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A quantitative analysis of therapeutic cancer vaccines in phase 2 or phase 3 trial.

Tan AC, Goubier A, Kohrt HE.

J Immunother Cancer. 2015 Nov 17;3:48. eCollection 2015. Review.


Aging-associated inflammation promotes selection for adaptive oncogenic events in B cell progenitors.

Henry CJ, Casás-Selves M, Kim J, Zaberezhnyy V, Aghili L, Daniel AE, Jimenez L, Azam T, McNamee EN, Clambey ET, Klawitter J, Serkova NJ, Tan AC, Dinarello CA, DeGregori J.

J Clin Invest. 2015 Nov 9. pii: 83024. doi: 10.1172/JCI83024. [Epub ahead of print]


Author Response: Use of Clopidogrel and Poor Visual Outcome.

Jung JJ, Chae B, Tan AC, Patel SN, Freund KB.

Invest Ophthalmol Vis Sci. 2015 Nov 1;56(12):7052. doi: 10.1167/iovs.15-18289. No abstract available.


Inactivated Influenza Vaccine That Provides Rapid, Innate-Immune-System-Mediated Protection and Subsequent Long-Term Adaptive Immunity.

Chua BY, Wong CY, Mifsud EJ, Edenborough KM, Sekiya T, Tan AC, Mercuri F, Rockman S, Chen W, Turner SJ, Doherty PC, Kelso A, Brown LE, Jackson DC.

MBio. 2015 Oct 27;6(6). pii: e01024-15. doi: 10.1128/mBio.01024-15.


Antitumor activity of a potent MEK inhibitor, TAK-733, against colorectal cancer cell lines and patient derived xenografts.

Lieu CH, Klauck PJ, Henthorn PK, Tentler JJ, Tan AC, Spreafico A, Selby HM, Britt BC, Bagby SM, Arcaroli JJ, Messersmith WA, Pitts TM, Eckhardt SG.

Oncotarget. 2015 Oct 27;6(33):34561-72. doi: 10.18632/oncotarget.5949.


Kinome RNAi Screens Reveal Synergistic Targeting of MTOR and FGFR1 Pathways for Treatment of Lung Cancer and HNSCC.

Singleton KR, Hinz TK, Kleczko EK, Marek LA, Kwak J, Harp T, Kim J, Tan AC, Heasley LE.

Cancer Res. 2015 Oct 15;75(20):4398-406. doi: 10.1158/0008-5472.CAN-15-0509. Epub 2015 Sep 10.


Mapping the pulmonary environment of animals protected from virulent H1N1 influenza infection using the TLR-2 agonist Pam2Cys.

Mifsud EJ, Tan AC, Reading PC, Jackson DC.

Immunol Cell Biol. 2015 Aug 14. doi: 10.1038/icb.2015.81. [Epub ahead of print]


Identifying kinase dependency in cancer cells by integrating high-throughput drug screening and kinase inhibition data.

Ryall KA, Shin J, Yoo M, Hinz TK, Kim J, Kang J, Heasley LE, Tan AC.

Bioinformatics. 2015 Dec 1;31(23):3799-806. doi: 10.1093/bioinformatics/btv427. Epub 2015 Jul 23.


A NOTCH1 gene copy number gain is a prognostic indicator of worse survival and a predictive biomarker to a Notch1 targeting antibody in colorectal cancer.

Arcaroli JJ, Tai WM, McWilliams R, Bagby S, Blatchford PJ, Varella-Garcia M, Purkey A, Quackenbush KS, Song EK, Pitts TM, Gao D, Lieu C, McManus M, Tan AC, Zheng X, Zhang Q, Ozeck M, Olson P, Jiang ZQ, Kopetz S, Jimeno A, Keysar S, Eckhardt G, Messersmith WA.

Int J Cancer. 2016 Jan 1;138(1):195-205. doi: 10.1002/ijc.29676. Epub 2015 Jul 22.


iCOSSY: An Online Tool for Context-Specific Subnetwork Discovery from Gene Expression Data.

Saha A, Jeon M, Tan AC, Kang J.

PLoS One. 2015 Jul 6;10(7):e0131656. doi: 10.1371/journal.pone.0131656. eCollection 2015.


Combined inhibition of MEK and Aurora A kinase in KRAS/PIK3CA double-mutant colorectal cancer models.

Davis SL, Robertson KM, Pitts TM, Tentler JJ, Bradshaw-Pierce EL, Klauck PJ, Bagby SM, Hyatt SL, Selby HM, Spreafico A, Ecsedy JA, Arcaroli JJ, Messersmith WA, Tan AC, Eckhardt SG.

Front Pharmacol. 2015 Jun 16;6:120. doi: 10.3389/fphar.2015.00120. eCollection 2015.


Reducing the impact of influenza-associated secondary pneumococcal infections.

Mifsud EJ, Tan AC, Short KR, Brown LE, Chua BY, Jackson DC.

Immunol Cell Biol. 2015 Jul 21. doi: 10.1038/icb.2015.71. [Epub ahead of print]


Mammary epithelial cell phagocytosis downstream of TGF-β3 is characterized by adherens junction reorganization.

Fornetti J, Flanders KC, Henson PM, Tan AC, Borges VF, Schedin P.

Cell Death Differ. 2015 Jun 26. doi: 10.1038/cdd.2015.82. [Epub ahead of print]


Generation of Adaptive Immune Responses Following Influenza Virus Challenge is Not Compromised by Pre-Treatment with the TLR-2 Agonist Pam2Cys.

Mifsud EJ, Tan AC, Brown LE, Chua BY, Jackson DC.

Front Immunol. 2015 Jun 5;6:290. doi: 10.3389/fimmu.2015.00290. eCollection 2015.


Comparative Haploid Genetic Screens Reveal Divergent Pathways in the Biogenesis and Trafficking of Glycophosphatidylinositol-Anchored Proteins.

Davis EM, Kim J, Menasche BL, Sheppard J, Liu X, Tan AC, Shen J.

Cell Rep. 2015 Jun 23;11(11):1727-36. doi: 10.1016/j.celrep.2015.05.026. Epub 2015 Jun 11.


An ethnopharmacological approach to the preliminary screening of native Australian herbal medicines for anticancer activity.

Tan AC, Konczak I, Li G, Roufogalis BD, Sekhon B, Sze DM.

J Complement Integr Med. 2015 Sep;12(3):245-9. doi: 10.1515/jcim-2014-0017.


A lipidated form of the extracellular domain of influenza M2 protein as a self-adjuvanting vaccine candidate.

Zeng W, Tan AC, Horrocks K, Jackson DC.

Vaccine. 2015 Jul 9;33(30):3526-32. doi: 10.1016/j.vaccine.2015.05.053. Epub 2015 Jun 3.


FGFR1 Expression Levels Predict BGJ398 Sensitivity of FGFR1-Dependent Head and Neck Squamous Cell Cancers.

Göke F, Franzen A, Hinz TK, Marek LA, Yoon P, Sharma R, Bode M, von Maessenhausen A, Lankat-Buttgereit B, Göke A, Golletz C, Kirsten R, Boehm D, Vogel W, Kleczko EK, Eagles JR, Hirsch FR, Van Bremen T, Bootz F, Schroeck A, Kim J, Tan AC, Jimeno A, Heasley LE, Perner S.

Clin Cancer Res. 2015 Oct 1;21(19):4356-64. doi: 10.1158/1078-0432.CCR-14-3357. Epub 2015 May 26.


DSigDB: drug signatures database for gene set analysis.

Yoo M, Shin J, Kim J, Ryall KA, Lee K, Lee S, Jeon M, Kang J, Tan AC.

Bioinformatics. 2015 Sep 15;31(18):3069-71. doi: 10.1093/bioinformatics/btv313. Epub 2015 May 19.


An Inducible TGF-β2-TGFβR Pathway Modulates the Sensitivity of HNSCC Cells to Tyrosine Kinase Inhibitors Targeting Dominant Receptor Tyrosine Kinases.

Kleczko EK, Kim J, Keysar SB, Heasley LR, Eagles JR, Simon M, Marshall ME, Singleton KR, Jimeno A, Tan AC, Heasley LE.

PLoS One. 2015 May 6;10(5):e0123600. doi: 10.1371/journal.pone.0123600. eCollection 2015.

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