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Year Number of Results
1968 2
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1983 1
1984 2
1985 2
1986 3
1987 2
1988 1
1989 4
1990 1
1991 3
1992 6
1993 7
1994 6
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1996 11
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1998 10
1999 12
2000 15
2001 17
2002 23
2003 30
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2005 39
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2007 36
2008 58
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2013 54
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2022 41
2023 42
2024 17

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1,077 results

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Page 1
Ambruticins: tetrahydropyran ring formation and total synthesis.
Bowen JI, Wang L, Crump MP, Willis CL. Bowen JI, et al. Org Biomol Chem. 2021 Jul 21;19(28):6210-6215. doi: 10.1039/d1ob00883h. Org Biomol Chem. 2021. PMID: 34190301
Gene knockout experiments are in accord with the proposal that the tetrahydropyran ring of the ambruticins is formed via the AmbJ catalysed epoxidation of the unsaturated 3,5-dihydroxy acid, ambruticin J, followed by regioselective cyclisation to ambruticin F. Herein, a co …
Gene knockout experiments are in accord with the proposal that the tetrahydropyran ring of the ambruticins is formed via the AmbJ cat …
Contemporary Strategies for the Synthesis of Tetrahydropyran Derivatives: Application to Total Synthesis of Neopeltolide, a Marine Macrolide Natural Product.
Fuwa H. Fuwa H. Mar Drugs. 2016 Mar 25;14(4):65. doi: 10.3390/md14040065. Mar Drugs. 2016. PMID: 27023567 Free PMC article. Review.
Tetrahydropyrans are structural motifs that are abundantly present in a range of biologically important marine natural products. ...This review summarizes the total and formal syntheses of neopeltolide and its analogues, highlighting the synthetic strategies exploited for …
Tetrahydropyrans are structural motifs that are abundantly present in a range of biologically important marine natural products. ...T …
Strategies for the construction of tetrahydropyran rings in the synthesis of natural products.
Nasir NM, Ermanis K, Clarke PA. Nasir NM, et al. Org Biomol Chem. 2014 Jun 7;12(21):3323-35. doi: 10.1039/c4ob00423j. Epub 2014 Apr 17. Org Biomol Chem. 2014. PMID: 24744139 Review.
This review focuses on the methodology used for the construction of tetrahydropyran (THP) rings in the synthesis of natural products over the last seven years. ...
This review focuses on the methodology used for the construction of tetrahydropyran (THP) rings in the synthesis of natural products …
Syntheses of Tetrahydropyran Type 8,7'-Neolignans Using a Ring-Expansion Reaction and Tetrahydrofuran Type 8,7'-Neolignans to Discover a Novel Phytotoxic Neolignan.
Tanaka M, Nishiwaki H, Yamauchi S. Tanaka M, et al. J Agric Food Chem. 2023 Jun 14;71(23):9148-9156. doi: 10.1021/acs.jafc.3c01998. Epub 2023 May 30. J Agric Food Chem. 2023. PMID: 37253419
One novel tri-substituted tetrahydropyran type 8,7'-neolignan and its enantiomer with higher enantiomeric excess were synthesized from all cis-tetra-substituted tetrahydrofuran with an iodomethyl group by a hydride or H(2) ring-expansion reaction. ...The phytotoxicities of …
One novel tri-substituted tetrahydropyran type 8,7'-neolignan and its enantiomer with higher enantiomeric excess were synthesized fro …
Bisabolane-Type Sesquiterpenoids with a Tetrahydrofuran or Tetrahydropyran Ring from Vernonia solanifolia.
Li Z, Yang Y, Chen C, Lin L, Tang C, Ye Y. Li Z, et al. J Nat Prod. 2023 Jun 23;86(6):1550-1563. doi: 10.1021/acs.jnatprod.3c00253. Epub 2023 Jun 7. J Nat Prod. 2023. PMID: 37285406
Most compounds possess a rare tetrahydrofuran (1-17) or tetrahydropyran ring (18-21). Compounds 1/2 and 11/12 are pairs of epimers isomerized at C-10, while compounds 9/10 and 15/16 are isomerized at C-11 and C-2, respectively. ...
Most compounds possess a rare tetrahydrofuran (1-17) or tetrahydropyran ring (18-21). Compounds 1/2 and 11/12 are pairs of epimers is …
A Novel Trisubstituted Tetrahydropyran as a Possible Pheromone Component for the South American Cerambycid Beetle Macropophora accentifer.
Silva WD, Zou Y, Hanks LM, Bento JMS, Millar JG. Silva WD, et al. J Chem Ecol. 2022 Jun;48(5-6):569-582. doi: 10.1007/s10886-022-01362-6. Epub 2022 Apr 30. J Chem Ecol. 2022. PMID: 35501536
A novel trisubstituted tetrahydropyran was isolated and identified from the sex-specific volatiles produced by males of the cerambycid beetle Macropophora accentifer (Olivier), a serious pest of citrus and other fruit crops in South America. ...
A novel trisubstituted tetrahydropyran was isolated and identified from the sex-specific volatiles produced by males of the cerambyci …
Enantioselective access to tricyclic tetrahydropyran derivatives by a remote hydrogen bonding mediated intramolecular IEDHDA reaction.
Jin M, Tang C, Li Y, Yang S, Yang YT, Peng L, Li XN, Zhang W, Zuo Z, Gagosz F, Wang LL. Jin M, et al. Nat Commun. 2021 Dec 10;12(1):7188. doi: 10.1038/s41467-021-27521-z. Nat Commun. 2021. PMID: 34893616 Free PMC article.
Inverse-electron-demand-hetero-Diels-Alder reactions of alkenes with alpha,beta-unsaturated keto compounds allow rapid access to the tetrahydropyran ring found in numerous natural products and bioactive molecules. ...Herein, we describe the catalytic inverse-electron-deman …
Inverse-electron-demand-hetero-Diels-Alder reactions of alkenes with alpha,beta-unsaturated keto compounds allow rapid access to the tetr …
Direct synthesis of tetrahydropyran-4-ones via O(3)ReOH-catalyzed Prins cyclization of 3-chlorohomoallylic alcohols.
Tadpetch K, Vijitphan P, Kaewsen S, Thiraporn A, Rukachaisirikul V. Tadpetch K, et al. Org Biomol Chem. 2022 Dec 14;20(48):9618-9624. doi: 10.1039/d2ob01941h. Org Biomol Chem. 2022. PMID: 36420694
A new variation of Prins cyclization to directly and stereoselectively synthesize cis-2,6-disubstituted tetrahydropyran-4-ones from 3-chlorohomoallylic alcohols and aldehydes catalyzed by perrhenic acid is reported. The reaction is generally compatible with a range of alip …
A new variation of Prins cyclization to directly and stereoselectively synthesize cis-2,6-disubstituted tetrahydropyran-4-ones from 3 …
Tetrahydropyran- and tetrahydrofuran-containing diarylheptanoids from Hedychium coronarium rhizomes.
Lin YS, Lin JH, Chang CC, Lee SS. Lin YS, et al. J Nat Prod. 2015 Feb 27;78(2):181-7. doi: 10.1021/np500441r. Epub 2015 Jan 16. J Nat Prod. 2015. PMID: 25594362
Seven new diarylheptanoids (1-7) were isolated from the n-BuOH-soluble fraction of the rhizome of Hedychium coronarium. Hedycoropyrans A-C (1-3) contain a tetrahydropyran moiety, while hedycorofurans A-D (4-7) contain a tetrahydrofuran moiety, belonging to a rare structura …
Seven new diarylheptanoids (1-7) were isolated from the n-BuOH-soluble fraction of the rhizome of Hedychium coronarium. Hedycoropyrans A-C ( …
1,077 results