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Items: 1 to 20 of 282

1.

Elongation factor 4 remodels the A-site tRNA on the ribosome.

Gagnon MG, Lin J, Steitz TA.

Proc Natl Acad Sci U S A. 2016 May 3;113(18):4994-9. doi: 10.1073/pnas.1522932113. Epub 2016 Apr 18.

2.

Insights into RNA binding by the anticancer drug cisplatin from the crystal structure of cisplatin-modified ribosome.

Melnikov SV, Söll D, Steitz TA, Polikanov YS.

Nucleic Acids Res. 2016 Jun 2;44(10):4978-87. doi: 10.1093/nar/gkw246. Epub 2016 Apr 13.

3.

Structures of E. coli σS-transcription initiation complexes provide new insights into polymerase mechanism.

Liu B, Zuo Y, Steitz TA.

Proc Natl Acad Sci U S A. 2016 Apr 12;113(15):4051-6. doi: 10.1073/pnas.1520555113. Epub 2016 Mar 28.

4.

Structures of proline-rich peptides bound to the ribosome reveal a common mechanism of protein synthesis inhibition.

Gagnon MG, Roy RN, Lomakin IB, Florin T, Mankin AS, Steitz TA.

Nucleic Acids Res. 2016 Mar 18;44(5):2439-50. doi: 10.1093/nar/gkw018. Epub 2016 Jan 24.

5.

Antimicrobial peptides targeting bacterial ribosome.

Lomakin IB, Gagnon MG, Steitz TA.

Oncotarget. 2015 Aug 7;6(22):18744-5. No abstract available.

6.

Distinct tRNA Accommodation Intermediates Observed on the Ribosome with the Antibiotics Hygromycin A and A201A.

Polikanov YS, Starosta AL, Juette MF, Altman RB, Terry DS, Lu W, Burnett BJ, Dinos G, Reynolds KA, Blanchard SC, Steitz TA, Wilson DN.

Mol Cell. 2015 Jun 4;58(5):832-44. doi: 10.1016/j.molcel.2015.04.014. Epub 2015 May 28.

7.

The mechanism of inhibition of protein synthesis by the proline-rich peptide oncocin.

Roy RN, Lomakin IB, Gagnon MG, Steitz TA.

Nat Struct Mol Biol. 2015 Jun;22(6):466-9. doi: 10.1038/nsmb.3031. Epub 2015 May 18.

8.

Crystal structures of the E. coli transcription initiation complexes with a complete bubble.

Zuo Y, Steitz TA.

Mol Cell. 2015 May 7;58(3):534-40. doi: 10.1016/j.molcel.2015.03.010. Epub 2015 Apr 9.

9.

Structural insights into the role of rRNA modifications in protein synthesis and ribosome assembly.

Polikanov YS, Melnikov SV, Söll D, Steitz TA.

Nat Struct Mol Biol. 2015 Apr;22(4):342-4. doi: 10.1038/nsmb.2992. Epub 2015 Mar 16.

10.

Crystal Structure of Human Profilaggrin S100 Domain and Identification of Target Proteins Annexin II, Stratifin, and HSP27.

Bunick CG, Presland RB, Lawrence OT, Pearton DJ, Milstone LM, Steitz TA.

J Invest Dermatol. 2015 Jul;135(7):1801-9. doi: 10.1038/jid.2015.102. Epub 2015 Mar 11.

11.

Structural basis for transcription reactivation by RapA.

Liu B, Zuo Y, Steitz TA.

Proc Natl Acad Sci U S A. 2015 Feb 17;112(7):2006-10. doi: 10.1073/pnas.1417152112. Epub 2015 Feb 2.

12.

Conformational changes of elongation factor G on the ribosome during tRNA translocation.

Lin J, Gagnon MG, Bulkley D, Steitz TA.

Cell. 2015 Jan 15;160(1-2):219-27. doi: 10.1016/j.cell.2014.11.049.

13.

Polyspecific pyrrolysyl-tRNA synthetases from directed evolution.

Guo LT, Wang YS, Nakamura A, Eiler D, Kavran JM, Wong M, Kiessling LL, Steitz TA, O'Donoghue P, Söll D.

Proc Natl Acad Sci U S A. 2014 Nov 25;111(47):16724-9. doi: 10.1073/pnas.1419737111. Epub 2014 Nov 10.

14.

Negamycin interferes with decoding and translocation by simultaneous interaction with rRNA and tRNA.

Polikanov YS, Szal T, Jiang F, Gupta P, Matsuda R, Shiozuka M, Steitz TA, Vázquez-Laslop N, Mankin AS.

Mol Cell. 2014 Nov 20;56(4):541-50. doi: 10.1016/j.molcel.2014.09.021. Epub 2014 Oct 9.

15.

Amicoumacin a inhibits translation by stabilizing mRNA interaction with the ribosome.

Polikanov YS, Osterman IA, Szal T, Tashlitsky VN, Serebryakova MV, Kusochek P, Bulkley D, Malanicheva IA, Efimenko TA, Efremenkova OV, Konevega AL, Shaw KJ, Bogdanov AA, Rodnina MV, Dontsova OA, Mankin AS, Steitz TA, Sergiev PV.

Mol Cell. 2014 Nov 20;56(4):531-40. doi: 10.1016/j.molcel.2014.09.020. Epub 2014 Oct 9.

16.

Structural basis for the fast self-cleavage reaction catalyzed by the twister ribozyme.

Eiler D, Wang J, Steitz TA.

Proc Natl Acad Sci U S A. 2014 Sep 9;111(36):13028-33. doi: 10.1073/pnas.1414571111. Epub 2014 Aug 25.

17.

A proton wire to couple aminoacyl-tRNA accommodation and peptide-bond formation on the ribosome.

Polikanov YS, Steitz TA, Innis CA.

Nat Struct Mol Biol. 2014 Sep;21(9):787-93. doi: 10.1038/nsmb.2871. Epub 2014 Aug 17.

18.

Crystal structure of elongation factor 4 bound to a clockwise ratcheted ribosome.

Gagnon MG, Lin J, Bulkley D, Steitz TA.

Science. 2014 Aug 8;345(6197):684-7. doi: 10.1126/science.1253525.

19.

Structural insights into the stabilization of MALAT1 noncoding RNA by a bipartite triple helix.

Brown JA, Bulkley D, Wang J, Valenstein ML, Yario TA, Steitz TA, Steitz JA.

Nat Struct Mol Biol. 2014 Jul;21(7):633-40. doi: 10.1038/nsmb.2844. Epub 2014 Jun 22.

20.

Exploiting large non-isomorphous differences for phase determination of a G-segment invertase-DNA complex.

Ritacco CJ, Steitz TA, Wang J.

Acta Crystallogr D Biol Crystallogr. 2014 Mar;70(Pt 3):685-93. doi: 10.1107/S1399004713032392. Epub 2014 Feb 15.

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