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Inhibitors of Mycobacterium tuberculosis EgtD target both substrate binding sites to limit hercynine production.
Sci Rep. 2021 Nov 15;11(1):22240. doi: 10.1038/s41598-021-01526-6.
Sci Rep. 2021.
PMID: 34782676
Free PMC article.
Characterization of Tetrahydrolipstatin and Stereoderivatives on the Inhibition of Essential Mycobacterium tuberculosis Lipid Esterases.
Goins CM, Sudasinghe TD, Liu X, Wang Y, O'Doherty GA, Ronning DR.
Goins CM, et al. Among authors: sudasinghe td.
Biochemistry. 2018 Apr 24;57(16):2383-2393. doi: 10.1021/acs.biochem.8b00152. Epub 2018 Apr 10.
Biochemistry. 2018.
PMID: 29601187
Free PMC article.
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Total Synthesis of Tetrahydrolipstatin, Its Derivatives, and Evaluation of Their Ability to Potentiate Multiple Antibiotic Classes against Mycobacterium Species.
Khan SS, Sudasinghe TD, Landgraf AD, Ronning DR, Sucheck SJ.
Khan SS, et al. Among authors: sudasinghe td.
ACS Infect Dis. 2021 Oct 8;7(10):2876-2888. doi: 10.1021/acsinfecdis.1c00283. Epub 2021 Sep 3.
ACS Infect Dis. 2021.
PMID: 34478259
Free PMC article.
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