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Results: 1 to 20 of 79

1.

A specific PTPRC/CD45 phosphorylation event governed by stem cell chemokine CXCL12 regulates primitive hematopoietic cell motility.

Williamson AJ, Pierce A, Jaworska E, Zhou C, Aspinall-O'Dea M, Lancashire L, Unwin RD, Abraham SA, Walker MJ, Cadecco S, Spooncer E, Holyoake TL, Whetton AD.

Mol Cell Proteomics. 2013 Nov;12(11):3319-29. doi: 10.1074/mcp.M112.024604. Epub 2013 Sep 1.

PMID:
23997015
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Identification of nuclear protein targets for six leukemogenic tyrosine kinases governed by post-translational regulation.

Pierce A, Williamson A, Jaworska E, Griffiths JR, Taylor S, Walker M, Aspinall-O'Dea M, Spooncer E, Unwin RD, Poolman T, Ray D, Whetton AD.

PLoS One. 2012;7(6):e38928. doi: 10.1371/journal.pone.0038928. Epub 2012 Jun 22. Erratum in: PLoS One. 2013;8(6). doi:10.1371/annotation/df82a4c0-2909-43a0-8a7f-5bd2ce9ca0bd. O'Dea, Mark Aspinall [corrected to Aspinall-O'Dea, Mark].

PMID:
22745689
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

BCR/ABL modulates protein phosphorylation associated with the etoposide-induced DNA damage response.

Griaud F, Williamson AJ, Taylor S, Potier DN, Spooncer E, Pierce A, Whetton AD.

J Proteomics. 2012 Dec 21;77:14-26. doi: 10.1016/j.jprot.2012.06.003. Epub 2012 Jun 15.

PMID:
22705319
[PubMed - indexed for MEDLINE]
4.

Genome-wide analysis of transcriptional reprogramming in mouse models of acute myeloid leukaemia.

Bonadies N, Foster SD, Chan WI, Kvinlaug BT, Spensberger D, Dawson MA, Spooncer E, Whetton AD, Bannister AJ, Huntly BJ, Göttgens B.

PLoS One. 2011 Jan 28;6(1):e16330. doi: 10.1371/journal.pone.0016330.

PMID:
21297973
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

THOC5/FMIP, an mRNA export TREX complex protein, is essential for hematopoietic primitive cell survival in vivo.

Mancini A, Niemann-Seyde SC, Pankow R, El Bounkari O, Klebba-Färber S, Koch A, Jaworska E, Spooncer E, Gruber AD, Whetton AD, Tamura T.

BMC Biol. 2010 Jan 5;8:1. doi: 10.1186/1741-7007-8-1.

PMID:
20051105
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Developmental fate determination and marker discovery in hematopoietic stem cell biology using proteomic fingerprinting.

Spooncer E, Brouard N, Nilsson SK, Williams B, Liu MC, Unwin RD, Blinco D, Jaworska E, Simmons PJ, Whetton AD.

Mol Cell Proteomics. 2008 Mar;7(3):573-81. Epub 2007 Dec 14.

PMID:
18083999
[PubMed - indexed for MEDLINE]
Free Article
7.

Eight-channel iTRAQ enables comparison of the activity of six leukemogenic tyrosine kinases.

Pierce A, Unwin RD, Evans CA, Griffiths S, Carney L, Zhang L, Jaworska E, Lee CF, Blinco D, Okoniewski MJ, Miller CJ, Bitton DA, Spooncer E, Whetton AD.

Mol Cell Proteomics. 2008 May;7(5):853-63. Epub 2007 Oct 21.

PMID:
17951628
[PubMed - indexed for MEDLINE]
Free Article
8.

The rho-kinase inhibitors Y-27632 and fasudil act synergistically with imatinib to inhibit the expansion of ex vivo CD34(+) CML progenitor cells.

Burthem J, Rees-Unwin K, Mottram R, Adams J, Lucas GS, Spooncer E, Whetton AD.

Leukemia. 2007 Aug;21(8):1708-14. Epub 2007 Jun 7.

PMID:
17554385
[PubMed - indexed for MEDLINE]
9.

Differential effect of leukaemogenic tyrosine kinases on cell motility is governed by subcellular localisation.

Pierce A, Lu Y, Hamzah HG, Thompson S, Owen-Lynch PJ, Whetton AD, Spooncer E.

Br J Haematol. 2006 May;133(3):345-52.

PMID:
16643438
[PubMed - indexed for MEDLINE]
10.

Quantitative proteomics reveals posttranslational control as a regulatory factor in primary hematopoietic stem cells.

Unwin RD, Smith DL, Blinco D, Wilson CL, Miller CJ, Evans CA, Jaworska E, Baldwin SA, Barnes K, Pierce A, Spooncer E, Whetton AD.

Blood. 2006 Jun 15;107(12):4687-94. Epub 2006 Feb 28.

PMID:
16507774
[PubMed - indexed for MEDLINE]
Free Article
11.

Chronic myeloid leukemia CD34+ cells have elevated levels of phosphatidylinositol 3,4,5 trisphosphate (PtdIns(3,4,5)P3) and lack a PtdIns(3,4,5)P3 response to cytokines and chemotactic factors; effects reversed by imatinib.

Hamzah HG, Pierce A, Stewart WA, Peter Downes C, Gray A, Irvine A, Spooncer E, Whetton AD.

Leukemia. 2005 Oct;19(10):1851-3. No abstract available.

PMID:
16107888
[PubMed - indexed for MEDLINE]
12.

Comparative proteomics of primitive hematopoietic cell populations reveals differences in expression of proteins regulating motility.

Evans CA, Tonge R, Blinco D, Pierce A, Shaw J, Lu Y, Hamzah HG, Gray A, Downes CP, Gaskell SJ, Spooncer E, Whetton AD.

Blood. 2004 May 15;103(10):3751-9. Epub 2004 Feb 5.

PMID:
14764529
[PubMed - indexed for MEDLINE]
Free Article
13.

Generation of a conditionally immortalized myeloid progenitor cell line requiring the presence of both interleukin-3 and stem cell factor to survive and proliferate.

Lee C, Evans CA, Spooncer E, Pierce A, Mottram R, Whetton AD.

Br J Haematol. 2003 Sep;122(6):985-95.

PMID:
12956770
[PubMed - indexed for MEDLINE]
14.

Lysophospholipids synergistically promote primitive hematopoietic cell chemotaxis via a mechanism involving Vav 1.

Whetton AD, Lu Y, Pierce A, Carney L, Spooncer E.

Blood. 2003 Oct 15;102(8):2798-802. Epub 2003 Jun 26.

PMID:
12829605
[PubMed - indexed for MEDLINE]
Free Article
15.

BCR-ABL alters the proliferation and differentiation response of multipotent hematopoietic cells to stem cell factor.

Pierce A, Spooncer E, Ainsworth S, Whetton AD.

Oncogene. 2002 May 2;21(19):3068-75.

PMID:
12082538
[PubMed - indexed for MEDLINE]
Free Article
16.

The specific enhancement of interferon alpha induced growth inhibition by BCR/ABL only occurs in multipotent cells.

Pierce A, Smith DL, Jakobsen LV, Whetton AD, Spooncer E.

Hematol J. 2001;2(4):257-64.

PMID:
11920258
[PubMed - indexed for MEDLINE]
17.

Bcr-Abl protein tyrosine kinase activity induces a loss of p53 protein that mediates a delay in myeloid differentiation.

Pierce A, Spooncer E, Wooley S, Dive C, Francis JM, Miyan J, Owen-Lynch PJ, Dexter TM, Whetton AD.

Oncogene. 2000 Nov 16;19(48):5487-97.

PMID:
11114726
[PubMed - indexed for MEDLINE]
Free Article
18.

Insertional mutagenesis as a route to identifying genes involved in self renewal of haemopoietic stem cells.

Just U, Boettiger D, Kan O, Dexter TM, Spooncer E.

Curr Top Microbiol Immunol. 2000;251:27-34.

PMID:
11036755
[PubMed - indexed for MEDLINE]
19.

Transforming growth factor-beta 1 induces apoptosis independently of p53 and selectively reduces expression of Bcl-2 in multipotent hematopoietic cells.

Francis JM, Heyworth CM, Spooncer E, Pierce A, Dexter TM, Whetton AD.

J Biol Chem. 2000 Dec 15;275(50):39137-45.

PMID:
10993901
[PubMed - indexed for MEDLINE]
Free Article
20.

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