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Results: 1 to 20 of 307

1.

Peripheral surgical wounding and age-dependent neuroinflammation in mice.

Xu Z, Dong Y, Wang H, Culley DJ, Marcantonio ER, Crosby G, Tanzi RE, Zhang Y, Xie Z.

PLoS One. 2014 May 5;9(5):e96752. doi: 10.1371/journal.pone.0096752. eCollection 2014.

PMID:
24796537
[PubMed - in process]
Free PMC Article
2.

Age-dependent, non-cell-autonomous deposition of amyloid from synthesis of β-amyloid by cells other than excitatory neurons.

Veeraraghavalu K, Zhang C, Zhang X, Tanzi RE, Sisodia SS.

J Neurosci. 2014 Mar 5;34(10):3668-73. doi: 10.1523/JNEUROSCI.5079-13.2014.

PMID:
24599465
[PubMed - indexed for MEDLINE]
3.

Age-dependent postoperative cognitive impairment and Alzheimer-related neuropathology in mice.

Xu Z, Dong Y, Wang H, Culley DJ, Marcantonio ER, Crosby G, Tanzi RE, Zhang Y, Xie Z.

Sci Rep. 2014 Jan 20;4:3766. doi: 10.1038/srep03766.

PMID:
24441878
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Soluble γ-secretase modulators selectively inhibit the production of the 42-amino acid amyloid β peptide variant and augment the production of multiple carboxy-truncated amyloid β species.

Wagner SL, Zhang C, Cheng S, Nguyen P, Zhang X, Rynearson KD, Wang R, Li Y, Sisodia SS, Mobley WC, Tanzi RE.

Biochemistry. 2014 Feb 4;53(4):702-13. doi: 10.1021/bi401537v. Epub 2014 Jan 22.

PMID:
24401146
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

TREM2 and neurodegenerative disease.

Bertram L, Parrado AR, Tanzi RE.

N Engl J Med. 2013 Oct 17;369(16):1565. doi: 10.1056/NEJMc1306509#SA2. No abstract available.

PMID:
24131185
[PubMed - indexed for MEDLINE]
6.

ADAM10 missense mutations potentiate β-amyloid accumulation by impairing prodomain chaperone function.

Suh J, Choi SH, Romano DM, Gannon MA, Lesinski AN, Kim DY, Tanzi RE.

Neuron. 2013 Oct 16;80(2):385-401. doi: 10.1016/j.neuron.2013.08.035. Epub 2013 Sep 19.

PMID:
24055016
[PubMed - indexed for MEDLINE]
7.

Elucidation of the BACE1 regulating factor GGA3 in Alzheimer's disease.

Natunen T, Parrado AR, Helisalmi S, Pursiheimo JP, Sarajärvi T, Mäkinen P, Kurkinen KM, Mullin K, Alafuzoff I, Haapasalo A, Bertram L, Soininen H, Tanzi RE, Hiltunen M.

J Alzheimers Dis. 2013;37(1):217-32. doi: 10.3233/JAD-130104.

PMID:
23970038
[PubMed - indexed for MEDLINE]
8.

Rare autosomal copy number variations in early-onset familial Alzheimer's disease.

Hooli BV, Kovacs-Vajna ZM, Mullin K, Blumenthal MA, Mattheisen M, Zhang C, Lange C, Mohapatra G, Bertram L, Tanzi RE.

Mol Psychiatry. 2014 Jun;19(6):676-81. doi: 10.1038/mp.2013.77. Epub 2013 Jun 11.

PMID:
23752245
[PubMed - in process]
9.

Cerebrospinal fluid aβ to tau ratio and postoperative cognitive change.

Xie Z, McAuliffe S, Swain CA, Ward SA, Crosby CA, Zheng H, Sherman J, Dong Y, Zhang Y, Sunder N, Burke D, Washicosky KJ, Tanzi RE, Marcantonio ER.

Ann Surg. 2013 Aug;258(2):364-9. doi: 10.1097/SLA.0b013e318298b077.

PMID:
23732272
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Comment on "ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models".

Veeraraghavalu K, Zhang C, Miller S, Hefendehl JK, Rajapaksha TW, Ulrich J, Jucker M, Holtzman DM, Tanzi RE, Vassar R, Sisodia SS.

Science. 2013 May 24;340(6135):924-f. doi: 10.1126/science.1235505.

PMID:
23704555
[PubMed - indexed for MEDLINE]
Free Article
11.

Silencing of the Drosophila ortholog of SOX5 in heart leads to cardiac dysfunction as detected by optical coherence tomography.

Li A, Ahsen OO, Liu JJ, Du C, McKee ML, Yang Y, Wasco W, Newton-Cheh CH, O'Donnell CJ, Fujimoto JG, Zhou C, Tanzi RE.

Hum Mol Genet. 2013 Sep 15;22(18):3798-806. doi: 10.1093/hmg/ddt230. Epub 2013 May 21.

PMID:
23696452
[PubMed - indexed for MEDLINE]
12.

Ubiquilin-1 modulates γ-secretase-mediated ε-site cleavage in neuronal cells.

Viswanathan J, Haapasalo A, Kurkinen KM, Natunen T, Mäkinen P, Bertram L, Soininen H, Tanzi RE, Hiltunen M.

Biochemistry. 2013 Jun 4;52(22):3899-912. doi: 10.1021/bi400138p. Epub 2013 May 21.

PMID:
23663107
[PubMed - indexed for MEDLINE]
13.

Alzheimer's disease risk gene CD33 inhibits microglial uptake of amyloid beta.

Griciuc A, Serrano-Pozo A, Parrado AR, Lesinski AN, Asselin CN, Mullin K, Hooli B, Choi SH, Hyman BT, Tanzi RE.

Neuron. 2013 May 22;78(4):631-43. doi: 10.1016/j.neuron.2013.04.014. Epub 2013 Apr 25.

PMID:
23623698
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Targeting ubiquilin-1 in Alzheimer's disease.

Takalo M, Haapasalo A, Natunen T, Viswanathan J, Kurkinen KM, Tanzi RE, Soininen H, Hiltunen M.

Expert Opin Ther Targets. 2013 Jul;17(7):795-810. doi: 10.1517/14728222.2013.791284. Epub 2013 Apr 21. Review.

PMID:
23600477
[PubMed - indexed for MEDLINE]
15.

RNAi-mediated knock-down of Dab and Numb attenuate Aβ levels via γ-secretase mediated APP processing.

Xie Z, Dong Y, Maeda U, Xia W, Tanzi RE.

Transl Neurodegener. 2012 Mar 22;1(1):8. doi: 10.1186/2047-9158-1-8.

PMID:
23211096
[PubMed]
Free PMC Article
16.

The genetics of Alzheimer disease.

Tanzi RE.

Cold Spring Harb Perspect Med. 2012 Oct 1;2(10). pii: a006296. doi: 10.1101/cshperspect.a006296. Review.

PMID:
23028126
[PubMed - indexed for MEDLINE]
17.

Natural Modulators of Amyloid-Beta Precursor Protein Processing.

Zhang C, Tanzi RE.

Curr Alzheimer Res. 2012 Sep 13. [Epub ahead of print]

PMID:
22998566
[PubMed - as supplied by publisher]
Free PMC Article
18.

A brief history of Alzheimer's disease gene discovery.

Tanzi RE.

J Alzheimers Dis. 2013;33 Suppl 1:S5-13. Review.

PMID:
22986781
[PubMed - indexed for MEDLINE]
19.

SUMO1 modulates Aβ generation via BACE1 accumulation.

Yun SM, Cho SJ, Song JC, Song SY, Jo SA, Jo C, Yoon K, Tanzi RE, Choi EJ, Koh YH.

Neurobiol Aging. 2013 Mar;34(3):650-62. doi: 10.1016/j.neurobiolaging.2012.08.005. Epub 2012 Sep 11.

PMID:
22975420
[PubMed - indexed for MEDLINE]
20.

Potential use of γ-secretase modulators in the treatment of Alzheimer disease.

Wagner SL, Tanzi RE, Mobley WC, Galasko D.

Arch Neurol. 2012 Oct;69(10):1255-8. Review.

PMID:
22801784
[PubMed - indexed for MEDLINE]
Free PMC Article

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