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DNA methylation outliers in normal breast tissue identify field defects that are enriched in cancer.

Teschendorff AE, Gao Y, Jones A, Ruebner M, Beckmann MW, Wachter DL, Fasching PA, Widschwendter M.

Nat Commun. 2016 Jan 29;7:10478. doi: 10.1038/ncomms10478.


The integrative epigenomic-transcriptomic landscape of ER positive breast cancer.

Gao Y, Jones A, Fasching PA, Ruebner M, Beckmann MW, Widschwendter M, Teschendorff AE.

Clin Epigenetics. 2015 Dec 9;7:126. doi: 10.1186/s13148-015-0159-0. eCollection 2015.


Glioblastoma Stem Cells Respond to Differentiation Cues but Fail to Undergo Commitment and Terminal Cell-Cycle Arrest.

Carén H, Stricker SH, Bulstrode H, Gagrica S, Johnstone E, Bartlett TE, Feber A, Wilson G, Teschendorff AE, Bertone P, Beck S, Pollard SM.

Stem Cell Reports. 2015 Oct 21. pii: S2213-6711(15)00276-3. doi: 10.1016/j.stemcr.2015.09.014. [Epub ahead of print]


HOTAIR and its surrogate DNA methylation signature indicate carboplatin resistance in ovarian cancer.

Teschendorff AE, Lee SH, Jones A, Fiegl H, Kalwa M, Wagner W, Chindera K, Evans I, Dubeau L, Orjalo A, Horlings HM, Niederreiter L, Kaser A, Yang W, Goode EL, Fridley BL, Jenner RG, Berns EM, Wik E, Salvesen HB, Wisman GB, van der Zee AG, Davidson B, Trope CG, Lambrechts S, Vergote I, Calvert H, Jacobs IJ, Widschwendter M.

Genome Med. 2015 Oct 24;7(1):108. doi: 10.1186/s13073-015-0233-4.


Variational Bayesian Matrix Factorization for Bounded Support Data.

Ma Z, Teschendorff AE, Leijon A, Qiao Y, Zhang H, Guo J.

IEEE Trans Pattern Anal Mach Intell. 2015 Apr;37(4):876-89. doi: 10.1109/TPAMI.2014.2353639.


Expression profiling of nuclear receptors in breast cancer identifies TLX as a mediator of growth and invasion in triple-negative breast cancer.

Lin ML, Patel H, Remenyi J, Banerji CR, Lai CF, Periyasamy M, Lombardo Y, Busonero C, Ottaviani S, Passey A, Quinlan PR, Purdie CA, Jordan LB, Thompson AM, Finn RS, Rueda OM, Caldas C, Gil J, Coombes RC, Fuller-Pace FV, Teschendorff AE, Buluwela L, Ali S.

Oncotarget. 2015 Aug 28;6(25):21685-703.


Correlation of Smoking-Associated DNA Methylation Changes in Buccal Cells With DNA Methylation Changes in Epithelial Cancer.

Teschendorff AE, Yang Z, Wong A, Pipinikas CP, Jiao Y, Jones A, Anjum S, Hardy R, Salvesen HB, Thirlwell C, Janes SM, Kuh D, Widschwendter M.

JAMA Oncol. 2015 Jul;1(4):476-85. doi: 10.1001/jamaoncol.2015.1053. Erratum in: JAMA Oncol. 2015 Jul;1(4):544.


An integrative pan-cancer-wide analysis of epigenetic enzymes reveals universal patterns of epigenomic deregulation in cancer.

Yang Z, Jones A, Widschwendter M, Teschendorff AE.

Genome Biol. 2015 Jul 14;16:140. doi: 10.1186/s13059-015-0699-9.


Increased signaling entropy in cancer requires the scale-free property of protein interaction networks.

Teschendorff AE, Banerji CR, Severini S, Kuehn R, Sollich P.

Sci Rep. 2015 Apr 28;5:9646. doi: 10.1038/srep09646.


Epigenetic dysregulation and poorer prognosis in DAXX-deficient pancreatic neuroendocrine tumours.

Pipinikas CP, Dibra H, Karpathakis A, Feber A, Novelli M, Oukrif D, Fusai G, Valente R, Caplin M, Meyer T, Teschendorff A, Bell C, Morris TJ, Salomoni P, Luong TV, Davidson B, Beck S, Thirlwell C.

Endocr Relat Cancer. 2015 Jun;22(3):L13-8. doi: 10.1530/ERC-15-0108. Epub 2015 Apr 21. No abstract available.


Intra-tumour signalling entropy determines clinical outcome in breast and lung cancer.

Banerji CR, Severini S, Caldas C, Teschendorff AE.

PLoS Comput Biol. 2015 Mar 20;11(3):e1004115. doi: 10.1371/journal.pcbi.1004115. eCollection 2015 Mar.


An integrative multi-scale analysis of the dynamic DNA methylation landscape in aging.

Yuan T, Jiao Y, de Jong S, Ophoff RA, Beck S, Teschendorff AE.

PLoS Genet. 2015 Feb 18;11(2):e1004996. doi: 10.1371/journal.pgen.1004996. eCollection 2015 Feb.


β-Catenin is central to DUX4-driven network rewiring in facioscapulohumeral muscular dystrophy.

Banerji CR, Knopp P, Moyle LA, Severini S, Orrell RW, Teschendorff AE, Zammit PS.

J R Soc Interface. 2015 Jan 6;12(102):20140797.


Biomedical data integration, modeling, and simulation in the era of big data and translational medicine.

Shen B, Teschendorff AE, Zhi D, Xia J.

Biomed Res Int. 2014;2014:731546. doi: 10.1155/2014/731546. Epub 2014 Jul 24. No abstract available.


A BRCA1-mutation associated DNA methylation signature in blood cells predicts sporadic breast cancer incidence and survival.

Anjum S, Fourkala EO, Zikan M, Wong A, Gentry-Maharaj A, Jones A, Hardy R, Cibula D, Kuh D, Jacobs IJ, Teschendorff AE, Menon U, Widschwendter M.

Genome Med. 2014 Jun 27;6(6):47. doi: 10.1186/gm567. eCollection 2014.


Data integration in the era of omics: current and future challenges.

Gomez-Cabrero D, Abugessaisa I, Maier D, Teschendorff A, Merkenschlager M, Gisel A, Ballestar E, Bongcam-Rudloff E, Conesa A, Tegnér J.

BMC Syst Biol. 2014;8 Suppl 2:I1. doi: 10.1186/1752-0509-8-S2-I1. Epub 2014 Mar 13. Review.


The dynamics of DNA methylation covariation patterns in carcinogenesis.

Teschendorff AE, Liu X, Caren H, Pollard SM, Beck S, Widschwendter M, Chen L.

PLoS Comput Biol. 2014 Jul 10;10(7):e1003709. doi: 10.1371/journal.pcbi.1003709. eCollection 2014 Jul.


Comparisons of non-Gaussian statistical models in DNA methylation analysis.

Ma Z, Teschendorff AE, Yu H, Taghia J, Guo J.

Int J Mol Sci. 2014 Jun 16;15(6):10835-54. doi: 10.3390/ijms150610835.


A systems-level integrative framework for genome-wide DNA methylation and gene expression data identifies differential gene expression modules under epigenetic control.

Jiao Y, Widschwendter M, Teschendorff AE.

Bioinformatics. 2014 Aug 15;30(16):2360-6. doi: 10.1093/bioinformatics/btu316. Epub 2014 May 2.

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