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Items: 1 to 20 of 29


Distinct patterns of Cas9 mismatch tolerance in vitro and in vivo.

Fu BX, St Onge RP, Fire AZ, Smith JD.

Nucleic Acids Res. 2016 Jun 20;44(11):5365-77. doi: 10.1093/nar/gkw417. Epub 2016 May 19.


Quantitative CRISPR interference screens in yeast identify chemical-genetic interactions and new rules for guide RNA design.

Smith JD, Suresh S, Schlecht U, Wu M, Wagih O, Peltz G, Davis RW, Steinmetz LM, Parts L, St Onge RP.

Genome Biol. 2016 Mar 8;17:45. doi: 10.1186/s13059-016-0900-9.


Mitochondrial protein sorting as a therapeutic target for ATP synthase disorders.

Aiyar RS, Bohnert M, Duvezin-Caubet S, Voisset C, Gagneur J, Fritsch ES, Couplan E, von der Malsburg K, Funaya C, Soubigou F, Courtin F, Suresh S, Kucharczyk R, Evrard J, Antony C, St Onge RP, Blondel M, di Rago JP, van der Laan M, Steinmetz LM.

Nat Commun. 2014 Dec 18;5:5585. doi: 10.1038/ncomms6585.


Targeted and highly multiplexed detection of microorganisms by employing an ensemble of molecular probes.

Xu W, Krishnakumar S, Miranda M, Jensen MA, Fukushima M, Palm C, Fung E, Davis RW, St Onge RP, Hyman RW.

Appl Environ Microbiol. 2014 Jul;80(14):4153-61. doi: 10.1128/AEM.00666-14. Epub 2014 May 2.


Mapping the cellular response to small molecules using chemogenomic fitness signatures.

Lee AY, St Onge RP, Proctor MJ, Wallace IM, Nile AH, Spagnuolo PA, Jitkova Y, Gronda M, Wu Y, Kim MK, Cheung-Ong K, Torres NP, Spear ED, Han MK, Schlecht U, Suresh S, Duby G, Heisler LE, Surendra A, Fung E, Urbanus ML, Gebbia M, Lissina E, Miranda M, Chiang JH, Aparicio AM, Zeghouf M, Davis RW, Cherfils J, Boutry M, Kaiser CA, Cummins CL, Trimble WS, Brown GW, Schimmer AD, Bankaitis VA, Nislow C, Bader GD, Giaever G.

Science. 2014 Apr 11;344(6180):208-11. doi: 10.1126/science.1250217. Erratum in: Science. 2014 May 23;344(6186):1255771.


A functional screen for copper homeostasis genes identifies a pharmacologically tractable cellular system.

Schlecht U, Suresh S, Xu W, Aparicio AM, Chu A, Proctor MJ, Davis RW, Scharfe C, St Onge RP.

BMC Genomics. 2014 Apr 5;15:263. doi: 10.1186/1471-2164-15-263.


PITPs as targets for selectively interfering with phosphoinositide signaling in cells.

Nile AH, Tripathi A, Yuan P, Mousley CJ, Suresh S, Wallace IM, Shah SD, Pohlhaus DT, Temple B, Nislow C, Giaever G, Tropsha A, Davis RW, St Onge RP, Bankaitis VA.

Nat Chem Biol. 2014 Jan;10(1):76-84. doi: 10.1038/nchembio.1389. Epub 2013 Nov 24.


Cationic amphiphilic drugs are potent inhibitors of yeast sporulation.

Schlecht U, St Onge RP, Walther T, François JM, Davis RW.

PLoS One. 2012;7(8):e42853. doi: 10.1371/journal.pone.0042853. Epub 2012 Aug 8.


Multiplex assay for condition-dependent changes in protein-protein interactions.

Schlecht U, Miranda M, Suresh S, Davis RW, St Onge RP.

Proc Natl Acad Sci U S A. 2012 Jun 5;109(23):9213-8. doi: 10.1073/pnas.1204952109. Epub 2012 May 21.


Molecular probe technology detects bacteria without culture.

Hyman RW, St Onge RP, Kim H, Tamaresis JS, Miranda M, Aparicio AM, Fukushima M, Pourmand N, Giudice LC, Davis RW.

BMC Microbiol. 2012 Mar 9;12:29. doi: 10.1186/1471-2180-12-29.


Compound prioritization methods increase rates of chemical probe discovery in model organisms.

Wallace IM, Urbanus ML, Luciani GM, Burns AR, Han MK, Wang H, Arora K, Heisler LE, Proctor M, St Onge RP, Roemer T, Roy PJ, Cummins CL, Bader GD, Nislow C, Giaever G.

Chem Biol. 2011 Oct 28;18(10):1273-83. doi: 10.1016/j.chembiol.2011.07.018.


A yeast-based assay identifies drugs active against human mitochondrial disorders.

Couplan E, Aiyar RS, Kucharczyk R, Kabala A, Ezkurdia N, Gagneur J, St Onge RP, Salin B, Soubigou F, Le Cann M, Steinmetz LM, di Rago JP, Blondel M.

Proc Natl Acad Sci U S A. 2011 Jul 19;108(29):11989-94. doi: 10.1073/pnas.1101478108. Epub 2011 Jun 29.


The synthetic genetic interaction network reveals small molecules that target specific pathways in Sacchromyces cerevisiae.

Tamble CM, St Onge RP, Giaever G, Nislow C, Williams AG, Stuart JM, Lokey RS.

Mol Biosyst. 2011 Jun;7(6):2019-30. doi: 10.1039/c0mb00298d. Epub 2011 Apr 12.


Knocking out multigene redundancies via cycles of sexual assortment and fluorescence selection.

Suzuki Y, St Onge RP, Mani R, King OD, Heilbut A, Labunskyy VM, Chen W, Pham L, Zhang LV, Tong AH, Nislow C, Giaever G, Gladyshev VN, Vidal M, Schow P, Lehár J, Roth FP.

Nat Methods. 2011 Feb;8(2):159-64. doi: 10.1038/nmeth.1550. Epub 2011 Jan 9.


Gene annotation and drug target discovery in Candida albicans with a tagged transposon mutant collection.

Oh J, Fung E, Schlecht U, Davis RW, Giaever G, St Onge RP, Deutschbauer A, Nislow C.

PLoS Pathog. 2010 Oct 7;6(10):e1001140. doi: 10.1371/journal.ppat.1001140.


Exploring gene function and drug action using chemogenomic dosage assays.

Ericson E, Hoon S, St Onge RP, Giaever G, Nislow C.

Methods Enzymol. 2010;470:233-55. doi: 10.1016/S0076-6879(10)70010-0. Epub 2010 Mar 1.


Highly-multiplexed barcode sequencing: an efficient method for parallel analysis of pooled samples.

Smith AM, Heisler LE, St Onge RP, Farias-Hesson E, Wallace IM, Bodeau J, Harris AN, Perry KM, Giaever G, Pourmand N, Nislow C.

Nucleic Acids Res. 2010 Jul;38(13):e142. doi: 10.1093/nar/gkq368. Epub 2010 May 11.


Multiplex identification of microbes.

Hyman RW, St Onge RP, Allen EA, Miranda M, Aparicio AM, Fukushima M, Davis RW.

Appl Environ Microbiol. 2010 Jun;76(12):3904-10. doi: 10.1128/AEM.02785-09. Epub 2010 Apr 23.


The genetic landscape of a cell.

Costanzo M, Baryshnikova A, Bellay J, Kim Y, Spear ED, Sevier CS, Ding H, Koh JL, Toufighi K, Mostafavi S, Prinz J, St Onge RP, VanderSluis B, Makhnevych T, Vizeacoumar FJ, Alizadeh S, Bahr S, Brost RL, Chen Y, Cokol M, Deshpande R, Li Z, Lin ZY, Liang W, Marback M, Paw J, San Luis BJ, Shuteriqi E, Tong AH, van Dyk N, Wallace IM, Whitney JA, Weirauch MT, Zhong G, Zhu H, Houry WA, Brudno M, Ragibizadeh S, Papp B, Pál C, Roth FP, Giaever G, Nislow C, Troyanskaya OG, Bussey H, Bader GD, Gingras AC, Morris QD, Kim PM, Kaiser CA, Myers CL, Andrews BJ, Boone C.

Science. 2010 Jan 22;327(5964):425-31. doi: 10.1126/science.1180823.


Yeast chemical genomics and drug discovery: an update.

Hoon S, St Onge RP, Giaever G, Nislow C.

Trends Pharmacol Sci. 2008 Oct;29(10):499-504. doi: 10.1016/ Epub 2008 Aug 26. Review.

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