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Recombinant vaccinia virus GLV-1h68 is a promising oncolytic vector in the treatment of cholangiocarcinoma.

Pugalenthi A, Mojica K, Ady JW, Johnsen C, Love D, Chen NG, Aguilar RJ, Szalay AA, Fong Y.

Cancer Gene Ther. 2015 Dec;22(12):591-6. doi: 10.1038/cgt.2015.60. Epub 2015 Nov 20.


Drug-Encoded Biomarkers for Monitoring Biological Therapies.

Tsoneva D, Stritzker J, Bedenk K, Zhang Q, Frentzen A, Cappello J, Fischer U, Szalay AA.

PLoS One. 2015 Sep 8;10(9):e0137573. doi: 10.1371/journal.pone.0137573. eCollection 2015.


Preclinical Testing Oncolytic Vaccinia Virus Strain GLV-5b451 Expressing an Anti-VEGF Single-Chain Antibody for Canine Cancer Therapy.

Adelfinger M, Bessler S, Frentzen A, Cecil A, Langbein-Laugwitz J, Gentschev I, Szalay AA.

Viruses. 2015 Jul 20;7(7):4075-92. doi: 10.3390/v7072811.


Doxycycline Inducible Melanogenic Vaccinia Virus as Theranostic Anti-Cancer Agent.

Kirscher L, Deán-Ben XL, Scadeng M, Zaremba A, Zhang Q, Kober C, Fehm TF, Razansky D, Ntziachristos V, Stritzker J, Szalay AA.

Theranostics. 2015 Jun 15;5(10):1045-57. doi: 10.7150/thno.12533. eCollection 2015.


Microglia and astrocytes attenuate the replication of the oncolytic vaccinia virus LIVP 1.1.1 in murine GL261 gliomas by acting as vaccinia virus traps.

Kober C, Rohn S, Weibel S, Geissinger U, Chen NG, Szalay AA.

J Transl Med. 2015 Jul 7;13:216. doi: 10.1186/s12967-015-0586-x.


Oncolytic gene therapy with recombinant vaccinia strain GLV-2b372 efficiently kills hepatocellular carcinoma.

Ady JW, Johnsen C, Mojica K, Heffner J, Love D, Pugalenthi A, Belin LJ, Chen NG, Yu YA, Szalay AA, Fong Y.

Surgery. 2015 Aug;158(2):331-8. doi: 10.1016/j.surg.2015.03.044. Epub 2015 Jun 3.


Gene therapy using therapeutic and diagnostic recombinant oncolytic vaccinia virus GLV-1h153 for management of colorectal peritoneal carcinomatosis.

Eveno C, Mojica K, Ady JW, Thorek DL, Longo V, Belin LJ, Gholami S, Johnsen C, Zanzonico P, Chen N, Yu T, Szalay AA, Fong Y.

Surgery. 2015 Feb;157(2):331-7. doi: 10.1016/j.surg.2014.09.008.


Antigen profiling analysis of vaccinia virus injected canine tumors: oncolytic virus efficiency predicted by boolean models.

Cecil A, Gentschev I, Adelfinger M, Nolte I, Dandekar T, Szalay AA.

Bioengineered. 2014 Sep-Oct;5(5):319-25. doi: 10.4161/bioe.32227.


Silk-elastin-like protein polymer matrix for intraoperative delivery of an oncolytic vaccinia virus.

Price DL, Li P, Chen CH, Wong D, Yu Z, Chen NG, Yu YA, Szalay AA, Cappello J, Fong Y, Wong RJ.

Head Neck. 2016 Feb;38(2):237-46. doi: 10.1002/hed.23877. Epub 2015 Jun 16.


Evaluation of a new recombinant oncolytic vaccinia virus strain GLV-5b451 for feline mammary carcinoma therapy.

Adelfinger M, Gentschev I, Grimm de Guibert J, Weibel S, Langbein-Laugwitz J, Härtl B, Murua Escobar H, Nolte I, Chen NG, Aguilar RJ, Yu YA, Zhang Q, Frentzen A, Szalay AA.

PLoS One. 2014 Aug 5;9(8):e104337. doi: 10.1371/journal.pone.0104337. eCollection 2014.


Inducible gene expression in tumors colonized by modified oncolytic vaccinia virus strains.

Stritzker J, Huppertz S, Zhang Q, Geissinger U, Härtl B, Gentschev I, Szalay AA.

J Virol. 2014 Oct;88(19):11556-67. doi: 10.1128/JVI.00681-14. Epub 2014 Jul 23.


Isolated limb perfusion with melphalan, tumour necrosis factor-alpha and oncolytic vaccinia virus improves tumour targeting and prolongs survival in a rat model of advanced extremity sarcoma.

Pencavel TD, Wilkinson MJ, Mansfield DC, Khan AA, Seth R, Karapanagiotou EM, Roulstone V, Aguilar RJ, Chen NG, Szalay AA, Hayes AJ, Harrington KJ.

Int J Cancer. 2015 Feb 15;136(4):965-76. doi: 10.1002/ijc.29059. Epub 2014 Jul 22.


Oncolytic immunotherapy using recombinant vaccinia virus GLV-1h68 kills sorafenib-resistant hepatocellular carcinoma efficiently.

Ady JW, Heffner J, Mojica K, Johnsen C, Belin LJ, Love D, Chen CT, Pugalenthi A, Klein E, Chen NG, Yu YA, Szalay AA, Fong Y.

Surgery. 2014 Aug;156(2):263-9. doi: 10.1016/j.surg.2014.03.031. Epub 2014 Jun 21.


Characterization of metastasis formation and virotherapy in the human C33A cervical cancer model.

Donat U, Rother J, Schäfer S, Hess M, Härtl B, Kober C, Langbein-Laugwitz J, Stritzker J, Chen NG, Aguilar RJ, Weibel S, Szalay AA.

PLoS One. 2014 Jun 2;9(6):e98533. doi: 10.1371/journal.pone.0098533. eCollection 2014.


Oncolytic virotherapy of canine and feline cancer.

Gentschev I, Patil SS, Petrov I, Cappello J, Adelfinger M, Szalay AA.

Viruses. 2014 May 16;6(5):2122-37. doi: 10.3390/v6052122. Review.


Biotherapeutic approaches to target cancer stem cells.

Duggal R, Minev B, Geissinger U, Wang H, Chen NG, Koka PS, Szalay AA.

J Stem Cells. 2013;8(3-4):135-49. doi: jsc.2014.8.3/4.135. Review.


PEG-pHPMAm-based polymeric micelles loaded with doxorubicin-prodrugs in combination antitumor therapy with oncolytic vaccinia viruses.

Ruiz-Hernández E, Hess M, Melen GJ, Theek B, Talelli M, Shi Y, Ozbakir B, Teunissen EA, Ramírez M, Moeckel D, Kiessling F, Storm G, Scheeren HW, Hennink WE, Szalay AA, Stritzker J, Lammers T.

Polym Chem. 2014 Mar 7;(5):1674-1681.


Oncolytic vaccinia virus in combination with radiation shows synergistic antitumor efficacy in pancreatic cancer.

Dai MH, Liu SL, Chen NG, Zhang TP, You L, Q Zhang F, Chou TC, Szalay AA, Fong Y, Zhao YP.

Cancer Lett. 2014 Mar 28;344(2):282-90. doi: 10.1016/j.canlet.2013.11.007. Epub 2013 Dec 7.


Vaccinia virus GLV-1h153 in combination with 131I shows increased efficiency in treating triple-negative breast cancer.

Gholami S, Chen CH, Lou E, Belin LJ, Fujisawa S, Longo VA, Chen NG, Gönen M, Zanzonico PB, Szalay AA, Fong Y.

FASEB J. 2014 Feb;28(2):676-82. doi: 10.1096/fj.13-237222. Epub 2013 Nov 1.

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