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Items: 19


Estrogen-induced chromatin decondensation and nuclear re-organization linked to regional epigenetic regulation in breast cancer.

Rafique S, Thomas JS, Sproul D, Bickmore WA.

Genome Biol. 2015 Aug 3;16:145. doi: 10.1186/s13059-015-0719-9.


FOXA1 repression is associated with loss of BRCA1 and increased promoter methylation and chromatin silencing in breast cancer.

Gong C, Fujino K, Monteiro LJ, Gomes AR, Drost R, Davidson-Smith H, Takeda S, Khoo US, Jonkers J, Sproul D, Lam EW.

Oncogene. 2015 Sep 24;34(39):5012-24. doi: 10.1038/onc.2014.421. Epub 2014 Dec 22.


Transcription factor binding predicts histone modifications in human cell lines.

Benveniste D, Sonntag HJ, Sanguinetti G, Sproul D.

Proc Natl Acad Sci U S A. 2014 Sep 16;111(37):13367-72. doi: 10.1073/pnas.1412081111. Epub 2014 Sep 3.


DNA methylation reprogramming in cancer: does it act by re-configuring the binding landscape of Polycomb repressive complexes?

Reddington JP, Sproul D, Meehan RR.

Bioessays. 2014 Feb;36(2):134-40. doi: 10.1002/bies.201300130. Epub 2013 Nov 26.


Expression of a large LINE-1-driven antisense RNA is linked to epigenetic silencing of the metastasis suppressor gene TFPI-2 in cancer.

Cruickshanks HA, Vafadar-Isfahani N, Dunican DS, Lee A, Sproul D, Lund JN, Meehan RR, Tufarelli C.

Nucleic Acids Res. 2013 Aug;41(14):6857-69. doi: 10.1093/nar/gkt438. Epub 2013 May 23.


Genomic insights into cancer-associated aberrant CpG island hypermethylation.

Sproul D, Meehan RR.

Brief Funct Genomics. 2013 May;12(3):174-90. doi: 10.1093/bfgp/els063. Epub 2013 Jan 21. Review.


Tissue of origin determines cancer-associated CpG island promoter hypermethylation patterns.

Sproul D, Kitchen RR, Nestor CE, Dixon JM, Sims AH, Harrison DJ, Ramsahoye BH, Meehan RR.

Genome Biol. 2012 Oct 3;13(10):R84. doi: 10.1186/gb-2012-13-10-r84.


Targeting of Rac GTPases blocks the spread of intact human breast cancer.

Katz E, Sims AH, Sproul D, Caldwell H, Dixon MJ, Meehan RR, Harrison DJ.

Oncotarget. 2012 Jun;3(6):608-19.


Diversity of matriptase expression level and function in breast cancer.

Welman A, Sproul D, Mullen P, Muir M, Kinnaird AR, Harrison DJ, Faratian D, Brunton VG, Frame MC.

PLoS One. 2012;7(4):e34182. doi: 10.1371/journal.pone.0034182. Epub 2012 Apr 13.


Lactate, a product of glycolytic metabolism, inhibits histone deacetylase activity and promotes changes in gene expression.

Latham T, Mackay L, Sproul D, Karim M, Culley J, Harrison DJ, Hayward L, Langridge-Smith P, Gilbert N, Ramsahoye BH.

Nucleic Acids Res. 2012 Jun;40(11):4794-803. doi: 10.1093/nar/gks066. Epub 2012 Feb 9.


Tissue type is a major modifier of the 5-hydroxymethylcytosine content of human genes.

Nestor CE, Ottaviano R, Reddington J, Sproul D, Reinhardt D, Dunican D, Katz E, Dixon JM, Harrison DJ, Meehan RR.

Genome Res. 2012 Mar;22(3):467-77. doi: 10.1101/gr.126417.111. Epub 2011 Nov 21.


Modelling genetic and clinical heterogeneity in epithelial ovarian cancers.

Lawrenson K, Sproul D, Grun B, Notaridou M, Benjamin E, Jacobs IJ, Dafou D, Sims AH, Gayther SA.

Carcinogenesis. 2011 Oct;32(10):1540-9. doi: 10.1093/carcin/bgr140. Epub 2011 Aug 22.


Transcriptionally repressed genes become aberrantly methylated and distinguish tumors of different lineages in breast cancer.

Sproul D, Nestor C, Culley J, Dickson JH, Dixon JM, Harrison DJ, Meehan RR, Sims AH, Ramsahoye BH.

Proc Natl Acad Sci U S A. 2011 Mar 15;108(11):4364-9. doi: 10.1073/pnas.1013224108. Epub 2011 Feb 28.


Analysis of active and inactive X chromosome architecture reveals the independent organization of 30 nm and large-scale chromatin structures.

Naughton C, Sproul D, Hamilton C, Gilbert N.

Mol Cell. 2010 Nov 12;40(3):397-409. doi: 10.1016/j.molcel.2010.10.013.


Ring1B compacts chromatin structure and represses gene expression independent of histone ubiquitination.

Eskeland R, Leeb M, Grimes GR, Kress C, Boyle S, Sproul D, Gilbert N, Fan Y, Skoultchi AI, Wutz A, Bickmore WA.

Mol Cell. 2010 May 14;38(3):452-64. doi: 10.1016/j.molcel.2010.02.032.


Recruitment to the nuclear periphery can alter expression of genes in human cells.

Finlan LE, Sproul D, Thomson I, Boyle S, Kerr E, Perry P, Ylstra B, Chubb JR, Bickmore WA.

PLoS Genet. 2008 Mar 21;4(3):e1000039. doi: 10.1371/journal.pgen.1000039.


The role of chromatin structure in regulating the expression of clustered genes.

Sproul D, Gilbert N, Bickmore WA.

Nat Rev Genet. 2005 Oct;6(10):775-81. Review.


Adenosine deaminases acting on RNA (ADARs): RNA-editing enzymes.

Keegan LP, Leroy A, Sproul D, O'Connell MA.

Genome Biol. 2004;5(2):209. Epub 2004 Feb 2. Review.


WORLD welcomes new executive director.

Sproul D.

WORLD. 2002 Mar;(131):3. No abstract available.

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