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2016 | 1 |
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Targeting autophagy potentiates tyrosine kinase inhibitor-induced cell death in Philadelphia chromosome-positive cells, including primary CML stem cells.
J Clin Invest. 2009 May;119(5):1109-23. doi: 10.1172/JCI35660. Epub 2009 Apr 13.
J Clin Invest. 2009.
PMID: 19363292
Free PMC article.
We further demonstrated that suppression of autophagy using either pharmacological inhibitors or RNA interference of essential autophagy genes enhanced cell death induced by IM in cell lines and primary CML cells …
We further demonstrated that suppression of autophagy using either pharmacological inhibitors or RNA interference of essential …
ATG7 regulates energy metabolism, differentiation and survival of Philadelphia-chromosome-positive cells.
Karvela M, Baquero P, Kuntz EM, Mukhopadhyay A, Mitchell R, Allan EK, Chan E, Kranc KR, Calabretta B, Salomoni P, Gottlieb E, Holyoake TL, Helgason GV.
Karvela M, et al.
Autophagy. 2016 Jun 2;12(6):936-48. doi: 10.1080/15548627.2016.1162359. Epub 2016 May 11.
Autophagy. 2016.
PMID: 27168493
Free PMC article.
A major drawback of tyrosine kinase inhibitor (TKI) treatment in chronic myeloid leukemia (CML) is that primitive CML cells are able to survive TKI-mediated BCR-ABL inhibition, leading to disease persistence in patients. Investigation of …
A major drawback of tyrosine kinase inhibitor (TKI) treatment in chronic myeloid leukemia (CML) is that primitiv …
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