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The investigation of resveratrol and analogs as potential inducers of fetal hemoglobin.

Theodorou A, Phylactides M, Forti L, Cramarossa MR, Spyrou P, Gambari R, Thein SL, Kleanthous M.

Blood Cells Mol Dis. 2016 May;58:6-12. doi: 10.1016/j.bcmd.2015.11.007. Epub 2015 Dec 1.


Alpha-thalassaemia trait as a cause of unexplained microcytosis in a South African population.

Loonat SB, Naran NH, Thein SL, Alli NA.

S Afr Med J. 2016 Feb 22;106(3):276-9. doi: 10.7196/SAMJ.2016.v106i3.10005.


Reduced rate of sickle-related complications in Brazilian patients carrying HbF-promoting alleles at the BCL11A and HMIP-2 loci.

Leonardo FC, Brugnerotto AF, Domingos IF, Fertrin KY, de Albuquerque DM, Bezerra MA, Araújo AS, Saad ST, Costa FF, Menzel S, Conran N, Thein SL.

Br J Haematol. 2016 May;173(3):456-60. doi: 10.1111/bjh.13961. Epub 2016 Feb 16.


Longitudinal assessment of lung function in children with sickle cell disease.

Lunt A, McGhee E, Sylvester K, Rafferty G, Dick M, Rees D, Height S, Thein SL, Greenough A.

Pediatr Pulmonol. 2015 Dec 22. doi: 10.1002/ppul.23367. [Epub ahead of print]


Airway and alveolar nitric oxide production, lung function, and pulmonary blood flow in sickle cell disease.

Lunt A, Ahmed N, Rafferty GF, Dick M, Rees D, Height S, Thein SL, Greenough A.

Pediatr Res. 2016 Mar;79(2):313-7. doi: 10.1038/pr.2015.217. Epub 2015 Oct 22.


Venous thromboembolism in adults with sickle cell disease: experience of a single centre in the UK.

van Hamel Parsons V, Gardner K, Patel R, Thein SL.

Ann Hematol. 2015 Oct 21. [Epub ahead of print]


Tissue Iron Distribution Assessed by MRI in Patients with Iron Loading Anemias.

Gutiérrez L, House MJ, Vasavda N, Drašar E, Gonzalez-Gascon Y Marin I, Kulasekararaj AG, St Pierre TG, Thein SL.

PLoS One. 2015 Sep 25;10(9):e0139220. doi: 10.1371/journal.pone.0139220. eCollection 2015.


Genome-wide association analyses based on whole-genome sequencing in Sardinia provide insights into regulation of hemoglobin levels.

Danjou F, Zoledziewska M, Sidore C, Steri M, Busonero F, Maschio A, Mulas A, Perseu L, Barella S, Porcu E, Pistis G, Pitzalis M, Pala M, Menzel S, Metrustry S, Spector TD, Leoni L, Angius A, Uda M, Moi P, Thein SL, Galanello R, Abecasis GR, Schlessinger D, Sanna S, Cucca F.

Nat Genet. 2015 Nov;47(11):1264-71. doi: 10.1038/ng.3307. Epub 2015 Sep 14.


Prevention of Morbidity in sickle cell disease--qualitative outcomes, pain and quality of life in a randomised cross-over pilot trial of overnight supplementary oxygen and auto-adjusting continuous positive airways pressure (POMS2a): study protocol for a randomised controlled trial.

Howard J, Inusa B, Liossi C, Jacob E, Murphy PB, Hart N, Gavlak J, Sahota S, Chorozoglou M, Nwosu C, Gwam M, Gupta A, Rees DC, Thein SL, Reading IC, Kirkham FJ, Cheng MY.

Trials. 2015 Aug 25;16:376. doi: 10.1186/s13063-015-0883-y.


Pulmonary Haemodynamics in Sickle Cell Disease Are Driven Predominantly by a High-Output State Rather Than Elevated Pulmonary Vascular Resistance: A Prospective 3-Dimensional Echocardiography/Doppler Study.

Mushemi-Blake S, Melikian N, Drasar E, Bhan A, Lunt A, Desai SR, Greenough A, Monaghan MJ, Thein SL, Shah AM.

PLoS One. 2015 Aug 13;10(8):e0135472. doi: 10.1371/journal.pone.0135472. eCollection 2015.


Super-elevated LDH and thrombocytopenia are markers of a severe subtype of vaso-occlusive crisis in sickle cell disease.

Gardner K, Thein SL.

Am J Hematol. 2015 Oct;90(10):E206-7. doi: 10.1002/ajh.24126. Epub 2015 Sep 1. No abstract available.


Haemoglobin Variant Screening in Jamaica: Meeting Student's Request.

Mason K, Gibson F, Higgs D, Fisher C, Thein SL, Clark B, Kulozik A, Happich M, Serjeant B, Serjeant G.

Br J Haematol. 2016 Feb;172(4):634-6. doi: 10.1111/bjh.13531. Epub 2015 Jun 30. No abstract available.


How we treat delayed haemolytic transfusion reactions in patients with sickle cell disease.

Gardner K, Hoppe C, Mijovic A, Thein SL.

Br J Haematol. 2015 Sep;170(6):745-56. doi: 10.1111/bjh.13494. Epub 2015 May 13. Review.


Genetic association of fetal-hemoglobin levels in individuals with sickle cell disease in Tanzania maps to conserved regulatory elements within the MYB core enhancer.

Mtatiro SN, Mgaya J, Singh T, Mariki H, Rooks H, Soka D, Mmbando B, Thein SL, Barrett JC, Makani J, Cox SE, Menzel S.

BMC Med Genet. 2015 Feb 10;16:4. doi: 10.1186/s12881-015-0148-3.


Response to hydroxyurea among Kuwaiti patients with sickle cell disease and elevated baseline HbF levels.

Adekile A, Menzel S, Gupta R, Al-Sharida S, Farag A, Haider M, Akbulut N, Mustafa N, Thein SL.

Am J Hematol. 2015 Jul;90(7):E138-9. doi: 10.1002/ajh.24027. No abstract available.


Delayed haemolytic transfusion reaction in adults with sickle cell disease: a 5-year experience.

Vidler JB, Gardner K, Amenyah K, Mijovic A, Thein SL.

Br J Haematol. 2015 Jun;169(5):746-53. doi: 10.1111/bjh.13339. Epub 2015 Mar 5.


The clinical significance of K-Cl cotransport activity in red cells of patients with HbSC disease.

Rees DC, Thein SL, Osei A, Drasar E, Tewari S, Hannemann A, Gibson JS.

Haematologica. 2015 May;100(5):595-600. doi: 10.3324/haematol.2014.120402. Epub 2015 Mar 6.


Spectral domain optical coherence tomography in patients with sickle cell disease.

Mathew R, Bafiq R, Ramu J, Pearce E, Richardson M, Drasar E, Thein SL, Sivaprasad S.

Br J Ophthalmol. 2015 Jul;99(7):967-72. doi: 10.1136/bjophthalmol-2014-305532. Epub 2015 Jan 16.


First reported duplication of the entire beta globin gene cluster causing an unusual sickle cell trait phenotype.

Shooter C, Senior McKenzie T, Oakley M, Jacques T, Clark B, Thein SL.

Br J Haematol. 2015 Jul;170(1):128-31. doi: 10.1111/bjh.13274. Epub 2014 Dec 18. No abstract available.


Genome wide association study of fetal hemoglobin in sickle cell anemia in Tanzania.

Mtatiro SN, Singh T, Rooks H, Mgaya J, Mariki H, Soka D, Mmbando B, Msaki E, Kolder I, Thein SL, Menzel S, Cox SE, Makani J, Barrett JC.

PLoS One. 2014 Nov 5;9(11):e111464. doi: 10.1371/journal.pone.0111464. eCollection 2014.

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