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A Bronchial Genomic Classifier for the Diagnostic Evaluation of Lung Cancer.

Silvestri GA, Vachani A, Whitney D, Elashoff M, Porta Smith K, Ferguson JS, Parsons E, Mitra N, Brody J, Lenburg ME, Spira A; AEGIS Study Team.

N Engl J Med. 2015 May 17. [Epub ahead of print]


The Host Response to the Lung Microbiome in Chronic Obstructive Pulmonary Disease.

Sze MA, Dimitriu PA, Suzuki M, McDonough JE, Campbell JD, Brothers JF, Erb-Downward JR, Huffnagle GB, Hayashi S, Elliott WM, Cooper J, Sin DD, Lenburg ME, Spira A, Mohn WW, Hogg JC.

Am J Respir Crit Care Med. 2015 May 6. [Epub ahead of print]


Derivation of a bronchial genomic classifier for lung cancer in a prospective study of patients undergoing diagnostic bronchoscopy.

Whitney DH, Elashoff MR, Porta-Smith K, Gower AC, Vachani A, Ferguson JS, Silvestri GA, Brody JS, Lenburg ME, Spira A.

BMC Med Genomics. 2015 May 6;8(1):18. doi: 10.1186/s12920-015-0091-3.


Defining the nasal transcriptome in granulomatosis with polyangiitis.

Grayson PC, Steiling K, Platt M, Berman JS, Zhang X, Xiao J, Alekseyev YO, Liu G, Monach PA, Kaplan MJ, Spira A, Merkel PA.

Arthritis Rheumatol. 2015 May 4. doi: 10.1002/art.39185. [Epub ahead of print]


Emergence of a Stage-Dependent Human Liver Disease Signature with Directed Differentiation of Alpha-1 Antitrypsin-Deficient iPS Cells.

Wilson AA, Ying L, Liesa M, Segeritz CP, Mills JA, Shen SS, Jean J, Lonza GC, Liberti DC, Lang AH, Nazaire J, Gower AC, Müeller FJ, Mehta P, Ordóñez A, Lomas DA, Vallier L, Murphy GJ, Mostoslavsky G, Spira A, Shirihai OS, Ramirez MI, Gadue P, Kotton DN.

Stem Cell Reports. 2015 May 12;4(5):873-85. doi: 10.1016/j.stemcr.2015.02.021. Epub 2015 Apr 2.


SubmiRine: assessing variants in microRNA targets using clinical genomic data sets.

Maxwell EK, Campbell JD, Spira A, Baxevanis AD.

Nucleic Acids Res. 2015 Apr 30;43(8):3886-98. doi: 10.1093/nar/gkv256. Epub 2015 Mar 26.


Sleep interacts with aβ to modulate intrinsic neuronal excitability.

Tabuchi M, Lone SR, Liu S, Liu Q, Zhang J, Spira AP, Wu MN.

Curr Biol. 2015 Mar 16;25(6):702-12. doi: 10.1016/j.cub.2015.01.016. Epub 2015 Mar 5.


Comment on: Evolution of multiple sclerosis in France since the beginning of hepatitis B vaccination.

Spira A, Bégué P, Aurengo A.

Immunol Res. 2015 May;62(1):1-2. doi: 10.1007/s12026-015-8627-3. No abstract available.


Markers of Impaired Decision Making in Nursing Home Residents: Assessment by Nursing Home Staff in a Population-Based Study.

Fain KM, Rosenberg PB, Pirard S, Bogunovic O, Spira AP.

J Am Med Dir Assoc. 2015 Feb 14. pii: S1525-8610(15)00081-X. doi: 10.1016/j.jamda.2015.01.080. [Epub ahead of print]


Being mindful of later-life sleep quality and its potential role in prevention.

Spira AP.

JAMA Intern Med. 2015 Apr 1;175(4):502-3. doi: 10.1001/jamainternmed.2014.8093. No abstract available.


Variables associated with effects on morbidity in older adults following disasters.

Jenkins JL, Levy M, Rutkow L, Spira A.

PLoS Curr. 2014 Dec 5;6. pii: ecurrents.dis.0fe970aa16d51cde6a962b7a732e494a. doi: 10.1371/currents.dis.0fe970aa16d51cde6a962b7a732e494a.


Translating the transcriptome into tools for the early detection and prevention of lung cancer.

Gesthalter YB, Vick J, Steiling K, Spira A.

Thorax. 2015 May;70(5):476-481. doi: 10.1136/thoraxjnl-2014-206605. Epub 2015 Jan 27. Review.


Objectively Measured Sleep and β-amyloid Burden in Older Adults: A Pilot Study.

Spira AP, Yager C, Brandt J, Smith GS, Zhou Y, Mathur A, Kumar A, Brašić JR, Wong DF, Wu MN.

SAGE Open Med. 2014 Aug 12;2. doi: 10.1177/2050312114546520.


Asthma-COPD Overlap. Clinical Relevance of Genomic Signatures of Type 2 Inflammation in Chronic Obstructive Pulmonary Disease.

Christenson SA, Steiling K, van den Berge M, Hijazi K, Hiemstra PS, Postma DS, Lenburg ME, Spira A, Woodruff PG.

Am J Respir Crit Care Med. 2015 Apr 1;191(7):758-66. doi: 10.1164/rccm.201408-1458OC.


A randomized, phase 2 trial of docetaxel with or without PX-866, an irreversible oral phosphatidylinositol 3-kinase inhibitor, in patients with relapsed or metastatic head and neck squamous cell cancer.

Jimeno A, Bauman JE, Weissman C, Adkins D, Schnadig I, Beauregard P, Bowles DW, Spira A, Levy B, Seetharamu N, Hausman D, Walker L, Rudin CM, Shirai K.

Oral Oncol. 2015 Apr;51(4):383-8. doi: 10.1016/j.oraloncology.2014.12.013. Epub 2015 Jan 13.


Integrative analysis of DNA methylation and gene expression data identifies EPAS1 as a key regulator of COPD.

Yoo S, Takikawa S, Geraghty P, Argmann C, Campbell J, Lin L, Huang T, Tu Z, Feronjy R, Spira A, Schadt EE, Powell CA, Zhu J.

PLoS Genet. 2015 Jan 8;11(1):e1004898. doi: 10.1371/journal.pgen.1004898. eCollection 2015 Jan.


A randomized, phase II trial of cetuximab with or without PX-866, an irreversible oral phosphatidylinositol 3-kinase inhibitor, in patients with relapsed or metastatic head and neck squamous cell cancer.

Jimeno A, Shirai K, Choi M, Laskin J, Kochenderfer M, Spira A, Cline-Burkhardt V, Winquist E, Hausman D, Walker L, Cohen RB.

Ann Oncol. 2015 Mar;26(3):556-61. doi: 10.1093/annonc/mdu574. Epub 2014 Dec 18.


Assessment of microRNA differential expression and detection in multiplexed small RNA sequencing data.

Campbell JD, Liu G, Luo L, Xiao J, Gerrein J, Juan-Guardela B, Tedrow J, Alekseyev YO, Yang IV, Correll M, Geraci M, Quackenbush J, Sciurba F, Schwartz DA, Kaminski N, Johnson WE, Monti S, Spira A, Beane J, Lenburg ME.

RNA. 2015 Feb;21(2):164-71. doi: 10.1261/rna.046060.114. Epub 2014 Dec 17.


Substance-use coping and self-rated health among US middle-aged and older adults.

Mauro PM, Canham SL, Martins SS, Spira AP.

Addict Behav. 2015 Mar;42:96-100. doi: 10.1016/j.addbeh.2014.10.031. Epub 2014 Nov 5.


Sleep-disordered breathing and functional decline in older women.

Spira AP, Stone KL, Rebok GW, Punjabi NM, Redline S, Ancoli-Israel S, Yaffe K.

J Am Geriatr Soc. 2014 Nov;62(11):2040-6. doi: 10.1111/jgs.13108. Epub 2014 Nov 6.

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