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Results: 1 to 20 of 27

1.

Endothelial-like progenitor cells engineered to produce prostacyclin rescue monocrotaline-induced pulmonary arterial hypertension and provide right ventricle benefits.

Zhou L, Chen Z, Vanderslice P, So SP, Ruan KH, Willerson JT, Dixon RA.

Circulation. 2013 Aug 27;128(9):982-94. doi: 10.1161/CIRCULATIONAHA.113.003139. Epub 2013 Jul 10.

PMID:
23841984
[PubMed - indexed for MEDLINE]
2.

Resistant to thrombosis, induced stroke and heart arrest by incorporation of a single gene of PGI2-synthesizing COX-1-PGIS in vivo: Implication against human heart disease.

Ruan KH, Mohite AJ, So SP.

Int J Cardiol. 2013 Oct 3;168(3):2960-1. doi: 10.1016/j.ijcard.2013.03.114. Epub 2013 Apr 18. No abstract available.

PMID:
23602873
[PubMed - in process]
3.

Screening and identification of dietary oils and unsaturated fatty acids in inhibiting inflammatory prostaglandin E2 signaling in fat stromal cells.

Ruan D, So SP.

BMC Complement Altern Med. 2012 Aug 31;12:143. doi: 10.1186/1472-6882-12-143.

PMID:
22938033
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Engineered endothelial progenitor cells that overexpress prostacyclin protect vascular cells.

Liu Q, Xi Y, Terry T, So SP, Mohite A, Zhang J, Wu G, Liu X, Cheng J, Ruan KH, Willerson JT, Dixon RA.

J Cell Physiol. 2012 Jul;227(7):2907-16. doi: 10.1002/jcp.23035.

PMID:
21938725
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Establishing novel prostacyclin-synthesizing cells with therapeutic potential against heart diseases.

Ruan KH, Mohite A, So SP, Ruan CH.

Int J Cardiol. 2013 Feb 20;163(2):163-9. doi: 10.1016/j.ijcard.2011.06.007. Epub 2011 Jun 30.

PMID:
21722977
[PubMed - indexed for MEDLINE]
6.

Novel mechanism of the vascular protector prostacyclin: regulating microRNA expression.

Mohite A, Chillar A, So SP, Cervantes V, Ruan KH.

Biochemistry. 2011 Mar 15;50(10):1691-9. doi: 10.1021/bi101654w. Epub 2011 Feb 20.

PMID:
21250659
[PubMed - indexed for MEDLINE]
7.

Inducible COX-2 dominates over COX-1 in prostacyclin biosynthesis: mechanisms of COX-2 inhibitor risk to heart disease.

Ruan CH, So SP, Ruan KH.

Life Sci. 2011 Jan 3;88(1-2):24-30. doi: 10.1016/j.lfs.2010.10.017. Epub 2010 Oct 28.

PMID:
21035466
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

A profile of NSAID-targeted arachidonic acid metabolisms in human embryonic stem cells (hESCs): implication of the negative effects of NSAIDs on heart tissue regeneration.

Chillar A, So SP, Ruan CH, Shelat H, Geng YJ, Ruan KH.

Int J Cardiol. 2011 Aug 4;150(3):253-9. doi: 10.1016/j.ijcard.2010.04.015. Epub 2010 May 7.

PMID:
20451268
[PubMed - indexed for MEDLINE]
9.

Engineering of a novel hybrid enzyme: an anti-inflammatory drug target with triple catalytic activities directly converting arachidonic acid into the inflammatory prostaglandin E2.

Ruan KH, Cervantes V, So SP.

Protein Eng Des Sel. 2009 Dec;22(12):733-40. doi: 10.1093/protein/gzp058. Epub 2009 Oct 22.

PMID:
19850676
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

An active triple-catalytic hybrid enzyme engineered by linking cyclo-oxygenase isoform-1 to prostacyclin synthase that can constantly biosynthesize prostacyclin, the vascular protector.

Ruan KH, So SP, Cervantes V, Wu H, Wijaya C, Jentzen RR.

FEBS J. 2008 Dec;275(23):5820-9. doi: 10.1111/j.1742-4658.2008.06703.x.

PMID:
19021758
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Large-scale expression, purification, and characterization of an engineered prostacyclin-synthesizing enzyme with therapeutic potential.

Ruan KH, So SP, Wu H, Cervantes V.

Arch Biochem Biophys. 2008 Dec 1;480(1):41-50. doi: 10.1016/j.abb.2008.09.010. Epub 2008 Sep 22.

PMID:
18835243
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Involvement of non-conserved residues important for PGE2 binding to the constrained EP3 eLP2 using NMR and site-directed mutagenesis.

Chillar A, Wu J, So SP, Ruan KH.

FEBS Lett. 2008 Aug 20;582(19):2863-8. doi: 10.1016/j.febslet.2008.07.018. Epub 2008 Jul 22.

PMID:
18652829
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

A profile of the residues in the second extracellular loop that are critical for ligand recognition of human prostacyclin receptor.

Ni F, So SP, Cervantes V, Ruan KH.

FEBS J. 2008 Jan;275(1):128-37. Epub 2007 Nov 27.

PMID:
18042246
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Efficacy of multidisciplinary approach in treatment of constipation: a pilot study.

Lau PY, Fung B, Meng WC, Leung R, Yip AW, So SP, Lee QS, Chan D.

Hong Kong Med J. 2006 Dec;12(6):415-8.

PMID:
17148792
[PubMed - indexed for MEDLINE]
Free Article
15.

Engineering of a protein with cyclooxygenase and prostacyclin synthase activities that converts arachidonic acid to prostacyclin.

Ruan KH, Deng H, So SP.

Biochemistry. 2006 Nov 28;45(47):14003-11.

PMID:
17115695
[PubMed - indexed for MEDLINE]
16.

The N-terminal membrane anchor domain of the membrane-bound prostacyclin synthase involved in the substrate presentation of the coupling reaction with cyclooxygenase.

Ruan KH, Deng H, Wu J, So SP.

Arch Biochem Biophys. 2005 Mar 15;435(2):372-81.

PMID:
15708381
[PubMed - indexed for MEDLINE]
17.

NMR structure of the thromboxane A2 receptor ligand recognition pocket.

Ruan KH, Wu J, So SP, Jenkins LA, Ruan CH.

Eur J Biochem. 2004 Jul;271(14):3006-16.

PMID:
15233797
[PubMed - indexed for MEDLINE]
Free Article
18.

Structural and functional characterization of the first intracellular loop of human thromboxane A2 receptor.

Geng L, Wu J, So SP, Huang G, Ruan KH.

Arch Biochem Biophys. 2004 Mar 15;423(2):253-65.

PMID:
15001390
[PubMed - indexed for MEDLINE]
19.

Evidence of the residues involved in ligand recognition in the second extracellular loop of the prostacyclin receptor characterized by high resolution 2D NMR techniques.

Ruan KH, Wu J, So SP, Jenkins LA.

Arch Biochem Biophys. 2003 Oct 1;418(1):25-33.

PMID:
13679079
[PubMed - indexed for MEDLINE]
20.

Solution structure of the third extracellular loop of human thromboxane A2 receptor.

Wu J, So SP, Ruan KH.

Arch Biochem Biophys. 2003 Jun 15;414(2):287-93.

PMID:
12781781
[PubMed - indexed for MEDLINE]

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