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2003 1
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2013 4
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2019 5
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The effects of imatinib on pregnancy outcome.
Pye SM, Cortes J, Ault P, Hatfield A, Kantarjian H, Pilot R, Rosti G, Apperley JF. Pye SM, et al. Blood. 2008 Jun 15;111(12):5505-8. doi: 10.1182/blood-2007-10-114900. Epub 2008 Mar 5. Blood. 2008. PMID: 18322153 Free PMC article.
Imatinib has now been in use for almost 10 years. Despite this cumulative experience, little is known about its effects on pregnancy; as a result, there are few published data to facilitate the counseling of women who conceive while taking imatinib. Th …
Imatinib has now been in use for almost 10 years. Despite this cumulative experience, little is known about its effects on …
Effects of chemotherapy during pregnancy on the placenta.
Abellar RG, Pepperell JR, Greco D, Gundogan F, Kostadinov S, Schwartz J, Tantravahi U, De Paepe ME. Abellar RG, et al. Pediatr Dev Pathol. 2009 Jan-Feb;12(1):35-41. doi: 10.2350/08-03-0435.1. Pediatr Dev Pathol. 2009. PMID: 18462010
Whereas the effects of chemotherapy during pregnancy for mother and fetus are well described, its effects on the placenta remain largely undetermined. ...Charts were reviewed for type of malignancy, type and timing of chemotherapy, and fetal and pregnancy …
Whereas the effects of chemotherapy during pregnancy for mother and fetus are well described, its effects on the placen …
Issues of imatinib and pregnancy outcome.
Apperley J. Apperley J. J Natl Compr Canc Netw. 2009 Nov;7(10):1050-8. doi: 10.6004/jnccn.2009.0069. J Natl Compr Canc Netw. 2009. PMID: 19930974 Review.
In contrast, data are less encouraging for children born to women exposed to imatinib during pregnancy. Although numbers are small, a disturbing cluster of rare congenital malformations has prevented imatinib from being recommended safely, particularly during …
In contrast, data are less encouraging for children born to women exposed to imatinib during pregnancy. Although numbers are s …
Pregnancy outcome in chronic myeloid leukemia patients on imatinib therapy.
Mukhopadhyay A, Dasgupta S, Kanti Ray U, Gharami F, Bose CK, Mukhopadhyay S. Mukhopadhyay A, et al. Ir J Med Sci. 2015 Mar;184(1):183-8. doi: 10.1007/s11845-014-1084-5. Epub 2014 Mar 4. Ir J Med Sci. 2015. PMID: 24590821
MATERIALS AND METHODS: We selected 22 CML cases of pregnancies and reported 9 accidental and 13 planned pregnancies that were on imatinib therapy. Willing female patients remaining in complete hematological, cytogenetic and major molecular responses for at least 2 years pl …
MATERIALS AND METHODS: We selected 22 CML cases of pregnancies and reported 9 accidental and 13 planned pregnancies that were on imatinib …
[Chronic Myelogenous Leukemia].
Hochhaus A, Eigendorff E, Ernst T. Hochhaus A, et al. Dtsch Med Wochenschr. 2018 Sep;143(18):1304-1310. doi: 10.1055/s-0043-121023. Epub 2018 Sep 10. Dtsch Med Wochenschr. 2018. PMID: 30199910 German.
The advent of tyrosine kinase inhibitors (TKI) has improved prognosis and outcome of patients with chronic myelogenous leukemia (CML) considerably. In comparison to imatinib, first line use of second generation inhibitors nilotinib, dasatinib and bosutinib lead to f …
The advent of tyrosine kinase inhibitors (TKI) has improved prognosis and outcome of patients with chronic myelogenous leukemia (CML) …
The effect of tyrosine kinase inhibitor interruption and interferon use on pregnancy outcomes and long-term disease control in chronic myeloid leukemia.
Lasica M, Willcox A, Burbury K, Ross DM, Branford S, Butler J, Filshie R, Januszewicz H, Joske D, Mills A, Simpson D, Tam C, Taylor K, Watson AM, Wolf M, Grigg A. Lasica M, et al. Leuk Lymphoma. 2019 Jul;60(7):1796-1802. doi: 10.1080/10428194.2018.1551533. Epub 2019 Jan 11. Leuk Lymphoma. 2019. PMID: 30632843
The management of CML in pregnancy is challenging with the need to balance disease control against potential teratogenic effects of TKI therapy. In this multi-center case-cohort study of 16 women in chronic phase, CML ceased TKI treatment pre- or post-conception dur …
The management of CML in pregnancy is challenging with the need to balance disease control against potential teratogenic effects …
The New ELN Recommendations for Treating CML.
Hehlmann R. Hehlmann R. J Clin Med. 2020 Nov 16;9(11):3671. doi: 10.3390/jcm9113671. J Clin Med. 2020. PMID: 33207600 Free PMC article. Review.
Four tyrosine kinase inhibitors (TKIs) have been approved for first-line therapy: imatinib, dasatinib, nilotinib, bosutinib. Unexpectedly, the outcome of long-term randomized trials has shown that faster response as achieved by higher doses of imatinib, im …
Four tyrosine kinase inhibitors (TKIs) have been approved for first-line therapy: imatinib, dasatinib, nilotinib, bosutinib. Unexpect …
Imatinib use during pregnancy and breast feeding: a case report and review of the literature.
Ali R, Ozkalemkas F, Kimya Y, Koksal N, Ozkocaman V, Gulten T, Yorulmaz H, Tunali A. Ali R, et al. Arch Gynecol Obstet. 2009 Aug;280(2):169-75. doi: 10.1007/s00404-008-0861-7. Epub 2008 Dec 13. Arch Gynecol Obstet. 2009. PMID: 19083009 Review.
MATERIALS AND METHODS: We describe the clinical presentation, course and outcome of one pregnant patient with CML who was treated with imatinib. ...The patient tolerated the drug well and achieved complete hematological and cytogenetic remission. There were no im …
MATERIALS AND METHODS: We describe the clinical presentation, course and outcome of one pregnant patient with CML who was treated wit …
The effect of imatinib mesylate on the contractility of isolated rabbit myometrial strips.
Hutchings G, Deprest J, Nilius B, Roskams T, De Ridder D. Hutchings G, et al. Gynecol Obstet Invest. 2006;62(2):79-83. doi: 10.1159/000092530. Epub 2006 Apr 3. Gynecol Obstet Invest. 2006. PMID: 16601347
No effect was seen at lower concentrations. No effect of imatinib on frequency or duration of contractions was observed at any of the concentrations studied. CONCLUSIONS: In isolated rabbit myometrium, acute inhibition of the c-kit receptor by imatinib …
No effect was seen at lower concentrations. No effect of imatinib on frequency or duration of contractions was observed …
Management of pregnant chronic myeloid leukemia patients.
Abruzzese E, Trawinska MM, de Fabritiis P, Baccarani M. Abruzzese E, et al. Expert Rev Hematol. 2016 Aug;9(8):781-91. doi: 10.1080/17474086.2016.1205479. Epub 2016 Jul 7. Expert Rev Hematol. 2016. PMID: 27352939 Review.
AREAS COVERED: Data published and informations acquired in terms of fertility, conception, pregnancy, pregnancy outcome and illness control for all the approved TKIs will be reviewed, as well as suggest how to manage a planned and/or unplanned pregnancy …
AREAS COVERED: Data published and informations acquired in terms of fertility, conception, pregnancy, pregnancy outcome …
52 results