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Items: 1 to 20 of 188


Targeted drug delivery to ischemic stroke via chlorotoxin-anchored, lexiscan-loaded nanoparticles.

Han L, Cai Q, Tian D, Kong DK, Gou X, Chen Z, Strittmatter SM, Wang Z, Sheth KN, Zhou J.

Nanomedicine. 2016 Mar 30. pii: S1549-9634(16)30018-1. doi: 10.1016/j.nano.2016.03.005. [Epub ahead of print]


Metabotropic glutamate receptor 5 couples cellular prion protein to intracellular signalling in Alzheimer's disease.

Haas LT, Salazar SV, Kostylev MA, Um JW, Kaufman AC, Strittmatter SM.

Brain. 2016 Feb;139(Pt 2):526-46. doi: 10.1093/brain/awv356. Epub 2015 Dec 14.


Erasure of fear memories is prevented by Nogo Receptor 1 in adulthood.

Bhagat SM, Butler SS, Taylor JR, McEwen BS, Strittmatter SM.

Mol Psychiatry. 2015 Dec 1. doi: 10.1038/mp.2015.179. [Epub ahead of print]


Comprehensive Corticospinal Labeling with mu-crystallin Transgene Reveals Axon Regeneration after Spinal Cord Trauma in ngr1-/- Mice.

Fink KL, Strittmatter SM, Cafferty WB.

J Neurosci. 2015 Nov 18;35(46):15403-18. doi: 10.1523/JNEUROSCI.3165-15.2015.


Gene-Silencing Screen for Mammalian Axon Regeneration Identifies Inpp5f (Sac2) as an Endogenous Suppressor of Repair after Spinal Cord Injury.

Zou Y, Stagi M, Wang X, Yigitkanli K, Siegel CS, Nakatsu F, Cafferty WB, Strittmatter SM.

J Neurosci. 2015 Jul 22;35(29):10429-39. doi: 10.1523/JNEUROSCI.1718-15.2015.


Prion-Protein-interacting Amyloid-β Oligomers of High Molecular Weight Are Tightly Correlated with Memory Impairment in Multiple Alzheimer Mouse Models.

Kostylev MA, Kaufman AC, Nygaard HB, Patel P, Haas LT, Gunther EC, Vortmeyer A, Strittmatter SM.

J Biol Chem. 2015 Jul 10;290(28):17415-38. doi: 10.1074/jbc.M115.643577. Epub 2015 May 27.


Brivaracetam, but not ethosuximide, reverses memory impairments in an Alzheimer's disease mouse model.

Nygaard HB, Kaufman AC, Sekine-Konno T, Huh LL, Going H, Feldman SJ, Kostylev MA, Strittmatter SM.

Alzheimers Res Ther. 2015 May 5;7(1):25. doi: 10.1186/s13195-015-0110-9. eCollection 2015.


A phase Ib multiple ascending dose study of the safety, tolerability, and central nervous system availability of AZD0530 (saracatinib) in Alzheimer's disease.

Nygaard HB, Wagner AF, Bowen GS, Good SP, MacAvoy MG, Strittmatter KA, Kaufman AC, Rosenberg BJ, Sekine-Konno T, Varma P, Chen K, Koleske AJ, Reiman EM, Strittmatter SM, van Dyck CH.

Alzheimers Res Ther. 2015 Apr 14;7(1):35. doi: 10.1186/s13195-015-0119-0. eCollection 2015.


Sac2/INPP5F is an inositol 4-phosphatase that functions in the endocytic pathway.

Nakatsu F, Messa M, Nández R, Czapla H, Zou Y, Strittmatter SM, De Camilli P.

J Cell Biol. 2015 Apr 13;209(1):85-95. doi: 10.1083/jcb.201409064.


Fyn inhibition rescues established memory and synapse loss in Alzheimer mice.

Kaufman AC, Salazar SV, Haas LT, Yang J, Kostylev MA, Jeng AT, Robinson SA, Gunther EC, van Dyck CH, Nygaard HB, Strittmatter SM.

Ann Neurol. 2015 Jun;77(6):953-71. doi: 10.1002/ana.24394. Epub 2015 Mar 21.


Intravitreal delivery of human NgR-Fc decoy protein regenerates axons after optic nerve crush and protects ganglion cells in glaucoma models.

Wang X, Lin J, Arzeno A, Choi JY, Boccio J, Frieden E, Bhargava A, Maynard G, Tsai JC, Strittmatter SM.

Invest Ophthalmol Vis Sci. 2015 Feb 5;56(2):1357-66. doi: 10.1167/iovs.14-15472.


Plasticity of intact rubral projections mediates spontaneous recovery of function after corticospinal tract injury.

Siegel CS, Fink KL, Strittmatter SM, Cafferty WB.

J Neurosci. 2015 Jan 28;35(4):1443-57. doi: 10.1523/JNEUROSCI.3713-14.2015.


Progressive retinal degeneration and accumulation of autofluorescent lipopigments in Progranulin deficient mice.

Hafler BP, Klein ZA, Jimmy Zhou Z, Strittmatter SM.

Brain Res. 2014 Nov 7;1588:168-74. doi: 10.1016/j.brainres.2014.09.023. Epub 2014 Sep 16.


Therapeutic molecules and endogenous ligands regulate the interaction between brain cellular prion protein (PrPC) and metabotropic glutamate receptor 5 (mGluR5).

Haas LT, Kostylev MA, Strittmatter SM.

J Biol Chem. 2014 Oct 10;289(41):28460-77. doi: 10.1074/jbc.M114.584342. Epub 2014 Aug 22.


Lysosome size, motility and stress response regulated by fronto-temporal dementia modifier TMEM106B.

Stagi M, Klein ZA, Gould TJ, Bewersdorf J, Strittmatter SM.

Mol Cell Neurosci. 2014 Jul;61:226-40. doi: 10.1016/j.mcn.2014.07.006. Epub 2014 Jul 24.


Human NgR-Fc decoy protein via lumbar intrathecal bolus administration enhances recovery from rat spinal cord contusion.

Wang X, Yigitkanli K, Kim CY, Sekine-Komo T, Wirak D, Frieden E, Bhargava A, Maynard G, Cafferty WB, Strittmatter SM.

J Neurotrauma. 2014 Dec 15;31(24):1955-66. doi: 10.1089/neu.2014.3355. Epub 2014 Oct 16.


The Nogo receptor NgR1 mediates infection by mammalian reovirus.

Konopka-Anstadt JL, Mainou BA, Sutherland DM, Sekine Y, Strittmatter SM, Dermody TS.

Cell Host Microbe. 2014 Jun 11;15(6):681-91. doi: 10.1016/j.chom.2014.05.010.


Overcoming Drug Development Bottlenecks With Repurposing: Old drugs learn new tricks.

Strittmatter SM.

Nat Med. 2014 Jun;20(6):590-1. doi: 10.1038/nm.3595. No abstract available.


Diffusion tensor imaging as a predictor of locomotor function after experimental spinal cord injury and recovery.

Kelley BJ, Harel NY, Kim CY, Papademetris X, Coman D, Wang X, Hasan O, Kaufman A, Globinsky R, Staib LH, Cafferty WB, Hyder F, Strittmatter SM.

J Neurotrauma. 2014 Aug 1;31(15):1362-73. doi: 10.1089/neu.2013.3238. Epub 2014 Jul 8.


Nogo limits neural plasticity and recovery from injury.

Schwab ME, Strittmatter SM.

Curr Opin Neurobiol. 2014 Aug;27:53-60. doi: 10.1016/j.conb.2014.02.011. Epub 2014 Mar 12. Review.

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