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Results: 1 to 20 of 141


Fractional killing arises from cell-to-cell variability in overcoming a caspase activity threshold.

Roux J, Hafner M, Bandara S, Sims JJ, Hudson H, Chai D, Sorger PK.

Mol Syst Biol. 2015 May 7;11(5):803. doi: 10.15252/msb.20145584.


Surviving apoptosis: life-death signaling in single cells.

Flusberg DA, Sorger PK.

Trends Cell Biol. 2015 Apr 25. pii: S0962-8924(15)00055-0. doi: 10.1016/j.tcb.2015.03.003. [Epub ahead of print] Review.


Systematic analysis of BRAFV600E melanomas reveals a role for JNK/c-Jun pathway in adaptive resistance to drug-induced apoptosis.

Fallahi-Sichani M, Moerke NJ, Niepel M, Zhang T, Gray NS, Sorger PK.

Mol Syst Biol. 2015 Mar 26;11(3):797. doi: 10.15252/msb.20145877.


A noncanonical Frizzled2 pathway regulates epithelial-mesenchymal transition and metastasis.

Gujral TS, Chan M, Peshkin L, Sorger PK, Kirschner MW, MacBeath G.

Cell. 2014 Nov 6;159(4):844-56. doi: 10.1016/j.cell.2014.10.032.


A multiscale statistical mechanical framework integrates biophysical and genomic data to assemble cancer networks.

AlQuraishi M, Koytiger G, Jenney A, MacBeath G, Sorger PK.

Nat Genet. 2014 Dec;46(12):1363-71. doi: 10.1038/ng.3138. Epub 2014 Nov 2.


Chromosome instability induced by Mps1 and p53 mutation generates aggressive lymphomas exhibiting aneuploidy-induced stress.

Foijer F, Xie SZ, Simon JE, Bakker PL, Conte N, Davis SH, Kregel E, Jonkers J, Bradley A, Sorger PK.

Proc Natl Acad Sci U S A. 2014 Sep 16;111(37):13427-32. doi: 10.1073/pnas.1400892111. Epub 2014 Sep 2.


LINCS Canvas Browser: interactive web app to query, browse and interrogate LINCS L1000 gene expression signatures.

Duan Q, Flynn C, Niepel M, Hafner M, Muhlich JL, Fernandez NF, Rouillard AD, Tan CM, Chen EY, Golub TR, Sorger PK, Subramanian A, Ma'ayan A.

Nucleic Acids Res. 2014 Jul;42(Web Server issue):W449-60. doi: 10.1093/nar/gku476. Epub 2014 Jun 6.


Analysis of growth factor signaling in genetically diverse breast cancer lines.

Niepel M, Hafner M, Pace EA, Chung M, Chai DH, Zhou L, Muhlich JL, Schoeberl B, Sorger PK.

BMC Biol. 2014 Mar 21;12:20. doi: 10.1186/1741-7007-12-20.


Intra- and interdimeric caspase-8 self-cleavage controls strength and timing of CD95-induced apoptosis.

Kallenberger SM, Beaudouin J, Claus J, Fischer C, Sorger PK, Legewie S, Eils R.

Sci Signal. 2014 Mar 11;7(316):ra23. doi: 10.1126/scisignal.2004738.


Decision-tree based model analysis for efficient identification of parameter relations leading to different signaling states.

Koch Y, Wolf T, Sorger PK, Eils R, Brors B.

PLoS One. 2013 Dec 18;8(12):e82593. doi: 10.1371/journal.pone.0082593. eCollection 2013.


Profiles of Basal and stimulated receptor signaling networks predict drug response in breast cancer lines.

Niepel M, Hafner M, Pace EA, Chung M, Chai DH, Zhou L, Schoeberl B, Sorger PK.

Sci Signal. 2013 Sep 24;6(294):ra84. doi: 10.1126/scisignal.2004379.


Metrics other than potency reveal systematic variation in responses to cancer drugs.

Fallahi-Sichani M, Honarnejad S, Heiser LM, Gray JW, Sorger PK.

Nat Chem Biol. 2013 Nov;9(11):708-14. doi: 10.1038/nchembio.1337. Epub 2013 Sep 8.


S. cerevisiae chromosomes biorient via gradual resolution of syntely between S phase and anaphase.

Marco E, Dorn JF, Hsu PH, Jaqaman K, Sorger PK, Danuser G.

Cell. 2013 Aug 29;154(5):1127-39. doi: 10.1016/j.cell.2013.08.008.


Discovering causal pathways linking genomic events to transcriptional states using Tied Diffusion Through Interacting Events (TieDIE).

Paull EO, Carlin DE, Niepel M, Sorger PK, Haussler D, Stuart JM.

Bioinformatics. 2013 Nov 1;29(21):2757-64. doi: 10.1093/bioinformatics/btt471. Epub 2013 Aug 27.


Modulating cell-to-cell variability and sensitivity to death ligands by co-drugging.

Flusberg DA, Sorger PK.

Phys Biol. 2013 Jun;10(3):035002. doi: 10.1088/1478-3975/10/3/035002. Epub 2013 Jun 4.


Cells surviving fractional killing by TRAIL exhibit transient but sustainable resistance and inflammatory phenotypes.

Flusberg DA, Roux J, Spencer SL, Sorger PK.

Mol Biol Cell. 2013 Jul;24(14):2186-200. doi: 10.1091/mbc.E12-10-0737. Epub 2013 May 22.


Mass spectrometry based method to increase throughput for kinome analyses using ATP probes.

McAllister FE, Niepel M, Haas W, Huttlin E, Sorger PK, Gygi SP.

Anal Chem. 2013 May 7;85(9):4666-74. doi: 10.1021/ac303478g. Epub 2013 Apr 22.


Programming biological models in Python using PySB.

Lopez CF, Muhlich JL, Bachman JA, Sorger PK.

Mol Syst Biol. 2013;9:646. doi: 10.1038/msb.2013.1.


Properties of cell death models calibrated and compared using Bayesian approaches.

Eydgahi H, Chen WW, Muhlich JL, Vitkup D, Tsitsiklis JN, Sorger PK.

Mol Syst Biol. 2013;9:644. doi: 10.1038/msb.2012.69.


Spindle checkpoint deficiency is tolerated by murine epidermal cells but not hair follicle stem cells.

Foijer F, DiTommaso T, Donati G, Hautaviita K, Xie SZ, Heath E, Smyth I, Watt FM, Sorger PK, Bradley A.

Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):2928-33. doi: 10.1073/pnas.1217388110. Epub 2013 Feb 4.

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