulo efficacy.

Bicker KL, Anguish L, Chumanevich AA, Cameron MD, Cui X, Witalison E, Subramanian V, Zhang X, Chumanevich AP, Hofseth LJ, Coonrod SA, Thompson PR.

ACS Med Chem Lett. 2012 Oct 26;3(12):1081-1085.

PMID:
23420624
[PubMed]
Free PMC Article

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