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Harnessing the Endocannabinoid 2-Arachidonoylglycerol to Lower Intraocular Pressure in a Murine Model.

Miller S, Leishman E, Hu SS, Elghouche A, Daily L, Murataeva N, Bradshaw H, Straiker A.

Invest Ophthalmol Vis Sci. 2016 Jun 1;57(7):3287-96. doi: 10.1167/iovs.16-19356.


Where's my entourage? The curious case of 2-oleoylglycerol, 2-linolenoylglycerol, and 2-palmitoylglycerol.

Murataeva N, Dhopeshwarkar A, Yin D, Mitjavila J, Bradshaw H, Straiker A, Mackie K.

Pharmacol Res. 2016 Aug;110:173-80. doi: 10.1016/j.phrs.2016.04.015. Epub 2016 Apr 23.


Broad impact of deleting endogenous cannabinoid hydrolyzing enzymes and the CB1 cannabinoid receptor on the endogenous cannabinoid-related lipidome in eight regions of the mouse brain.

Leishman E, Cornett B, Spork K, Straiker A, Mackie K, Bradshaw HB.

Pharmacol Res. 2016 Aug;110:159-72. doi: 10.1016/j.phrs.2016.04.020. Epub 2016 Apr 22.


Aiming for allosterism: Evaluation of allosteric modulators of CB1 in a neuronal model.

Straiker A, Mitjavila J, Yin D, Gibson A, Mackie K.

Pharmacol Res. 2015 Sep;99:370-6. doi: 10.1016/j.phrs.2015.07.017. Epub 2015 Jul 23.


Cannabinoid-induced chemotaxis in bovine corneal epithelial cells.

Murataeva N, Li S, Oehler O, Miller S, Dhopeshwarkar A, Hu SS, Bonanno JA, Bradshaw H, Mackie K, McHugh D, Straiker A.

Invest Ophthalmol Vis Sci. 2015 May;56(5):3304-13. doi: 10.1167/iovs.14-15675.


Cannabinoid receptor-interacting protein 1a modulates CB1 receptor signaling and regulation.

Smith TH, Blume LC, Straiker A, Cox JO, David BG, McVoy JR, Sayers KW, Poklis JL, Abdullah RA, Egertová M, Chen CK, Mackie K, Elphick MR, Howlett AC, Selley DE.

Mol Pharmacol. 2015 Apr;87(4):747-65. doi: 10.1124/mol.114.096495. Epub 2015 Feb 5.


AM841, a covalent cannabinoid ligand, powerfully slows gastrointestinal motility in normal and stressed mice in a peripherally restricted manner.

Keenan CM, Storr MA, Thakur GA, Wood JT, Wager-Miller J, Straiker A, Eno MR, Nikas SP, Bashashati M, Hu H, Mackie K, Makriyannis A, Sharkey KA.

Br J Pharmacol. 2015 May;172(9):2406-18. doi: 10.1111/bph.13069. Epub 2015 Feb 27.


Cannabinoid and lipid-mediated vasorelaxation in retinal microvasculature.

MacIntyre J, Dong A, Straiker A, Zhu J, Howlett SE, Bagher A, Denovan-Wright E, Yu DY, Kelly ME.

Eur J Pharmacol. 2014 Jul 15;735:105-14. doi: 10.1016/j.ejphar.2014.03.055. Epub 2014 Apr 18.


Mutation of putative GRK phosphorylation sites in the cannabinoid receptor 1 (CB1R) confers resistance to cannabinoid tolerance and hypersensitivity to cannabinoids in mice.

Morgan DJ, Davis BJ, Kearn CS, Marcus D, Cook AJ, Wager-Miller J, Straiker A, Myoga MH, Karduck J, Leishman E, Sim-Selley LJ, Czyzyk TA, Bradshaw HB, Selley DE, Mackie K.

J Neurosci. 2014 Apr 9;34(15):5152-63. doi: 10.1523/JNEUROSCI.3445-12.2014.


Parsing the players: 2-arachidonoylglycerol synthesis and degradation in the CNS.

Murataeva N, Straiker A, Mackie K.

Br J Pharmacol. 2014 Mar;171(6):1379-91. doi: 10.1111/bph.12411. Review.


Diacylglycerol lipaseα (DAGLα) and DAGLβ cooperatively regulate the production of 2-arachidonoyl glycerol in autaptic hippocampal neurons.

Jain T, Wager-Miller J, Mackie K, Straiker A.

Mol Pharmacol. 2013 Aug;84(2):296-302. doi: 10.1124/mol.113.085217. Epub 2013 Jun 7.


Fmr1 deletion enhances and ultimately desensitizes CB(1) signaling in autaptic hippocampal neurons.

Straiker A, Min KT, Mackie K.

Neurobiol Dis. 2013 Aug;56:1-5. doi: 10.1016/j.nbd.2013.04.002. Epub 2013 Apr 9.


GPR55, a G-protein coupled receptor for lysophosphatidylinositol, plays a role in motor coordination.

Wu CS, Chen H, Sun H, Zhu J, Jew CP, Wager-Miller J, Straiker A, Spencer C, Bradshaw H, Mackie K, Lu HC.

PLoS One. 2013;8(4):e60314. doi: 10.1371/journal.pone.0060314. Epub 2013 Apr 2.


A GPR18-based signalling system regulates IOP in murine eye.

Caldwell MD, Hu SS, Viswanathan S, Bradshaw H, Kelly ME, Straiker A.

Br J Pharmacol. 2013 Jun;169(4):834-43. doi: 10.1111/bph.12136.


The CB2-preferring agonist JWH015 also potently and efficaciously activates CB1 in autaptic hippocampal neurons.

Murataeva N, Mackie K, Straiker A.

Pharmacol Res. 2012 Nov;66(5):437-42. doi: 10.1016/j.phrs.2012.08.002. Epub 2012 Aug 14.


CB₂ cannabinoid receptors inhibit synaptic transmission when expressed in cultured autaptic neurons.

Atwood BK, Straiker A, Mackie K.

Neuropharmacology. 2012 Sep;63(4):514-23. doi: 10.1016/j.neuropharm.2012.04.024. Epub 2012 May 8.


Sticking out of the crowd: the molecular identity and development of cholecystokinin-containing basket cells.

Keimpema E, Straiker A, Mackie K, Harkany T, Hjerling-Leffler J.

J Physiol. 2012 Feb 15;590(4):703-14. doi: 10.1113/jphysiol.2011.224386. Epub 2012 Jan 4. Review.


CB₂: therapeutic target-in-waiting.

Atwood BK, Straiker A, Mackie K.

Prog Neuropsychopharmacol Biol Psychiatry. 2012 Jul 2;38(1):16-20. doi: 10.1016/j.pnpbp.2011.12.001. Epub 2011 Dec 9. Review.


The endocannabinoid N-arachidonoyldopamine (NADA) exerts neuroprotective effects after excitotoxic neuronal damage via cannabinoid receptor 1 (CB(1)).

Grabiec U, Koch M, Kallendrusch S, Kraft R, Hill K, Merkwitz C, Ghadban C, Lutz B, Straiker A, Dehghani F.

Neuropharmacology. 2012 Mar;62(4):1797-807. doi: 10.1016/j.neuropharm.2011.11.023. Epub 2011 Dec 13.


Functional selectivity in CB(2) cannabinoid receptor signaling and regulation: implications for the therapeutic potential of CB(2) ligands.

Atwood BK, Wager-Miller J, Haskins C, Straiker A, Mackie K.

Mol Pharmacol. 2012 Feb;81(2):250-63. doi: 10.1124/mol.111.074013. Epub 2011 Nov 7.

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