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Results: 1 to 20 of 107


Innate immune perturbations, accumulating DAMPs and inflammasome dysregulation: A ticking time bomb in ageing.

Kapetanovic R, Bokil NJ, Sweet MJ.

Ageing Res Rev. 2015 Feb 25. pii: S1568-1637(15)00028-8. doi: 10.1016/j.arr.2015.02.005. [Epub ahead of print] Review.


Senescent human hepatocytes express a unique secretory phenotype and promote macrophage migration.

Irvine KM, Skoien R, Bokil NJ, Melino M, Thomas GP, Loo D, Gabrielli B, Hill MM, Sweet MJ, Clouston AD, Powell EE.

World J Gastroenterol. 2014 Dec 21;20(47):17851-62. doi: 10.3748/wjg.v20.i47.17851.


The co-transcriptome of uropathogenic Escherichia coli-infected mouse macrophages reveals new insights into host-pathogen interactions.

Mavromatis CH, Bokil NJ, Totsika M, Kakkanat A, Schaale K, Cannistraci CV, Ryu T, Beatson SA, Ulett GC, Schembri MA, Sweet MJ, Ravasi T.

Cell Microbiol. 2015 May;17(5):730-46. doi: 10.1111/cmi.12397. Epub 2015 Jan 24.


Receptor-interacting protein kinase 4 and interferon regulatory factor 6 function as a signaling axis to regulate keratinocyte differentiation.

Kwa MQ, Huynh J, Aw J, Zhang L, Nguyen T, Reynolds EC, Sweet MJ, Hamilton JA, Scholz GM.

J Biol Chem. 2014 Nov 7;289(45):31077-87. doi: 10.1074/jbc.M114.589382. Epub 2014 Sep 22.


The neutrophil NLRC4 inflammasome selectively promotes IL-1β maturation without pyroptosis during acute Salmonella challenge.

Chen KW, Groß CJ, Sotomayor FV, Stacey KJ, Tschopp J, Sweet MJ, Schroder K.

Cell Rep. 2014 Jul 24;8(2):570-82. doi: 10.1016/j.celrep.2014.06.028. Epub 2014 Jul 17.


Rab8a interacts directly with PI3Kγ to modulate TLR4-driven PI3K and mTOR signalling.

Luo L, Wall AA, Yeo JC, Condon ND, Norwood SJ, Schoenwaelder S, Chen KW, Jackson S, Jenkins BJ, Hartland EL, Schroder K, Collins BM, Sweet MJ, Stow JL.

Nat Commun. 2014 Jul 15;5:4407. doi: 10.1038/ncomms5407.


Experimental antibiotic treatment identifies potential pathogens of white band disease in the endangered Caribbean coral Acropora cervicornis.

Sweet MJ, Croquer A, Bythell JC.

Proc Biol Sci. 2014 Aug 7;281(1788):20140094. doi: 10.1098/rspb.2014.0094.


Interferon regulatory factor 6 differentially regulates Toll-like receptor 2-dependent chemokine gene expression in epithelial cells.

Kwa MQ, Nguyen T, Huynh J, Ramnath D, De Nardo D, Lam PY, Reynolds EC, Hamilton JA, Sweet MJ, Scholz GM.

J Biol Chem. 2014 Jul 11;289(28):19758-68. doi: 10.1074/jbc.M114.584540. Epub 2014 May 28.


Towards selective lysophospholipid GPCR modulators.

Archbold JK, Martin JL, Sweet MJ.

Trends Pharmacol Sci. 2014 May;35(5):219-26. doi: 10.1016/ Epub 2014 Apr 16.


Tumor cell-expressed SerpinB2 is present on microparticles and inhibits metastasis.

Schroder WA, Major LD, Le TT, Gardner J, Sweet MJ, Janciauskiene S, Suhrbier A.

Cancer Med. 2014 Jun;3(3):500-13. doi: 10.1002/cam4.229. Epub 2014 Mar 19.


Recombinant Wnt3a and Wnt5a elicit macrophage cytokine production and tolerization to microbial stimulation via Toll-like receptor 4.

Yu CH, Nguyen TT, Irvine KM, Sweet MJ, Frazer IH, Blumenthal A.

Eur J Immunol. 2014 May;44(5):1480-90. doi: 10.1002/eji.201343959. Epub 2014 Mar 7.


Protective role for Toll-like receptor-9 in the development of atherosclerosis in apolipoprotein E-deficient mice.

Koulis C, Chen YC, Hausding C, Ahrens I, Kyaw TS, Tay C, Allen T, Jandeleit-Dahm K, Sweet MJ, Akira S, Bobik A, Peter K, Agrotis A.

Arterioscler Thromb Vasc Biol. 2014 Mar;34(3):516-25. doi: 10.1161/ATVBAHA.113.302407. Epub 2014 Jan 16.


The TLR signalling adaptor TRIF/TICAM-1 has an N-terminal helical domain with structural similarity to IFIT proteins.

Ullah MO, Ve T, Mangan M, Alaidarous M, Sweet MJ, Mansell A, Kobe B.

Acta Crystallogr D Biol Crystallogr. 2013 Dec;69(Pt 12):2420-30. doi: 10.1107/S0907444913022385. Epub 2013 Nov 19.


Mechanism of bacterial interference with TLR4 signaling by Brucella Toll/interleukin-1 receptor domain-containing protein TcpB.

Alaidarous M, Ve T, Casey LW, Valkov E, Ericsson DJ, Ullah MO, Schembri MA, Mansell A, Sweet MJ, Kobe B.

J Biol Chem. 2014 Jan 10;289(2):654-68. doi: 10.1074/jbc.M113.523274. Epub 2013 Nov 21.


Cloning, expression, purification, crystallization and preliminary X-ray crystallographic analysis of the TIR domain from the Brucella melitensis TIR-domain-containing protein TcpB.

Alaidarous M, Ve T, Ullah MO, Valkov E, Mansell A, Schembri MA, Sweet MJ, Kobe B.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Oct;69(Pt 10):1167-70. doi: 10.1107/S1744309113024408. Epub 2013 Sep 28.


Inflammatory responses induced by lipopolysaccharide are amplified in primary human monocytes but suppressed in macrophages by complement protein C5a.

Seow V, Lim J, Iyer A, Suen JY, Ariffin JK, Hohenhaus DM, Sweet MJ, Fairlie DP.

J Immunol. 2013 Oct 15;191(8):4308-16. doi: 10.4049/jimmunol.1301355. Epub 2013 Sep 16.


An mRNA atlas of G protein-coupled receptor expression during primary human monocyte/macrophage differentiation and lipopolysaccharide-mediated activation identifies targetable candidate regulators of inflammation.

Hohenhaus DM, Schaale K, Le Cao KA, Seow V, Iyer A, Fairlie DP, Sweet MJ.

Immunobiology. 2013 Nov;218(11):1345-53. doi: 10.1016/j.imbio.2013.07.001. Epub 2013 Jul 15.


Algae as reservoirs for coral pathogens.

Sweet MJ, Bythell JC, Nugues MM.

PLoS One. 2013 Jul 31;8(7):e69717. doi: 10.1371/journal.pone.0069717. Print 2013.


Histone deacetylase 7 promotes Toll-like receptor 4-dependent proinflammatory gene expression in macrophages.

Shakespear MR, Hohenhaus DM, Kelly GM, Kamal NA, Gupta P, Labzin LI, Schroder K, Garceau V, Barbero S, Iyer A, Hume DA, Reid RC, Irvine KM, Fairlie DP, Sweet MJ.

J Biol Chem. 2013 Aug 30;288(35):25362-74. doi: 10.1074/jbc.M113.496281. Epub 2013 Jul 12.


Crystallization and X-ray diffraction analysis of the N-terminal domain of the Toll-like receptor signalling adaptor protein TRIF/TICAM-1.

Ullah MO, Ve T, Dkhar J, Alaidarous M, Ericsson DJ, Sweet MJ, Mansell A, Kobe B.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Jul;69(Pt 7):766-70. doi: 10.1107/S174430911301419X. Epub 2013 Jun 28.

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