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Nat Cell Biol. 2011 Sep 2;13(9):1016-23. doi: 10.1038/ncb2329.

The AMPK signalling pathway coordinates cell growth, autophagy and metabolism.

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  • 1Molecular & Cell Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA.

Abstract

One of the central regulators of cellular and organismal metabolism in eukaryotes is AMP-activated protein kinase (AMPK), which is activated when intracellular ATP production decreases. AMPK has critical roles in regulating growth and reprogramming metabolism, and has recently been connected to cellular processes such as autophagy and cell polarity. Here we review a number of recent breakthroughs in the mechanistic understanding of AMPK function, focusing on a number of newly identified downstream effectors of AMPK.

PMID:
21892142
[PubMed - indexed for MEDLINE]
PMCID:
PMC3249400
Free PMC Article

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