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Efficacy of Souroubea-Platanus Dietary Supplement Containing Triterpenes in Beagle Dogs Using a Thunderstorm Noise-Induced Model of Fear and Anxiety.
Masic A, Landsberg G, Milgram B, Merali Z, Durst T, Sanchez Vindas P, Garcia M, Baker J, Liu R, Arnason J. Masic A, et al. Molecules. 2021 Apr 3;26(7):2049. doi: 10.3390/molecules26072049. Molecules. 2021. PMID: 33916654 Free PMC article.
A novel botanical dietary supplement, formulated as a chewable tablet containing a defined mixture of Souroubea spp. vine and Platanus spp. Bark, was tested as a canine anxiolytic for thunderstorm noise-induced stress (noise aversion). ...
A novel botanical dietary supplement, formulated as a chewable tablet containing a defined mixture of Souroubea spp. vine and Platanu …
Souroubea sympetala (Marcgraviaceae): a medicinal plant that exerts anxiolysis through interaction with the GABAA benzodiazepine receptor.
Mullally M, Cayer C, Kramp K, Otárola Rojas M, Sanchez Vindas P, Garcia M, Poveda Alvarez L, Durst T, Merali Z, Trudeau VL, Arnason JT. Mullally M, et al. Can J Physiol Pharmacol. 2014 Sep;92(9):758-64. doi: 10.1139/cjpp-2014-0213. Epub 2014 Jul 28. Can J Physiol Pharmacol. 2014. PMID: 25140794
The mode of action of the anxiolytic medicinal plant Souroubea sympetala was investigated to test the hypothesis that extracts and the active principle act at the pharmacologically important GABAA-benzodiazepine (GABAA-BZD) receptor. ...
The mode of action of the anxiolytic medicinal plant Souroubea sympetala was investigated to test the hypothesis that extracts and th …
Ethnopharmacology of Souroubea sympetala and Souroubea gilgii (Marcgraviaceae) and identification of betulinic acid as an anxiolytic principle.
Puniani E, Cayer C, Kent P, Mullally M, Sánchez-Vindas P, Poveda Álvarez L, Cal V, Merali Z, Arnason JT, Durst T. Puniani E, et al. Phytochemistry. 2015 May;113:73-8. doi: 10.1016/j.phytochem.2014.02.017. Epub 2014 Mar 15. Phytochemistry. 2015. PMID: 24641939
The neotropical lianas Souroubea gilgii and Souroubea sympetala (Marcgraviaceae) were chosen for study as part of a phytochemical discovery strategy focusing on rare plant families in Central America. In participatory research, Q'eqchi' healers in Belize reported th …
The neotropical lianas Souroubea gilgii and Souroubea sympetala (Marcgraviaceae) were chosen for study as part of a phytochemi …
New Botanical Anxiolytics for Use in Companion Animals and Humans.
Liu R, Ahmed F, Cayer C, Mullally M, Carballo AF, Rojas MO, Garcia M, Baker J, Masic A, Sanchez PE, Poveda L, Merali Z, Durst T, Arnason JT. Liu R, et al. AAPS J. 2017 Nov;19(6):1626-1631. doi: 10.1208/s12248-017-0144-y. Epub 2017 Sep 11. AAPS J. 2017. PMID: 28895076 Review.
As part of our ongoing research into botanical therapies for anxiety disorders, the neotropical vine Souroubea sympetala was chosen for study as a phytochemical discovery strategy focusing on rare Central American plant families. ...Pharmacological studies showed that the …
As part of our ongoing research into botanical therapies for anxiety disorders, the neotropical vine Souroubea sympetala was chosen f …
Effect of an anxiolytic botanical containing Souroubea sympetala and Platanus occidentalis on in-vitro diazepam human cytochrome P450-mediated metabolism.
Liu R, Dobson CC, Foster BC, Durst T, Sanchez P, Arnason JT, Harris CS. Liu R, et al. J Pharm Pharmacol. 2019 Mar;71(3):429-437. doi: 10.1111/jphp.13045. Epub 2018 Nov 22. J Pharm Pharmacol. 2019. PMID: 30467864
OBJECTIVES: A novel anxiolytic natural health product (NHP) containing Souroubea sympetala and Platanus occidentalis is available for the companion animal market and is currently being developed for clinical evaluation. Addressing the risk of potential NHP-drug interaction …
OBJECTIVES: A novel anxiolytic natural health product (NHP) containing Souroubea sympetala and Platanus occidentalis is available for …
Extract and Active Principal of the Neotropical Vine Souroubea sympetala Gilg. Block Fear Memory Reconsolidation.
Murkar A, Cayer C, James J, Durst T, Arnason JT, Sanchez-Vindas PE, Otarola Rojas M, Merali Z. Murkar A, et al. Front Pharmacol. 2019 Dec 20;10:1496. doi: 10.3389/fphar.2019.01496. eCollection 2019. Front Pharmacol. 2019. PMID: 31956309 Free PMC article.
Background: Souroubea sympetala Gilg. is a neotropical vine native to Central America, investigated as part of a targeted study of the plant family Marcgraviaceae. ...
Background: Souroubea sympetala Gilg. is a neotropical vine native to Central America, investigated as part of a targeted study of th …
Anxiolytic activity of a supercritical carbon dioxide extract of Souroubea sympetala (Marcgraviaceae).
Mullally M, Kramp K, Cayer C, Saleem A, Ahmed F, McRae C, Baker J, Goulah A, Otorola M, Sanchez P, Garcia M, Poveda L, Merali Z, Durst T, Trudeau VL, Arnason JT. Mullally M, et al. Phytother Res. 2011 Feb;25(2):264-70. doi: 10.1002/ptr.3246. Phytother Res. 2011. PMID: 20648677
The purpose of this work was to develop an extraction technique to yield a betulinic acid-(BA) enriched extract of the traditional anti-anxiety plant Souroubea sympetala Gilg (Marcgraviaceae). Five extraction techniques were compared: supercritical carbon dioxide extractio …
The purpose of this work was to develop an extraction technique to yield a betulinic acid-(BA) enriched extract of the traditional anti-anxi …
Safety evaluation of a new anxiolytic product containing botanicals Souroubea spp. and Platanus spp. in dogs.
Masic A, Liu R, Simkus K, Wilson J, Baker J, Sanchez P, Saleem A, Harris CC, Durst T, Arnason JT. Masic A, et al. Can J Vet Res. 2018 Jan;82(1):3-11. Can J Vet Res. 2018. PMID: 29382964 Free PMC article. Clinical Trial.
Its intended use is for the treatment and prevention of anxiety and noise aversion in dogs. It contains a defined mixture of Souroubea spp. vine and Platanus spp. bark, delivering the active principle, betulinic acid, at a recommended dose of 1 mg/kg body weight (BW). ...
Its intended use is for the treatment and prevention of anxiety and noise aversion in dogs. It contains a defined mixture of Souroubea …
Palynological variation in balsaminoid ericales. I. Marcgraviaceae.
Lens F, Dressler S, Vinckier S, Janssens S, Dessein S, van Evelghem L, Smets E. Lens F, et al. Ann Bot. 2005 Nov;96(6):1047-60. doi: 10.1093/aob/mci256. Epub 2005 Sep 12. Ann Bot. 2005. PMID: 16157628 Free PMC article.
Sarcopera can be defined by the presence of an oblate spheroidal to even suboblate shape, while Ruyschia and Souroubea typically show prolate spheroidal to subprolate pollen grains. ...
Sarcopera can be defined by the presence of an oblate spheroidal to even suboblate shape, while Ruyschia and Souroubea typically show …