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Ann Neurol. 2002 Aug;52(2):247-50.

Selective loss of cholinergic sudomotor fibers causes anhidrosis in Ross syndrome.

Author information

  • 1Department of Neurology, University of Würzburg, Würzburg, Germany. sommer@mail.uni-wuerzburg.de

Abstract

Ross syndrome consists of segmental hyperhidrosis with widespread anhidrosis, Adie syndrome, and areflexia. The cause of this disorder is unknown. Selective degeneration of cholinergic fibers or of neural crest-derived structures has been suggested. We present clinical and skin biopsy data of 4 patients, providing evidence of reduced cholinergic sweat gland innervation in hypohidrotic skin by morphometric analysis. These findings indicate a selective degenerative process of the cholinergic sudomotor neurons.

PMID:
12210801
[PubMed - indexed for MEDLINE]
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