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AIDS Res Hum Retroviruses. 2013 Jan;29(1):94-8. doi: 10.1089/AID.2012.0071. Epub 2012 Sep 4.

Short communication: T cell activation in HIV-1/herpes simplex virus-2-coinfected Kenyan women receiving valacyclovir.

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  • 1Department of Medicine, University of Washington, Seattle, WA 98104, USA. aroxby@u.washington.edu

Abstract

Herpes simplex virus-2 (HSV-2) suppression with acyclovir or valacyclovir reduces HIV-1 viral RNA levels; one hypothesis is that HSV-2 suppression reduces immune activation. We measured T cell immune activation markers among women participating in a randomized placebo-controlled trial of valacyclovir to reduce HIV-1 RNA levels among pregnant women. Although valacyclovir was associated with lower HIV-1 RNA levels, the distribution of both CD4(+) and CD8(+) CD38(+)HLA-DR(+) T cells was not different among women taking valacyclovir when compared to women taking placebo. Further study is needed to understand the mechanism of HIV-1 RNA reduction following herpes suppression among those coinfected with HIV-1 and HSV-2.

PMID:
22852760
[PubMed - indexed for MEDLINE]
PMCID:
PMC3537320
Free PMC Article

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