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Alexidine Dihydrochloride Attenuates Osteoclast Formation and Bone Resorption and Protects Against LPS-Induced Osteolysis.

Zhu X, Gao J, Ng PY, Qin A, Steer JH, Pavlos NJ, Zheng MH, Dong Y, Cheng TS.

J Bone Miner Res. 2015 Sep 12. doi: 10.1002/jbmr.2710. [Epub ahead of print]


Early induction of uncoupling protein-2 in pulmonary macrophages in hyperoxia-associated lung injury.

Steer JH, Mann TS, Lo SZ, Inglis JJ, Yap HS, Henry PJ, Joyce DA.

Inhal Toxicol. 2013 Aug;25(9):544-52. doi: 10.3109/08958378.2013.810679.


Paclitaxel inhibits osteoclast formation and bone resorption via influencing mitotic cell cycle arrest and RANKL-induced activation of NF-κB and ERK.

Ang ES, Pavlos NJ, Chim SM, Feng HT, Scaife RM, Steer JH, Zheng MH, Xu J.

J Cell Biochem. 2012 Mar;113(3):946-55. doi: 10.1002/jcb.23423.


TNF-α renders macrophages resistant to a range of cancer chemotherapeutic agents through NF-κB-mediated antagonism of apoptosis signalling.

Lo SZ, Steer JH, Joyce DA.

Cancer Lett. 2011 Aug 1;307(1):80-92. doi: 10.1016/j.canlet.2011.03.020. Epub 2011 Apr 11.


Tumor necrosis factor-alpha promotes survival in methotrexate-exposed macrophages by an NF-kappaB-dependent pathway.

Lo SZ, Steer JH, Joyce DA.

Arthritis Res Ther. 2011 Feb 15;13(1):R24. doi: 10.1186/ar3248.


c-Cbl promotes T cell receptor-induced thymocyte apoptosis by activating the phosphatidylinositol 3-kinase/Akt pathway.

Thien CB, Dagger SA, Steer JH, Koentgen F, Jansen ES, Scott CL, Langdon WY.

J Biol Chem. 2010 Apr 2;285(14):10969-81. doi: 10.1074/jbc.M109.094920. Epub 2010 Feb 4.


Caffeic acid phenethyl ester, an active component of honeybee propolis attenuates osteoclastogenesis and bone resorption via the suppression of RANKL-induced NF-kappaB and NFAT activity.

Ang ES, Pavlos NJ, Chai LY, Qi M, Cheng TS, Steer JH, Joyce DA, Zheng MH, Xu J.

J Cell Physiol. 2009 Dec;221(3):642-9. doi: 10.1002/jcp.21898.


Myocyte enhancer factor 2 and microphthalmia-associated transcription factor cooperate with NFATc1 to transactivate the V-ATPase d2 promoter during RANKL-induced osteoclastogenesis.

Feng H, Cheng T, Steer JH, Joyce DA, Pavlos NJ, Leong C, Kular J, Liu J, Feng X, Zheng MH, Xu J.

J Biol Chem. 2009 May 22;284(21):14667-76. doi: 10.1074/jbc.M901670200. Epub 2009 Mar 25.


Uncoupling protein-2 accumulates rapidly in the inner mitochondrial membrane during mitochondrial reactive oxygen stress in macrophages.

Giardina TM, Steer JH, Lo SZ, Joyce DA.

Biochim Biophys Acta. 2008 Feb;1777(2):118-29. Epub 2007 Nov 22.


Oxidative stress causes a decline in lysosomal integrity during hypothermic incubation of rat hepatocytes.

Arthur PG, Niu X, Rigby P, Steer JH, Jeffrey GP.

Free Radic Biol Med. 2008 Jan 1;44(1):24-33. Epub 2007 Sep 19.


Monocyte-derived macrophages from men and women with Type 2 diabetes mellitus differ in fatty acid composition compared with non-diabetic controls.

Senanayake S, Brownrigg LM, Panicker V, Croft KD, Joyce DA, Steer JH, Puddey IB, Yeap BB.

Diabetes Res Clin Pract. 2007 Mar;75(3):292-300. Epub 2006 Sep 5.


Luminescence studies of the intracellular distribution of a dinuclear gold(I) N-heterocyclic carbene complex.

Barnard PJ, Wedlock LE, Baker MV, Berners-Price SJ, Joyce DA, Skelton BW, Steer JH.

Angew Chem Int Ed Engl. 2006 Sep 11;45(36):5966-70. No abstract available.


A novel mutation (K378X) in the sequestosome 1 gene associated with increased NF-kappaB signaling and Paget's disease of bone with a severe phenotype.

Rea SL, Walsh JP, Ward L, Yip K, Ward BK, Kent GN, Steer JH, Xu J, Ratajczak T.

J Bone Miner Res. 2006 Jul;21(7):1136-45.


Moraxella catarrhalis stimulates the release of proinflammatory cytokines and prostaglandin E from human respiratory epithelial cells and monocyte-derived macrophages.

Fink J, Mathaba LT, Stewart GA, Graham PT, Steer JH, Joyce DA, McWilliam AS.

FEMS Immunol Med Microbiol. 2006 Mar;46(2):198-208.


Altered expression of nuclear factor-kappaB in peripheral blood mononuclear cells in chronic haemodialysis patients.

Rangan GK, Kan G, Steer JH, Dogra G, Croft KD, Rhodes HC, Woodroffe AJ, Joyce DA.

Nephrol Dial Transplant. 2006 Apr;21(4):1137-9. Epub 2005 Dec 6. No abstract available.


Thapsigargin modulates osteoclastogenesis through the regulation of RANKL-induced signaling pathways and reactive oxygen species production.

Yip KH, Zheng MH, Steer JH, Giardina TM, Han R, Lo SZ, Bakker AJ, Cassady AI, Joyce DA, Xu J.

J Bone Miner Res. 2005 Aug;20(8):1462-71. Epub 2005 Mar 28.


Sesquiterpene lactone parthenolide blocks lipopolysaccharide-induced osteolysis through the suppression of NF-kappaB activity.

Yip KH, Zheng MH, Feng HT, Steer JH, Joyce DA, Xu J.

J Bone Miner Res. 2004 Nov;19(11):1905-16. Epub 2004 Sep 27.


Evidence of reciprocal regulation between the high extracellular calcium and RANKL signal transduction pathways in RAW cell derived osteoclasts.

Xu J, Wang C, Han R, Pavlos N, Phan T, Steer JH, Bakker AJ, Joyce DA, Zheng MH.

J Cell Physiol. 2005 Feb;202(2):554-62.


12-O-tetradecanoylphorbol-13-acetate (TPA) inhibits osteoclastogenesis by suppressing RANKL-induced NF-kappaB activation.

Wang C, Steer JH, Joyce DA, Yip KH, Zheng MH, Xu J.

J Bone Miner Res. 2003 Dec;18(12):2159-68.

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