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Species specificity of ADAM10 and ADAM17 proteins in interleukin-6 (IL-6) trans-signaling and novel role of ADAM10 in inducible IL-6 receptor shedding.
Garbers C, Jänner N, Chalaris A, Moss ML, Floss DM, Meyer D, Koch-Nolte F, Rose-John S, Scheller J. Garbers C, et al. J Biol Chem. 2011 Apr 29;286(17):14804-11. doi: 10.1074/jbc.M111.229393. Epub 2011 Mar 15. J Biol Chem. 2011. PMID: 21454673 Free PMC article.
ADAM17 is the main sheddase of interleukin-6 receptor (IL-6R) to induce IL-6 trans-signaling. ...Finally, we identified physiological purinergic P2X7 receptor stimulation as a novel inducer of murine and human IL-6R shedding solely mediated by …
ADAM17 is the main sheddase of interleukin-6 receptor (IL-6R) to induce IL-6 trans-signaling. ...Finally, …
Regulation of adipose tissue inflammation by interleukin 6.
Han MS, White A, Perry RJ, Camporez JP, Hidalgo J, Shulman GI, Davis RJ. Han MS, et al. Proc Natl Acad Sci U S A. 2020 Feb 11;117(6):2751-2760. doi: 10.1073/pnas.1920004117. Epub 2020 Jan 24. Proc Natl Acad Sci U S A. 2020. PMID: 31980524 Free PMC article.
Obesity is associated with a chronic state of low-grade inflammation and progressive tissue infiltration by immune cells and increased expression of inflammatory cytokines. It is established that interleukin 6 (IL6) regulates multiple aspects of metabolism, includin …
Obesity is associated with a chronic state of low-grade inflammation and progressive tissue infiltration by immune cells and increased expre …