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Proposals for enhanced health risk assessment and stratification in an integrated care scenario.

Dueñas-Espín I, Vela E, Pauws S, Bescos C, Cano I, Cleries M, Contel JC, de Manuel Keenoy E, Garcia-Aymerich J, Gomez-Cabrero D, Kaye R, Lahr MM, Lluch-Ariet M, Moharra M, Monterde D, Mora J, Nalin M, Pavlickova A, Piera J, Ponce S, Santaeugenia S, Schonenberg H, Störk S, Tegner J, Velickovski F, Westerteicher C, Roca J.

BMJ Open. 2016 Apr 15;6(4):e010301. doi: 10.1136/bmjopen-2015-010301.


Human macrophages induce CD4+Foxp3+ regulatory T cells via binding and re-release of TGF-β.

Schmidt A, Zhang XM, Joshi RN, Iqbal S, Wahlund C, Gabrielsson S, Harris RA, Tegnér J.

Immunol Cell Biol. 2016 Apr 14. doi: 10.1038/icb.2016.34. [Epub ahead of print]


Comparative Analysis of Protocols to Induce Human CD4+Foxp3+ Regulatory T Cells by Combinations of IL-2, TGF-beta, Retinoic Acid, Rapamycin and Butyrate.

Schmidt A, Eriksson M, Shang MM, Weyd H, Tegnér J.

PLoS One. 2016 Feb 17;11(2):e0148474. doi: 10.1371/journal.pone.0148474. eCollection 2016.


Evaluating network inference methods in terms of their ability to preserve the topology and complexity of genetic networks.

Kiani NA, Zenil H, Olczak J, Tegnér J.

Semin Cell Dev Biol. 2016 Mar;51:44-52. doi: 10.1016/j.semcdb.2016.01.012. Epub 2016 Feb 3. Review.


Methods of information theory and algorithmic complexity for network biology.

Zenil H, Kiani NA, Tegnér J.

Semin Cell Dev Biol. 2016 Mar;51:32-43. doi: 10.1016/j.semcdb.2016.01.011. Epub 2016 Jan 21. Review.


Bioinformatics Mining and Modeling Methods for the Identification of Disease Mechanisms in Neurodegenerative Disorders.

Hofmann-Apitius M, Ball G, Gebel S, Bagewadi S, de Bono B, Schneider R, Page M, Kodamullil AT, Younesi E, Ebeling C, Tegnér J, Canard L.

Int J Mol Sci. 2015 Dec 7;16(12):29179-206. doi: 10.3390/ijms161226148. Review.


From Systems Understanding to Personalized Medicine: Lessons and Recommendations Based on a Multidisciplinary and Translational Analysis of COPD.

Roca J, Cano I, Gomez-Cabrero D, Tegnér J.

Methods Mol Biol. 2016;1386:283-303. doi: 10.1007/978-1-4939-3283-2_13.


The folate-coupled enzyme MTHFD2 is a nuclear protein and promotes cell proliferation.

Gustafsson Sheppard N, Jarl L, Mahadessian D, Strittmatter L, Schmidt A, Madhusudan N, Tegnér J, Lundberg EK, Asplund A, Jain M, Nilsson R.

Sci Rep. 2015 Oct 13;5:15029. doi: 10.1038/srep15029.


IL-1β promotes Th17 differentiation by inducing alternative splicing of FOXP3.

Mailer RK, Joly AL, Liu S, Elias S, Tegner J, Andersson J.

Sci Rep. 2015 Oct 6;5:14674. doi: 10.1038/srep14674.


Normalization of circulating microRNA expression data obtained by quantitative real-time RT-PCR.

Marabita F, de Candia P, Torri A, Tegnér J, Abrignani S, Rossi RL.

Brief Bioinform. 2016 Mar;17(2):204-12. doi: 10.1093/bib/bbv056. Epub 2015 Aug 3.


In Search of 'Omics'-Based Biomarkers to Predict Risk of Frailty and Its Consequences in Older Individuals: The FRAILOMIC Initiative.

Erusalimsky JD, Grillari J, Grune T, Jansen-Duerr P, Lippi G, Sinclair AJ, Tegnér J, Viña J, Durrance-Bagale A, Miñambres R, Viegas M, Rodríguez-Mañas L; FRAILOMIC Consortium.

Gerontology. 2016;62(2):182-90. doi: 10.1159/000435853. Epub 2015 Jul 23.


Monozygotic twins discordant for common variable immunodeficiency reveal impaired DNA demethylation during naïve-to-memory B-cell transition.

Rodríguez-Cortez VC, Del Pino-Molina L, Rodríguez-Ubreva J, Ciudad L, Gómez-Cabrero D, Company C, Urquiza JM, Tegnér J, Rodríguez-Gallego C, López-Granados E, Ballestar E.

Nat Commun. 2015 Jun 17;6:7335. doi: 10.1038/ncomms8335.


Laboratory biomarkers and frailty: presentation of the FRAILOMIC initiative.

Lippi G, Jansen-Duerr P, Viña J, Durrance-Bagale A, Abugessaisa I, Gomez-Cabrero D, Tegnér J, Grillari J, Erusalimsky J, Sinclair A, Rodriguez-Manãs L; FRAILOMIC consortium.

Clin Chem Lab Med. 2015 Sep 1;53(10):e253-5. doi: 10.1515/cclm-2015-0147. No abstract available.


VEGF-B promotes cancer metastasis through a VEGF-A-independent mechanism and serves as a marker of poor prognosis for cancer patients.

Yang X, Zhang Y, Hosaka K, Andersson P, Wang J, Tholander F, Cao Z, Morikawa H, Tegnér J, Yang Y, Iwamoto H, Lim S, Cao Y.

Proc Natl Acad Sci U S A. 2015 Jun 2;112(22):E2900-9. doi: 10.1073/pnas.1503500112. Epub 2015 May 19.


An integrative analysis reveals coordinated reprogramming of the epigenome and the transcriptome in human skeletal muscle after training.

Lindholm ME, Marabita F, Gomez-Cabrero D, Rundqvist H, Ekström TJ, Tegnér J, Sundberg CJ.

Epigenetics. 2014 Dec;9(12):1557-69. doi: 10.4161/15592294.2014.982445.


Chronic Obstructive Pulmonary Disease heterogeneity: challenges for health risk assessment, stratification and management.

Roca J, Vargas C, Cano I, Selivanov V, Barreiro E, Maier D, Falciani F, Wagner P, Cascante M, Garcia-Aymerich J, Kalko S, De Mas I, Tegnér J, Escarrabill J, Agustí A, Gomez-Cabrero D; Synergy-COPD consortium.

J Transl Med. 2014 Nov 28;12 Suppl 2:S3. doi: 10.1186/1479-5876-12-S2-S3. Epub 2014 Nov 28. Review.


Synergy-COPD: a systems approach for understanding and managing chronic diseases.

Gomez-Cabrero D, Lluch-Ariet M, Tegnér J, Cascante M, Miralles F, Roca J; Synergy-COPD consortium.

J Transl Med. 2014 Nov 28;12 Suppl 2:S2. doi: 10.1186/1479-5876-12-S2-S2. Epub 2014 Nov 28.


Predictive medicine: outcomes, challenges and opportunities in the Synergy-COPD project.

Miralles F, Gomez-Cabrero D, Lluch-Ariet M, Tegnér J, Cascante M, Roca J; Synergy-COPD consortium.

J Transl Med. 2014 Nov 28;12 Suppl 2:S12. doi: 10.1186/1479-5876-12-S2-S12. Epub 2014 Nov 28. Review.


Biomedical research in a Digital Health Framework.

Cano I, Lluch-Ariet M, Gomez-Cabrero D, Maier D, Kalko S, Cascante M, Tegnér J, Miralles F, Herrera D, Roca J; Synergy-COPD consortium.

J Transl Med. 2014 Nov 28;12 Suppl 2:S10. doi: 10.1186/1479-5876-12-S2-S10. Epub 2014 Nov 28.


Systems Medicine: from molecular features and models to the clinic in COPD.

Gomez-Cabrero D, Menche J, Cano I, Abugessaisa I, Huertas-Migueláñez M, Tenyi A, Marin de Mas I, Kiani NA, Marabita F, Falciani F, Burrowes K, Maier D, Wagner P, Selivanov V, Cascante M, Roca J, Barabási AL, Tegnér J.

J Transl Med. 2014 Nov 28;12 Suppl 2:S4. doi: 10.1186/1479-5876-12-S2-S4. Epub 2014 Nov 28.

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