The potentiating effect of growth hormone on follicle stimulation with human menopausal gonadotropin in a panhypopituitary patient

Fertil Steril. 1989 Aug;52(2):328-31. doi: 10.1016/s0015-0282(16)60864-6.

Abstract

A hypogonadotropic patient with primary pituitary insufficiency who has been previously treated for four cycles with hMG/hCG for ovulation induction is described. The hMG consumption was 76 to 96 ampules/cycle. Addition of GH (16 to 24 units/cycle) to hMG treatment was associated with a significant diminution in hMG consumption (35 to 36 ampules/cycle). The patient conceived on the second cycle of combined hMG/GH/hCG treatment. The possible role of GH as an adjunct to gonadotropin treatment is discussed, as well as the possible mechanisms of GH effects on the ovary.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Amenorrhea / complications
  • Chorionic Gonadotropin / therapeutic use
  • Drug Synergism
  • Female
  • Fertilization
  • Growth Hormone / therapeutic use*
  • Humans
  • Hypopituitarism / physiopathology*
  • Infertility, Female / drug therapy
  • Menotropins / therapeutic use*
  • Ovarian Follicle / physiopathology*
  • Stimulation, Chemical

Substances

  • Chorionic Gonadotropin
  • Menotropins
  • Growth Hormone