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Page 1
The thyromimetic T-0681 protects from atherosclerosis.
Tancevski I, Wehinger A, Demetz E, Hoefer J, Eller P, Huber E, Stanzl U, Duwensee K, Auer K, Schgoer W, Kuhn V, Fievet C, Stellaard F, Rudling M, Foeger B, Patsch JR, Ritsch A. Tancevski I, et al. J Lipid Res. 2009 May;50(5):938-44. doi: 10.1194/jlr.M800553-JLR200. Epub 2008 Dec 22. J Lipid Res. 2009. PMID: 19106072 Free PMC article.
This report describes studies in hyperlipidemic New Zealand White (NZW) rabbits investigating the impact of the liver-selective thyromimetic T-0681 on lipoprotein metabolism and the development of atherosclerosis. Prolonged treatment with T-0681 increased the hepati …
This report describes studies in hyperlipidemic New Zealand White (NZW) rabbits investigating the impact of the liver-selective thyromime …
Emerging therapeutic agents to lower lipoprotein (a) levels.
Kolski B, Tsimikas S. Kolski B, et al. Curr Opin Lipidol. 2012 Dec;23(6):560-8. doi: 10.1097/MOL.0b013e3283598d81. Curr Opin Lipidol. 2012. PMID: 23041907 Review.
However, recent data has demonstrated that Lp(a) can be significantly lowered, along with reductions in other apolipoprotein B-100 (apoB) containing lipoproteins, with antisense oligonucleotides to apoB, monoclonal antibodies to proprotein convertase subtilisin/kexin type …
However, recent data has demonstrated that Lp(a) can be significantly lowered, along with reductions in other apolipoprotein B-100 (apoB) co …
Effects of L-triiodothyronine and the thyromimetic L-94901 on serum lipoprotein levels and hepatic low-density lipoprotein receptor, 3-hydroxy-3-methylglutaryl coenzyme A reductase, and apo A-I gene expression.
Ness GC, Lopez D, Chambers CM, Newsome WP, Cornelius P, Long CA, Harwood HJ Jr. Ness GC, et al. Biochem Pharmacol. 1998 Jul 1;56(1):121-9. doi: 10.1016/s0006-2952(98)00119-1. Biochem Pharmacol. 1998. PMID: 9698096
The mechanisms by which thyroid hormone (triiodothyronine (T3)) and a thyromimetic, 2-amino-3-(3,5-dibromo-4-[4-hydroxy-3-(6-oxo-1,6-dihydro-pyridazin -3-ylmethyl)-phenoxyl]-phenyl)propionic acid (L-94901), lower plasma low density lipoprotein (LDL) cholesterol and …
The mechanisms by which thyroid hormone (triiodothyronine (T3)) and a thyromimetic, 2-amino-3-(3,5-dibromo-4-[4-hydroxy-3-(6-oxo-1,6- …
Beneficial effects of a novel thyromimetic on lipoprotein metabolism.
Taylor AH, Stephan ZF, Steele RE, Wong NC. Taylor AH, et al. Mol Pharmacol. 1997 Sep;52(3):542-7. doi: 10.1124/mol.52.3.542. Mol Pharmacol. 1997. PMID: 9281617
Although L-triiodothyronine (L-T3) lowers cholesterol, this hormone is not used to treat hypercholesterolemia because of its cardiotoxic effects. Thyromimetics, such as the novel compound CGS 23425, that mimic the beneficial but lack the detrimental effects of T3, may be u …
Although L-triiodothyronine (L-T3) lowers cholesterol, this hormone is not used to treat hypercholesterolemia because of its cardiotoxic eff …
Thyromimetic effect of peroxisome proliferators.
Hertz R, Kalderon B, Bar-Tana J. Hertz R, et al. Biochimie. 1993;75(3-4):257-61. doi: 10.1016/0300-9084(93)90085-7. Biochimie. 1993. PMID: 8507688 Review.
The thyromimetic effect of PP was found not to be mediated by the TH nuclear receptor. ...The overall thyromimetic effect of PP appears to involve transcriptional activation of TH-dependent genes, yet being mediated by a novel transduction pathway....
The thyromimetic effect of PP was found not to be mediated by the TH nuclear receptor. ...The overall thyromimetic effect of P …
Novel therapeutic agents for lowering low density lipoprotein cholesterol.
Joy TR. Joy TR. Pharmacol Ther. 2012 Jul;135(1):31-43. doi: 10.1016/j.pharmthera.2012.03.005. Epub 2012 Mar 23. Pharmacol Ther. 2012. PMID: 22465160 Review.
Elevated low density lipoprotein cholesterol (LDL-C) levels have been associated with an increased risk for cardiovascular disease (CVD). ...This review will highlight some of these therapeutic agents including anti-sense oligonucleotides focused on apolipoprotein B, propr …
Elevated low density lipoprotein cholesterol (LDL-C) levels have been associated with an increased risk for cardiovascular disease (C …
Discovery Approaches for Novel Dyslipidemia Drugs.
Maqbool F, Safavi M, Bahadar H, Rahimifard M, Niaz K, Abdollahi M. Maqbool F, et al. Curr Drug Discov Technol. 2015;12(2):90-116. doi: 10.2174/1570163812666150702121809. Curr Drug Discov Technol. 2015. PMID: 26135857 Review.
During the past few years, nucleic acid-based therapies targeting lipid and lipoprotein metabolism, such as microsomal TG transfer protein (MTP) may be a promising therapeutic approach to treat vascular diseases. ...Virtual screening, an important tool in screening databas …
During the past few years, nucleic acid-based therapies targeting lipid and lipoprotein metabolism, such as microsomal TG transfer pr …
Thyromimetics: a journey from bench to bed-side.
Tancevski I, Rudling M, Eller P. Tancevski I, et al. Pharmacol Ther. 2011 Jul;131(1):33-9. doi: 10.1016/j.pharmthera.2011.04.003. Epub 2011 Apr 12. Pharmacol Ther. 2011. PMID: 21504761 Review.
Selective thyromimetics are synthetic analogs of thyroid hormones with tissue-specific thyroid hormone actions. ...Thyromimetics consistently and efficiently lowered low-density lipoprotein cholesterol and lipoprotein (a) plasma levels without positive …
Selective thyromimetics are synthetic analogs of thyroid hormones with tissue-specific thyroid hormone actions. ...Thyromimetics …
Thyroid Hormone Mimetics: the Past, Current Status and Future Challenges.
Elbers LP, Kastelein JJ, Sjouke B. Elbers LP, et al. Curr Atheroscler Rep. 2016 Mar;18(3):14. doi: 10.1007/s11883-016-0564-7. Curr Atheroscler Rep. 2016. PMID: 26886134 Free PMC article. Review.
The association between thyroid hormone status and plasma levels of low-density lipoprotein cholesterol has raised the awareness for the development of thyroid hormone mimetics as lipid-lowering agents. ...In the past decades, several thyroid hormone mimetics have been inv …
The association between thyroid hormone status and plasma levels of low-density lipoprotein cholesterol has raised the awareness for …
The resurgence of thyromimetics as lipid-modifying agents.
Tancevski I, Eller P, Patsch JR, Ritsch A. Tancevski I, et al. Curr Opin Investig Drugs. 2009 Sep;10(9):912-8. Curr Opin Investig Drugs. 2009. PMID: 19705333 Free PMC article. Review.
In preclinical studies, selective thyromimetics significantly reduced plasma cholesterol levels and provided protection from atherosclerosis by upregulating the hepatic LDL receptor and promoting reverse cholesterol transport. Importantly, data from ongoing clinical trials …
In preclinical studies, selective thyromimetics significantly reduced plasma cholesterol levels and provided protection from atherosc …
35 results