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Items: 1 to 20 of 63


Dual A1/A2B Receptor Blockade Improves Cardiac and Renal Outcomes in a Rat Model of Heart Failure with Preserved Ejection Fraction.

Tofovic SP, Salah EM, Smits GJ, Whalley ET, Ticho B, Deykin A, Jackson EK.

J Pharmacol Exp Ther. 2016 Feb;356(2):333-40. doi: 10.1124/jpet.115.228841. Epub 2015 Nov 19.


Comparative physiological and transcriptional analysis of weak organic acid stress in Bacillus subtilis.

Ter Beek A, Wijman JG, Zakrzewska A, Orij R, Smits GJ, Brul S.

Food Microbiol. 2015 Feb;45(Pt A):71-82. doi: 10.1016/ Epub 2014 Feb 26.


Yeast adaptation to weak acids prevents futile energy expenditure.

Ullah A, Chandrasekaran G, Brul S, Smits GJ.

Front Microbiol. 2013 Jun 11;4:142. doi: 10.3389/fmicb.2013.00142. eCollection 2013.


Metabolic phenotypes of Saccharomyces cerevisiae mutants with altered trehalose 6-phosphate dynamics.

Walther T, Mtimet N, Alkim C, Vax A, Loret MO, Ullah A, Gancedo C, Smits GJ, François JM.

Biochem J. 2013 Sep 1;454(2):227-37. doi: 10.1042/BJ20130587.


Intracellular pH homeostasis in Candida glabrata in infection-associated conditions.

Ullah A, Lopes MI, Brul S, Smits GJ.

Microbiology. 2013 Apr;159(Pt 4):803-13. doi: 10.1099/mic.0.063610-0. Epub 2013 Feb 1.


Genome-wide analysis of intracellular pH reveals quantitative control of cell division rate by pH(c) in Saccharomyces cerevisiae.

Orij R, Urbanus ML, Vizeacoumar FJ, Giaever G, Boone C, Nislow C, Brul S, Smits GJ.

Genome Biol. 2012 Sep 10;13(9):R80. doi: 10.1186/gb-2012-13-9-r80.


Quantitative analysis of the modes of growth inhibition by weak organic acids in Saccharomyces cerevisiae.

Ullah A, Orij R, Brul S, Smits GJ.

Appl Environ Microbiol. 2012 Dec;78(23):8377-87. doi: 10.1128/AEM.02126-12. Epub 2012 Sep 21.


Topology of transcriptional regulatory networks: testing and improving.

Hasdemir D, Smits GJ, Westerhuis JA, Smilde AK.

PLoS One. 2012;7(7):e40082. doi: 10.1371/journal.pone.0040082. Epub 2012 Jul 23.


Isoenzyme expression changes in response to high temperature determine the metabolic regulation of increased glycolytic flux in yeast.

Postmus J, Aardema R, de Koning LJ, de Koster CG, Brul S, Smits GJ.

FEMS Yeast Res. 2012 Aug;12(5):571-81. doi: 10.1111/j.1567-1364.2012.00807.x. Epub 2012 Apr 30.


Genome-wide analysis of yeast stress survival and tolerance acquisition to analyze the central trade-off between growth rate and cellular robustness.

Zakrzewska A, van Eikenhorst G, Burggraaff JE, Vis DJ, Hoefsloot H, Delneri D, Oliver SG, Brul S, Smits GJ.

Mol Biol Cell. 2011 Nov;22(22):4435-46. doi: 10.1091/mbc.E10-08-0721. Epub 2011 Sep 30.


Dynamic regulation of mitochondrial respiratory chain efficiency in Saccharomyces cerevisiae.

Postmus J, Tuzun I, Bekker M, Müller WH, de Mattos MJ, Brul S, Smits GJ.

Microbiology. 2011 Dec;157(Pt 12):3500-11. doi: 10.1099/mic.0.050039-0. Epub 2011 Sep 29.


Intracellular pH is a tightly controlled signal in yeast.

Orij R, Brul S, Smits GJ.

Biochim Biophys Acta. 2011 Oct;1810(10):933-44. doi: 10.1016/j.bbagen.2011.03.011. Epub 2011 Mar 21. Review.


Subunits Rip1p and Cox9p of the respiratory chain contribute to diclofenac-induced mitochondrial dysfunction.

van Leeuwen JS, Orij R, Luttik MA, Smits GJ, Vermeulen NP, Vos JC.

Microbiology. 2011 Mar;157(Pt 3):685-94. doi: 10.1099/mic.0.044578-0. Epub 2010 Dec 9.


Phosphatidic acid is a pH biosensor that links membrane biogenesis to metabolism.

Young BP, Shin JJ, Orij R, Chao JT, Li SC, Guan XL, Khong A, Jan E, Wenk MR, Prinz WA, Smits GJ, Loewen CJ.

Science. 2010 Aug 27;329(5995):1085-8. doi: 10.1126/science.1191026.


Comparative analysis of transcriptome and fitness profiles reveals general and condition-specific cellular functions involved in adaptation to environmental change in Saccharomyces cerevisiae.

Zakrzewska A, Boorsma A, Beek AT, Hageman JA, Westerhuis JA, Hellingwerf KJ, Brul S, Klis FM, Smits GJ.

OMICS. 2010 Oct;14(5):603-14. doi: 10.1089/omi.2010.0049. Epub 2010 Aug 9.


Development of the pacemaker tissues of the heart.

Christoffels VM, Smits GJ, Kispert A, Moorman AF.

Circ Res. 2010 Feb 5;106(2):240-54. doi: 10.1161/CIRCRESAHA.109.205419. Review.


Measuring enzyme activities under standardized in vivo-like conditions for systems biology.

van Eunen K, Bouwman J, Daran-Lapujade P, Postmus J, Canelas AB, Mensonides FI, Orij R, Tuzun I, van den Brink J, Smits GJ, van Gulik WM, Brul S, Heijnen JJ, de Winde JH, de Mattos MJ, Kettner C, Nielsen J, Westerhoff HV, Bakker BM.

FEBS J. 2010 Feb;277(3):749-60. doi: 10.1111/j.1742-4658.2009.07524.x. Epub 2010 Jan 7.


In vivo measurement of cytosolic and mitochondrial pH using a pH-sensitive GFP derivative in Saccharomyces cerevisiae reveals a relation between intracellular pH and growth.

Orij R, Postmus J, Ter Beek A, Brul S, Smits GJ.

Microbiology. 2009 Jan;155(Pt 1):268-78. doi: 10.1099/mic.0.022038-0.


Quantitative analysis of the high temperature-induced glycolytic flux increase in Saccharomyces cerevisiae reveals dominant metabolic regulation.

Postmus J, Canelas AB, Bouwman J, Bakker BM, van Gulik W, de Mattos MJ, Brul S, Smits GJ.

J Biol Chem. 2008 Aug 29;283(35):23524-32. doi: 10.1074/jbc.M802908200. Epub 2008 Jun 18.


Transcriptome analysis of sorbic acid-stressed Bacillus subtilis reveals a nutrient limitation response and indicates plasma membrane remodeling.

Ter Beek A, Keijser BJ, Boorsma A, Zakrzewska A, Orij R, Smits GJ, Brul S.

J Bacteriol. 2008 Mar;190(5):1751-61. Epub 2007 Dec 21.

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